1.
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12): 315-322, 2023.
Artigo
em Chinês
| WPRIM
| ID: wpr-1014671
RESUMO
This article introduces the mechanism including antigen presentation, adjuvant, lymphatic system and the characteristics of vaccine, and then summarizes the key applications of core pharmacometrics approaches including QSP, PK/PD, dose response analysis, MBMA, in dose-response, preclinical and clinical translation, and correlation between biomarkers and efficacy of vaccines. It is expected that the successful application of model informed drug development can promote model informed vaccine development so that pharmacometrics makes its due contributions to the development of safer, more effective and more controllable vaccine products.