Chemical Components of Traditional Chinese Medicine in Treating Alzheimer's Disease and Its Mechanism： A Review / 中国实验方剂学杂志

Alzheimer's disease （AD） is one of the most common diseases in the elderly population. Its etiology involves multiple pathogenic factors and pathological links such as abnormal deposition of β amyloid protein （Aβ）， hyperphosphorylation of Tau protein， abnormalities of the cholinergic system， oxidative stress， and inflammatory response. However， its specific pathogenesis has not been clarified， and no specific therapeutic drugs have been found. In recent years， more and more studies have paid attention to the potential of chemical components of traditional Chinese medicine （TCM） in the treatment of AD. However， the diversity and complexity of the chemical components of TCM may have a positive impact on multiple pathological links of AD. Researchers have isolated many active components from TCMs， and the effects of treating AD have been confirmed by modern pharmacological studies. Through literature analysis， this article found that the main chemical components of TCM with anti-AD effects were saponins （31%）， flavonoids （24%）， polysaccharides （20%）， lactones （8%）， alkaloids （7%）， phenols （3%）， and other compounds （7%）. Among them， ginsenoside， notoginsenoside， epimedium flavones， puerarin， baicalein， schisandra polysaccharide， angelica polysaccharide， ganoderma lucidum polysaccharide， pachyman， huperzine A， berberine， andrographolide， curcumin， emodin， and gastrodin have been extensively studied in terms of their anti-AD effects， and their mechanisms of pharmacological action have been involved in many aspects of AD pathogenesis. This article reviews the anti-AD activities and possible mechanisms of chemical components of TCM， so as to provide a reference for the development of new drugs for the prevention and treatment of AD.

Review of clinical research in acupuncture and moxibustion from 2010 to 2020 and future prospects / 中国针灸

The progress of Chinese clinical research on acupuncture and moxibustion in recent 10 years was reviewed and analyzed, and corresponding suggestions were put forward for the current problems. In the past 10 years, Chinese clinical research on acupuncture and moxibustion has made considerable progress, mainly in the following areas: a series of internationally recognized clinical research evidences have been published, a preliminary acupuncture clinical evaluation system has formed, sham/placebo acupuncture control is widely used internationally, acupuncture clinical research norms and standards have been initially established. However, the following issues still need to be paid attention to in follow-up research: focus on the overall layout and refinement of clinical research, further improvement of clinical evaluation system, developing relevant norms for sham/placebo acupuncture setting and reporting, strengthening data sharing and platform integration, building a smooth basic and two-way transformation clinical pathway, etc.

A Research Review of the Red Doctors’ Spirit / 中国医学伦理学

At present, the research on the red doctors’ spirit mainly focuses on the historical research, the connotation research, the significance research and the inheritance path research of the red doctors’ spirit. From the current research status, it can be found that the core connotation of the red doctors’ spirit needs to be further refined, the research depth needs to be further deepened, the research breadth needs to be further expanded, and the attention to the real society needs to be further enhanced.

Distribución geográfica y brecha de género en la revisión por pares de una revista científica biomédica en Latinoamérica / Geographic distribution and gender gap in the peer review of a Latin American biomedical scientific journal

