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Angiogenesis is a process that new blood vessels generate on the basis of an original vascular plexus via sprouting or other forms during normal growth and development of an organism or under particular conditions such as wound repairing and ischemic hypoxia. In general, angiogenesis includes five stages: degradation of the vascular basement membrane, endothelial cell proliferation, vascular sprouting, lumen formation and vascular network turning stable and mature. Among ischemic heart diseases, acute myocardial infarction seriously threatens human health, its pathological characteristics include myocardial vascular stenosis and blockage,leading to myocardial infarction. Therefore,the promotion of angiogenesis has become one of the therapies for ischemic heart diseases. A variety of pro-angiogenic cytokines are involved in the process of angiogenesis, such as polypeptide growth factors and lipid mediators. In this paper we review the recent progress in research on the expression of pro-angiogenic factors in myocardium after ischemic myocardial infarction.
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Objective To evaluate the correlations of pro-angiogenic miRNAs with risk and severity in patients with coronary artery disease (CAD). Methods After angiographic documentation, 10 patients with CAD and 10 healthy controls (HCs) were enrolled for screening the differently expressed microRNAs (DEMs) (exploration stage). Blood samples of 142 patients with CAD and 140 age- and gender-matched HCs with the same eligibility were collected (validation stage). And the plasma levels of DEMs were measured by real-time qPCR. Results In the exploration stage, miR-19a, miR-92a, miR-126, miR-130a, miR-210, miR-296, and miR-378 expression levels were higher, but miR-221 expression was lower in patients with CAD than in HCs. In the validation stage, plasma expression levels of miR-126, miR-130a, miR-210, and miR-378 were decreased in patients with CAD. Multivariate logistic regression revealed that miR-19a, miR-126, miR-130a, miR-210, and miR-378 were independent protective factors for CAD. Receiver operating characteristic (ROC) analysis displayed that testing of a combination of miR-19a, miR-126, miR-130a, miR-210, and miR-378 was of good value in predicting the risk of CAD, with an AUC of 0. 768. Additionally, miR-126 and miR-210 were negatively associated with Gensini scores. Conclusion miR-126, miR-130a, miR-210, and miR-378 could serve as promising biomarkers for predicting the risk and severity of CAD.
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[Objective]To explore the mechanism of bioactive tanshinones in Salviae Miltiorrhiae regulating angiogenesis and lay the foundation for the prevention and treatment of cancer, atherosclerosis, ischemic heart disease and other angiogenesis-related diseases. [Method]Based on angiogenesis mechanisms, infer to recent 10 years of articles from home and abroad, analyze and summarize the angiogenesis regulatory mechanisms of various bioactive ingredients in Danshen on endothelial cells, in vitro tumour cells and in vivo xenograft tumor. [Result] Among various bioactive ingredients of Salvia, Salvianolic acid B, Tanshinone IIA, Cryptotanshinone, Dihydrotanshinone I can promote or inhibit angiogenesis. Furthermore, Salvianolic acid B and Tanshinone IIA are considered to be the most important bioactive ingredients in Danshen and exhibit a dual angiogenic regulating activity through regulating various approaches, such as pro-angiogenic factors, MMPs, HIF-1α, the PI3K/AKT/eNOS signal pathway and so on. [Conclusion]Various bioactive ingredients of Salvia can serve as a regulator of angiogenesis, and it may provide new ideas for the prevention of angiogenesis-related diseases.