Assessment of the physical status of elderly patients with prostate cancer / 中华男科学杂志

Prostate cancer (PCa) is the primary malignancy threatening men's health in the United States and its incidence is increasing in China year by year. Many PCa cases are found in the advanced stage or in the old age, treated with unstandardized options, with negligence of comprehensive assessment of the patient's physical status, which may frequently add to the physical, psychological and economic burdens of the patient and even result in death. On the other hand, some excessively conservative therapeutic options may cause the loss of the best time of management or lead to deterioration of the disease. Therefore, sufficient importance should be attached to the comprehensive assessment of the physical status of the elderly PCa patient before treatment and the choice of the best therapeutic protocol.

Impact of the ASA Physical Status Score on Adjuvant Chemotherapy Eligibility and Survival of Upper Tract Urothelial Carcinoma Patients: a Multicenter Study

The aim of the present multi-institutional study was to assess the influence of the American Society of Anesthesiologists Physical Status (ASA-PS) classification on adjuvant chemotherapy eligibility and survival in a multi-institutional cohort of patients treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). We retrospectively reviewed data from 416 patients who underwent RNU for UTUC at four Korean institutions between 2001 and 2013. The ASA-PS classification was obtained from the anesthesia chart. Locally advanced UTUC was defined as ≥ pT3 and/or pN1 disease. The influence of ASA-PS score on survival was evaluated by Kaplan-Meier analyses and a multivariate Cox regression model. Patients with a higher ASA-PS class were less likely to be eligible for adjuvant chemotherapy in locally advanced UTUC (P = 0.016). Kaplan-Meier estimates showed that the high-risk ASA-PS group has a poorer overallsurvival (OS) and cancer-specific survival (CSS) compared to low risk ASA-PS groups in both the total and locally advanced UTUC cohorts. Based on multivariate Cox regression analysis, the high-risk ASA-PS category was an independent predictor for overall mortality (OM) (hazard ratio [HR], 1.919; 95% confidence interval [CI], 1.017–3.619; P = 0.044) and cancer-specific mortality (CSM) (HR, 2.120; 95% CI, 1.023–4.394; P = 0.043). In conclusion, high-risk ASA-PS score was independently associated with a lower survival rate in patients with UTUC after RNU. However, the influence of ASA-PS classification on survival was limited to locally advanced UTUC. The lower eligibility of patients in the high-risk ASA category for adjuvant chemotherapy may contribute to the lower survival rate in this group.

Human papillomavirus (HPV) genome status & cervical cancer outcome - A retrospective study.

Background & objectives: Persistent infections with high-risk (HR) human papillomaviruses such as HPV 16, 18, 31, 33 and 45 have been identified as the major aetiological factor for cervical cancer. The clinical outcome of the disease is often determined by viral factors such as viral load, physical status and oncogene expression. The aim of the present study was to evaluate the impact of such factors on clinical outcome in HPV16 positive, locally advanced cervical cancer cases. Methods: One hundred and thirty two pretreatment cervical tumour biopsies were selected from patients undergoing radiotherapy alone (n=63) or concomitant chemo-radiation (n=69). All the samples were positive for HPV 16. Quantitative real time-PCR was carried out to determine viral load and oncogene expression. Physical status of the virus was determined for all the samples by the ratio of E2copies/E7copies; while in 73 cases, the status was reanalyzed by more sensitive APOT (amplification of papillomavirus oncogene transcripts) assay. Univariate analysis of recurrence free survival was carried out using Kaplan-Meier method and for multivariate analysis the Cox proportional hazard model was used. Results: The median viral load was 19.4 (IQR, 1.9- 69.3), with viral integration observed in 86 per cent cases by combination of the two methodologies. Both univariate and multivariate analyses identified viral physical status as a good predictor of clinical outcome following radiation treatment, with episomal form being associated with increased recurrence free survival. Interpretation & conclusions: The present study results showed that viral physical status might act as an important prognostic factor in cervical cancer.

Is there any difference in American Society of Anesthesiologists physical status score between nonagenarian and septuagenarian patients?