La revisión por pares es un proceso importante al permitir tomar decisiones previas a la publicación de un artículo. Sin embargo, existe escasa información en revistas científicas de Latinoamérica sobre los profesionales que participan en estos procesos. Este trabajo se propuso determinar la distribución geográfica y de género en la revisión por pares realizada en la Revista Peruana de Medicina Experimental y Salud Pública. Se analizaron las listas de agradecimiento de quienes participaron en la revisión por pares de esta revista desde el año 2010 hasta el 2017. El país de procedencia se identificó a partir de la afiliación institucional, mencionada inicialmente por los revisores, y para la identificación del género se utilizaron los nombres. En caso de existir duda con el género se realizó una búsqueda de imágenes y de perfiles académicos públicos disponibles en Internet. Se encontraron 1 628 menciones de agradecimientos a profesionales que participaron en la revisión por pares; el 60,4 por ciento (n = 983) fueron procedentes del extranjero, principalmente de España, México, Chile, Colombia y Argentina. El 71,1 por ciento (n = 1158) fueron revisores hombres y el 28,9 por ciento (n = 470) revisoras. según la procedencia de las revisoras, el 35,0 por ciento (n = 344) fueron del extranjero y el 19,6 por ciento (n = 126) de Perú; y en los revisores hombres el 65,0 por ciento fueron del extranjero y el 80,6 por ciento de Perú. La revisión por pares en una revista científica biomédica en Perú fue realizada principalmente por profesionales de otros países de habla hispana. Existe una brecha de género que es mayor para la participación de revisoras de Perú(AU)

Peer review is an important process that makes it possible to take decisions before the publication of an article. However, little information is available in Latin American scientific journals about the professionals involved in this process. The purpose of the study was to determine the geographic and gender distribution of peer review in the Peruvian Journal of Experimental Medicine and Public Health. Data about peer reviewers were obtained from the acknowledgements sections of journal issues published from 2010 to 2017. The country of origin was identified from the institutional affiliation reported by peer reviewers, and gender was derived from their proper names. In the event of doubt about a reviewer's gender, a search was conducted for images and public academic profiles available on the Internet. A total 1 628 acknowledgement mentions were found, 60.4percent (n = 983) of which referred to overseas reviewers, mainly from Spain, Mexico, Chile, Colombia and Argentina. 71.1percent (n = 1 158) of the reviewers were male and 28.9percent (n = 470) were female. 35.0percent (n = 344) of the female reviewers were foreign and 19.6percent (n = 126) were from Peru, whereas 65.0percent of the male reviewers were foreign and 80.6percent were from Peru. Peer review in a Peruvian biomedical scientific journal was mainly conducted by professionals from other Spanish-speaking countries. A gender gap was observed which is wider for participation of Peruvian female reviewers(AU)

Bibliometric Analysis of Pharmacoeconomic Evaluation Research Literatures in China Based on Chinese Journal Full-text Database / 中国药房

OBJECTIVE： To analyze the development situation of pharmacoeconomic evaluation research in China， and to provide reference for pharmacoeconomics discipline construction. METHODS： China journal full-text database was searched by computer. The searching time was from database establish to Dec. 2018. After collecting the academic papers with the theme of “pharmacoeconomic evaluation”， statistical analysis was made on publication year， source journals， institutions， authors， cooperation publication， citation information and keywords of papers by bibliometric method. RESULTS & CONCLUSIONS： A total of 1 197 literatures were included. The earliest literature was published in 1993， and the largest number （104 pieces） was published in 2015. The literatures came from 289 journals. Among which， China Pharmacy published the largest number of literatures （123 pieces）； the first author came from 619 institutions， which mainly were China Pharmaceutical University （124 pieces）； a total of 2 352 authors were involved， and 923 literatures were completed by two or more authors， with co-authorship rate of 77.1％. The total number times of authors was 3 480， and the degree of cooperation was 2.91. As of April 19， 2019， 975 literatures had been cited. The cited rate was 81.4％， the average citation frequency was 5.83 times， and the H-index was 29. There were a total of 1 922 keywords in the literatures， the top three keywords in the list of frequency were pharmacoeconomics （805 times）， cost-effectiveness analysis （209 times）， and pharmacoeconomic evaluation （98 times）. It could be seen that the research literatures on pharmacoeconomic evaluation in China were published earlier and widely distributed； the research content of the literatures was comprehensive， and some literatures had high influence. But the total number of literatures is still small and is distributed unevenly， and the number of core authors is insufficient， and related research needs to be further developed.

