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OBJECTIVE: To explore the diagnostic value of serum Aspergillus IgG antibody combined with BALF galactoman(GM) in the diagnosis of pulmonary aspergillosis and provide a new scheme for clinical diagnosis of aspergillus infection. METHODS: 97 patients suspected of pulmonary aspergillus infection were selected in our hospital during March 2016 and September 2017. Serum IgG and BALF GM were performed for all, ROC curve analysis was used to compare the diagnostic value. RESULTS: 58 cases diagnosed as pulmonary aspergillosis and 39 non-aspergillus infection patients were enrolled in this study as patient group and control group, respectively. Serum IgG antibody level in patient group is significant higher than control group(P<0.05), and also higher in chronic pulmonary aspergillosis(CPA) patients, compared with invasive pulmonary aspergillosis(IPA) patients. The sensitivity and specificity were 53.4%, 94.9% respectively if the cut-off value of serum IgG test was set as 140 IU/ml. When the cut-off value of BALF GM test was 0.5, the sensitivity and specificity were 75.9%, 76.9%. The ROC curve area of serum IgG antibody, BALF GM was 0.770, 0.813, respectively. When combined serum IgG antibody and BALF GM together, the area under the curve was 0.897. Conclution The combined serum IgG antibody and BALF GM tests improved the diagnostic value of pulmonary aspergillosis, it is recommended to clinical diagnosis.
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Objective To discusses the reason and effective prevention and control nursing measures in severe craniocerebral injured patients complicated with secondary pulmonary aspergillosis.Methods The reason of 21 severe craniocerebral injury patients infected by pulmonary aspergillosis were analyzed,and comprehensive nursing care was given to these patients,including strict disinfection and isolation,strengthening management of hospital environment,early close observation of disease,applying effective antifungal drugs in time,strengthening the medication nursing and nutrition support,standard antibiotic application,attention to the respiratory tract management,basic and college nursing.Results 13 cases were recovered,4 cases were better,4 cases died,the mortality rate was 19％.Conclusions Reasonable treatment and nursing care to the severe craniocerebral injury patients complicated with secondary pulmonary aspergillosis can effectively prevent and control the spread of pulmonary aspergillosis in the hospital,improve the cure rate,reduce the complications and the mortality rate,and ensure the safety of patients.