RESUMO
Through efforts of several generations over the past half century,great advances have been achieved in the develop?ment of radiation countermeasures for the acute radiation sickness(ARS). Convergent studies have disclosed numerous radioprotec?tants with significant radioprotective efficacy which include granulocyte colony stimulating factor(G-CSF),granulocyte macrophage colony stimulating factor(GM-CSF),thrombopoietin(TPO),interleukin-12,derivatives of the bacterial flagellin,androst-5-ene-3β, 17β-diol(AED),beclomethasone 17,21-dipropionate(BDP),vitamin E(and its)derivatives,and genistein. particularly,the two growth factors G-CSF and TPO show greater radioprotective effects. In this paper,we summarize the radioprotective effects of com?pounds or biological agents on severe ARS(SARS),which have been evaluated in large animal models or assembled into a nuclear accident emergency treatment medicine box,and review their research advances in recent years.
RESUMO
Through efforts of several generations over the past half century, great advances have been achieved in the development of radiation countermeasures for the acute radiation sickness (ARS). Convergent studies have disclosed numerous radioprotectants with significant radioprotective efficacy which include granulocyte colony stimulating factor (G-CSF), granulocyte macrophage colony stimulating factor (GM-CSF), thrombopoietin (TPO), interleukin-12, derivatives of the bacterial flagellin, androst-5-ene-3β, 17β-diol (AED), beclomethasone 17, 21-dipropionate (BDP), vitamin E (and its)derivatives, and genistein. particularly, the two growth factors G-CSF and TPO show greater radioprotective effects. In this paper, we summarize the radioprotective effects of compounds or biological agents on severe ARS (SARS), which have been evaluated in large animal models or assembled into a nuclear accident emergency treatment medicine box, and review their research advances in recent years.
RESUMO
The application of nuclear energy and nuclear technology has brought great convenience to human beings, but also greatly increases the potential risk of people exposed to radiation injury. Radioprotectants could reduce morbidity or mortality produced by ionizing irradiation. Substantial efforts to develop medically effective radioprotectant were initiated for a long time. The research of radioprotectant with good protection effect and low toxicity has become the focus, and some candidate drugs have been found. The biological agents, as the preventive and therapeutic medical measures for the acute radiation syndrome, have exhibited a good prospect. This review is an attempt to provide vital information about the current status of some representative biological radioprotectants and their future perspective.
RESUMO
The application of nuclear energy and nuclear technology has brought great convenience to human beings, but also greatly increases the potential risk of people exposed to radiation injury. Radioprotectants could reduce morbidity or mortality produced by ionizing irradiation. Substantial efforts to develop medically effective radioprotectant were initiated for a long time. The research of radioprotectant with good protection effect and low toxicity has become the focus, and some candidate drugs have been found. The biological agents, as the preventive and therapeutic medical measures for the acute radiation syndrome, have exhibited a good prospect. This review is an attempt to provide vital information about the current status of some representative biological radioprotectants and their future perspective.