Research progress of TRAIL network against tumor under the guidance of systems biology / 基础医学与临床

Tumor is a system-biology illness.Treatment of this intractable disease by any single medicine has not been realistic.In this review, we analyze the anti-tumor network of Tumor Necrosis Factor-related Apoptosis-indu-cing Ligand ( TRAIL ) by a system-biology technology and try to providecin individualized treatment strategy for TRAIL based therapy .

Research Progress of Acupuncture and Moxibustion on Spinal Cord Injury (review) / 中国康复理论与实践

@#Spinal cord injury is a kind of central nervous system diseases with high morbidity. Acupuncture and moxibustion has unique advantages in treating spinal cord injury and its complications including neurogenic bladder, neuropathic pain, intestinal disorders, and muscle spasms. This article reviewed the researches of acupuncture and moxibustion treatment on spinal cord injury. It is presented to provide reference for clinical research.

Literature review of multiple-site physician practice:Based on content analysis / 中国卫生政策研究

Objectives:This study aims to summarize the research progress of multiple-site physician practice to determine further research directions. Methods:Literature on Chinese multiple-site physician practice between 1949 and 2013 was obtained from CNKI, Wan fang database and CQVIP database, the annual volume distribution of se-lected documents was been described and the topics and content of literature cited at least once were summarized through literature content analysis. Results:The volume of literature increased rapidly from 2009, guided by related government policies. Content analysis is insufficient in the research areas of supporting policies, international experi-ences, relevant laws and empirical studies. Suggestions: Further research should focus on multiple-site physician practice policies themselves and supporting policy analysis, international comparisons of multiple-site physician prac-tice systems, studies into relevant laws and regulations and empirical studies based on quantitative methods.

Review of Research on Prevention and Regulative Factors of Myocardial Fibrosis / 浙江中医药大学学报

Under large amount of experiments and clinical studies,it summarizes the understanding of regulative factors of myocardial fibrosis from modern medicine,also reviews the research on the prevention of myocardial fibrosis by modern medicine and TCM. The development of myocardial fibrosis is a complex course functioned with many factors,and it is an effective method to prevent it with combination of TCM and western medicine.

Treatment of Poststroke Aphasia with Chinese and Western Medicine (review) / 中国康复理论与实践

@#Since the symptoms and mechanism of poststroke aphasia are various and complicated, there are a great deal of problems which are difficult to resolve yet. At the aspect of aphasia research, Chinese and Western medicine have different emphases, Chinese medicine emphasizes particularly on therapy, Western medicine emphasizes on discussing mechanism of aphasia, all kinds of sorts and evaluation of aphasia and pertinence rehabilitation, and so on; modern research methods include neurolinguistics, neuropsychology, cognitive science, neurorehabilitation, neuroelectrophysiology, neuroimage and so on, all these means of aphasia research often involve in cross multi-subject, furthermore becoming powerful implement of recognizing brain mechanism.

An Analysis of Nursing Research Related to Quality of Life Reported in Korea from 1987 to 1996 / 성인간호학회지