BACKGROUND: As the life expectancy increases, extreme old age is not a contraindication to surgery. Limited information is available regarding preoperative evaluation for very old patients in Korea. We hypothesized that the American Society of Anesthesiologists physical status (ASA PS) score would differ between nonagenarian and septuagenarian patients in Korea. METHODS: The medical records of 100 nonagenarian (90s group) and septuagenarian (70s group) patients who had received elective surgery under general or regional anesthesia were reviewed to investigate their nutritional status, coexisting diseases, surgical procedure related cardiac risk, and ASA PS before surgery. RESULTS: The body mass index, hemoglobin, arterial oxygen partial pressure and albumin levels were significantly lower in the 90s group than in the 70s group. The age-adjusted Charlson Comorbidity Index was significantly higher in the 90s group than in the 70s group. The intermediate cardiac risk associated with surgical procedures was significantly higher in the 90s group than in the 70s group. There was no significant difference in the ASA PS class between the 90s group and the 70s group. CONCLUSIONS: The nonagenarian patients did not present a significant difference from the septuagenarian patients in ASA PS classification. However, the comorbidity index scores and cardiac risk related to surgical procedures were higher in the 90s group than in the 70s group. Thus, in the preoperative evaluation of very old patients, a category assessing their physiologic reserve should be added.

Correlation between Physical Status of Human Papilloma Virus and Cervical Carcinogenesis / 华中科技大学学报（医学）（英德文版）

The prevalence of human papilloma virus (HPV)-16 in patients with cervical cancer,the physical status of HPV-16 in patients with cervical lesions,and the role of HPV-16 integration in cervical carcinogenesis were investigated.HPV genotyping was performed by using PCR approach with the primer GP5+/GP6+ and type-specific primer on biopsy specimens taken operatively from 198 women.Multiple PCR was done to detect physical status of HPV-1 6 in a series of cervical liquid-based cytology samples and biopsy specimens obtained from different cervical lesions with HPV-16 infection,including 112 specimens with cervical cancer,151 specimens with CIN Ⅰ,246 specimens with CIN Ⅱ and 120 specimens with CINⅢ.The results showed that there were 112 cervical cancer samples (56.57％ of total cervical cancer patients) with HPV-16 infection.The frequency of HPV-16 pure integration was 65.18％ (73/112),56.57％ (47/120),23.58％ (58/246) and 7.95％ (12/151) in cervical cancer,CINⅢ,CIN Ⅱ and CIN Ⅰ patients respectively.In situ hybridization was performed on some paraffin-embedded sections of CIN Ⅱ,CINⅢ and cervical cancer to verify the physical status of HPV-16 infection.Significant difference was observed between cervical cancer and CIN Ⅰ,CIN Ⅱ,CINⅢ in the frequency of HPV-16 integration (P＜0.01).It is suggested that HPV-16 is the most prevalent type and is associated with cervical cancer.In the case of HPV-16 infection there are close associations between the severity of cervical lesions and the frequency of HPV-16 integration.The application of testing HPV genotyping and physical status based on detection ofHC- Ⅱ HPV DNA would be in favor of predicting the prognosis of cervical precancerosis and enhancing the screening accuracy of cervical cancer.

Valoración de cualidades físicas en mujeres adultas antes y después de un programa de ejercicio físico / Women´s physical status, before and after an exercise program

Introducción: Las cualidades físicas en la vida cotidiana son la expresión de numerosas funciones corporales, la pérdida progresiva de estas, constituye un problema de salud debido al deterioro del estado funcional de la persona modificando su calidad de vida, es necesario fomentar el buen estado de salud para poder llegar a edades más avanzadas de la vida con un mantenimiento y/o mejoramiento de las cualidades físicas para disfrutar plenamente la vida. Objetivo: Conocer los cambios en las cualidades físicas de mujeres adultas sedentarias evaluándolas comparativamente al inicio y término de un programa de entrenamiento físico. Metodología: Diseño del estudio prospectivo, longitudinal y comparativo, la población de estudio fue de mujeres de 45 a 60 años de edad, sedentarias, la muestra se constituyo a conveniencia con 47 mujeres que terminaron el programa de entrenamiento físico, las cualidades físicas se evaluaron antes y después de un programa de ejercicio físico. Para conocer el comportamiento de la muestra se obtuvieron medidas de tendencia central, dispersión y pruebas de correlación. Resultados: En la primera valoración las cualidades físicas que se encontraban con un mayor nivel de deficiencia fueron la fuerza (92%), flexoelasticidad de cadera (93%) y flexoelasticidad de mano (66%), al realizar la segunda valoración las cualidades físicas que alcanzando en promedio un incremento significativo estadísticamente fueron la fuerza con 1.2 Kg, la velocidad de reacción visual con 1.1 mseg, la flexoelasticidad de tronco con 3.6 cm y la flexoelasticidad de mano con 0.9 cm. Discusión: Coincidimos con Sánchez Pinilla en lo referente a que la capacidad para mejorar las cualidades físicas dependerá de la cantidad de trabajo y tipo de ejercicio físico especifico para cada una de ellas, lo cual pudo haber contribuido a una mejora más significativa de las cualidades físicas. Conclusiones: De acuerdo con los resultados el presente estudio es una herramienta que puede ser empleada para analizar los efectos del ejercicio físico sobre las cualidades físicas.

