Continuous spinal anesthesia for renal homotransplantation / 国际外科学杂志

Objective To discuss the feasibility and safety of continuous spinal anesthesia (CSA) in renal transplantation through comparing the effects of combined spinal and epidural anesthesia (CSEA) and CSA renal transplantation. Methods Sixty patients undertaking renal transplantation were divided into two groups randomly. Group A, 30 patients, undertaking operation with CSEA; Group B, 30 patients, undertaking operation with CSA. The patients in group A were injected 2 mL 0.75% ropivacaine, then epidural catheter was inserted, 0. 75% ropivacaine 10 mL was administered when needed. The patients in group B were injected 2 mL 0.75% ropivacaine into spinal through Spinocath catheter, and 0.75% ropivacaine 1ml was administered through Spinocath catheter when needed. We observed the effects of the two anesthesia methods and the changes of the patients' vital signs. Results The patients in group A and B all completed the operation smoothly; there were no significant differences in the circulatory function before and during operation; there were no complications related to anesthesia in all the patients; group B was superior to group A in the aspects of the control and maintaining of anesthesia. Conclusion Continuous spinal anesthesia applied to renal transplantation is safe and feasible.

Canine Renal Homotransplantation: II. Pathologic Study in Imuran-treated Homografts / 대한비뇨기과학회지

As follow-up of Song's experiments reported previously, this study was undertaken to observe pathologic changes in Imuran-treated renal homografts in dogs. Mongrel dogs weighing 15 to 20 kilograms were used in all experiments. Renal transplants were exchanged between animals. Imuran was administered twice a day per oral with daily doses of 3mg. per kilogram of body weight, and the first dose was given 24 hours before renal transplantation. Transplanted kidney were removed on the postoperative 1st, 3rd, 7th, 14th. 20th, and 30th day, and the were examined microscopically with Hematoxylin-Eosin staining. As comparing with the results of Song's experiments which were untreated homotransplants, the appearance of characteristic microscopic changes of rejection (progressive destructive changes of vessels with infiltration of lymphocytes, polymorphonuclear leukocytes and plasma cell) was temporarily delayed and modified by Imuran administration, but ischemic changes developed imminently in later days.