This study was done to analyze research trends and to suggest future directions for nursing research on the quality of life (QL) in Korea. The purposes of this study were to describe systematically 10 years of QL nursing, and to identify patterns of tools and significant variables on studies of QL. This article reviewed 71 nursing researches on QL between 1987 and 1996, by examining them according to the period of publication, research for a degree or not, research design, type of subjects, data collection methods, measurement instruments and range of reliabilities, type of nursing intervention, and association of QL and related variables. The findings of the analysis can be summarized as follows: 1. The number of studies related to QL increased from 1987 to 1994. But they have decreased since 1995. 48 of them(67.6%) identified surveys and correlational studies. 2. In all the titles of the studies, there were 7 types of concepts, including QL, quality satisfaction, life satisfaction, and well-being. Among them, QL was the most often used. 3. The subjects of 21 studies were healthy people. In 49 studies, patients had various illnesses. The majority of the patients were hemodialysis patients and cancer patients. Questionnaires were used for data collection in 58 studies. 56 studies were done for the thesis of a degree, while those in the remaining studies were not for degrees. 4. The research designs were various, except in the thesis for a doctorate. There were many more experimental studies(57.1%) done in the thesis for a doctorate. 5. The types of intervention were categorized as exercise(6), supportive care(3), reminiscence (2), relaxation(1), music(1), and hospice care(1). 6. As measurement tools, 14 types of tools relating to QL were used. 11 of them were composed of multiple dimensions. Among them, the QL Scale by You-Ja Ro(1988) was the most widely used in the studies. In the following, the Life Satisfaction Index by Jin Yun(1982), the Quality of life Scale of National Conference of Cancer nursing (1983), and the Life Satisfaction Index by Wood, Wylie and Sheafor(1969) were used. The reliabilities of the QL Scale were reported in 63 studies, and the Cronbach's alpha coefficients were over 0.7 in 60 cases. The quality of life scales included five dimensions; such as physical, psychological, social, economical, and spiritual dimensions. 7. There were two categories of factors influencing the quality of life: First, factors that cannot be changed by nursing intervention were; age, educational level, gender, marital status, income, employment status, occupation, number of family members, religion, and illness history. Second, factors that can be changed by nursing intervention were; physical activity, health status, the presence of complications, support, self-esteem, stress, self-efficacy, activities of daily life, physical strength, satifaction with life, and anxiety. Types of nursing intervention used to improve quality of life were; therapies in relaxation, exericse, reminiscence, and family support, social support, and hospice care. On the basis of the above findings, the following recommendations were made: 1. Further studies on the quality of life instruments of analysis are needed to provide an understanding of dimensions of life in detail. 2. A Meta-analysis needs to be conducted to identify intervention effects on the quality of life. 3. A tool development study is needed to measure the quality of life appropriately in different illnesses 4. More replicated analysis studies of QL are needed to prove the effect of variables on the QL.

An Integrative Review of Oncology Nursing Research: 1980-1998 / 간호학회지

The purposes of this study were to describe systematically 18 years of oncology nursing research in Korea and suggest it's direction in future. 149 nursing studies published from 1980 to 1998 were selected for the present study. There were examined the source and the design of study, type of subjects, measurement variables, the intervention outcome of experimental research, and theme of qualitative research. The results were as follows : 1. 121 of 149 studies were composed of master thesis and dissertation of graduate school. There were 55 correlations, 30 descriptions, 19 comparisons, 19 qualitative studies and 2 Q-methods as the type of research design. 2. Cancer patients without describing specified diagnose as subjects' characteristic were 44 of total studies. The others had various diagnoses such as gastric cancer, uterine cancer, breast cancer, leukemia, Iymphoma, colorectal cancer, and lung cancer. According to treatment type. patients receiving chemotherapy were the highest number distribution as 53 of all researches. 3. Most measurement instruments used for research were translated it into Korean that developed by foreigners, such as Zung's depression. Spielberg's anxiety, and Wallston's locus of control. 4. Quality of life was shown the most frequently among correlational researches. the next one was depression the third was hope, and so on. 5. There was the most frequent comparison between cancer and non-cancer patients in comparative researches. It was surveyed those variables as diet habits, risk factors, stressful life events, anxiety and depression and self-care capacity between two groups. 6. The subjects were mostly chemotherapy Patients as 15 of 24 experimental studies. Oral care and education were respectively the highest experimental interventions. 7. Qualitative researches about cancer were reported since 1991. Their themes were illness experience, adaptation process, dying experience, family experience, hope. caring, experience of health behavior, meaning of chemotherapy and experience of cancer survivor. Phenomenologic methodology was designed above 50% of qualitative researches. According to the above findings, cancer research had increased since 1990 and done mostly by descriptive design but a few experimental studies. As recommendations for the future, It is necessary to study the comparison of oncology nursing research internationally. the replication to establish the effect of nursing intervention and the family care of cancer patient.