1.
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12)1999.
Artigo
em Chinês
| WPRIM
| ID: wpr-558675
RESUMO
AIM: To study the effect of decreasing blood pressure on mechanical and heat pain sensitivity in spontaneously hypertensive rats.METHODS: 15 SHRs were intramuscularly given reserpine(1(?g?kg~(-1)?d~(-1))) on day 4-11.Blood pressure,paw withdrawal mechanical threshold(PWMT) and paw withdrawal thermal latency(PWTL) were measured every day.RESULTS: After the therapy of reserpine in spontaneously hypertensive rats,blood pressure decreased by 50 mmHg,mechanical and heat pain threshold were both decreased(P