Introduction: Physical status is the expression of several body functions, and its progressive impairment represents a health problem; therefore, it is necessary to promote healthy habits in people so that they can enjoy a high quality of life for as long as possible. Objective: To address the physical status changes in sedentary women before and after their participation in an exercise program. Methodology: Prospective study, addressing the physical status of 47, 45-60 year-old, sedentary women before and after an exercise program. The SPSS v16 was used to obtain central tendency, dispersion, and correlation data. Results: In the first assessment, strength, hip flex-elasticity, and hand flex-elasticity were found to be the most impaired. In the second assessment, the physical capacities which showed statistically significant average increments were: strength (1.2 kg), visual reaction velocity (1.1 msec), trunk flex-elasticity (3.6 cm), and hand flex-elasticity (0.9 cm). Discussion: We agree with Sanchez Pinilla that the capacity to improve physical performance will depend on the quantity and type of exercise involved. Conclusion: Considering the results, this study can be a reference to help analyze the effects of exercise on the physical status.

The Effects of an Exercise Program on the Physical, Physiological and Emotional Status of the Aged

No abstract available.

A Study on Emotional Status, Physical Status, and Family Support of Parents with Cardiac Disease Children / 아동간호학회지

The object of this study is to provide the basic data for the caring of parents by understanding emotional status, physical status, and family support of parents with cardiac disease children. The subjects of this study were consisted of 105 parents of cardiac disease children admitted at 'G' hospital in Inchon, and 'S' hospital in Puchon. The data were collected from November 6 to December 21, 2000. Four instruments were used to collect the data : Spielberger's STIS, Cornell Medical Index(CMI), Yang's stress scale, and Moos's Family Environment Scale Form R, the latter 3 are modified by researcher. The collected data were tested using frequencies, percentiles, means, t-test, ANOVA, and Pearson correlation coefficient with SPSSWIN program. The results of this study were as follows: 1. There were statistically significant differences in degree of anxiety on age, number of children, and children's order of birth. 2. There was a statistically significant difference in degree of physical status on presence of the other patient in family. 3.There were not statistically significant differences in degree of stress and family support on demographic factors. 4.There were positive correlations between physical status and family support, and between anxiety and stress, but negative correlations between family support and stress, between anxiety and family support, between anxiety and physical status, and between stress and physical status.

A Study of Food Habits, Phusical Status and Related Factors of College Students in Chuncheon / 대한지역사회영양학회지

In order to investigate the relationship among physical status, eating habits and life style, this survey was carried out by questionnaire in 1996. College students(413 cases) who resided in Chuncheon answered. The results are as follows: 1) The means of height and weight were 173.9+/-5.0 cm, 64.5+/-8.3 kg in male students and 160.9+/-4.5 cm, 51.1+/-5.8 kg in female students. 2) Under 20 of BMI(Body Mass Index) were 23.0% of male students and 58.3% of female students. 6.7% of males and 3.0% of females were over 25 of BMI. 3) There was a significant relationship between the type of favorite snacks and gender. There was a significant difference of BMI according to the level of the frequency and the amount of drinking alcoholic beverages. 72.6% of subjects took exercise regularly. But the BMI of subjects taking regular exercise and watching the weight tended to be higher than that of subjects not doing so. 4) Most students(78.5%) skipped breakfast, which was higher in the self-boarding students in than any other. It was because of the lack of time that they skipped their meals. This study suggests that a comprehensive nutrition education program is needed for college students in self-boarding houses and dormitories to improve their eating habits about skipping meals, and especially for female students to prevent inappropriate weight control.