RESUMO
BACKGROUND: With the application of tissue engineering technology In the field of stomatology, It Is possible to construct a tissue-engineered dental pulp for the regeneration of dentin-pulp complex. Formation of new blood supply system through angiogenesis Is mandatory to dental pulp regeneration. Angiogenesis is defined as the formation of new blood vessels from preexisting capillaries, which has great significance in pulp regeneration and homeostasis. OBJECTIVE: To review the contribution of exosomes and angiogenic factors to angiogenesis in the dental pulp. METHODS: A search of PubMed and CNKI was performed for relevant literature published from 2017 through 2019. The search terms were "tissue engineering, pulp regeneration, regenerative endodontics, angiogenesis, neovascularization, angiogenic, signal molecules, exosomes, factors, role, mechanism" In English and Chinese, respectively. RESULTS AND CONCLUSION: Many studies have indicated an intimate relationship between angiogenesis and dental pulp regeneration. The contribution of exosomes and angiogenic factors to angiogenesis of the dental pulp has been previously discussed. Angiogenesis is an indispensable process during dental pulp regeneration. The survival of transplanted pulp tissue is closely linked to the process of angiogenesis at sites of application. However, further Investigations are warranted on the detailed regulatory mechanisms of exosomes and factors Involved In Initiation and progression of angiogenesis In pulp tissue.
RESUMO
Accumulative evidences have underpinned the nature candidates from Chinese medicine (CM), particularly CM served as blood activating and stasis resolving (BASR, Huoxue Huayu in Chinese) by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that (1) BASR-CM might emphasize on a balanced multi-cytokines network interaction; (2) BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; (3) BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.