RESUMO
Chinese herbal prescription (CHP) is the main method and mean of clinical medication in traditional Chinese medicine (TCM). The CHP efficacy is the summary of multi-herb function under the guidance of TCM theories. With the development of modern science and technology, the scientific and organic interpretation of scientific connotation of CHP efficacy is a difficult problem in TCM. In this paper, the modern research ideas and methods of CHP efficacy, which greatly enriched the modern research content of CHP efficacy as well as promoted its research and development, were discussed and summarized.
RESUMO
The pharmacological characteristics of recipes are multi-components, multi-ways, multi-links, and multi-targets, on which the efficacy substances in recipes are worth of studying. To explore the essential substances of Chinese herbs in recipe is one of the key points for modernization of Chinese materia medica. The pharmacological effects and bioactivities inside the target tissue of lesion body are still not clear, even though there are some progress in herb serum pharmacology, recipe pharmacokinetics, and pharmacodynamics. The main effective components of recipe to pancreas in acute pancreatitis models by ig or enema were investigated by HPLC-MS method so as to establish a new hypothesis (tissue pharmacology of recipe): i.e. guided hy fundamental theory of traditional Chinese medicine to study the effect and the mechanism of recipe's essential substances on target tissues with pharmacological methods; to establish the experimental method for searching the foundation, the principle, and the direct substances of recipes which act on target tissues; to form more effective formula if possible, and to explore in a new researching field for the recipes of Chinese materia medica.