Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 7 de 7
Filtrar
Adicionar filtros








Intervalo de ano
1.
International Eye Science ; (12): 270-276, 2024.
Artigo em Chinês | WPRIM | ID: wpr-1005394

RESUMO

AIM:To investigate the changes of retinal microcirculation after phacoemulsification and the influencing factors of visual acuity.METHODS: Retrospective analysis. A total of 264 cataract patients(264 eyes)who underwent phacoemulsification in our hospital from January 2022 to December 2022 were selected as the study objects. Patients were divided into < 0.3 group(66 eyes)and ≥0.3 group(198 eyes)according to the recovery of best corrected visual acuity(BCVA)at 3 mo after surgery. The changes of retinal microcirculation indexes were compared before and after treatment. Logistic regression and LASSO regression models were used to screen the influencing factors of postoperative BCVA. A nomogram prediction model of postoperative BCVA was constructed and verified. A restricted cubic spline Logistic regression model was established to analyze the dose-response relationship between end-diastolic velocity(EDV), peak systolic velocity(PSV)and the risk of BCVA recovery.RESULTS: At 3 mo postoperatively, EDV and PSV were significantly improved compared with those before treatment, and resistance index(RI)levels were significantly lower than those before treatment(all P<0.05). Preoperative EDV, PSV, aqueous humor cell grade, fundus lesion grade, advanced age and Emery grade were influencing factors for poor BCVA recovery after phacoemulsification in cataract patients(P<0.05). The AUC before and after validation of the nomogram model by Bootstrap method were 0.869(95%CI: 0.815-0.903)and 0.866(95%CI: 0.802-0.895), respectively. The sensitivity was 88.36% and 88.27%, and the specificity was 91.82% and 91.78%, respectively. Restricted cubic spline model analysis showed no nonlinear dose-response relationship between EDV and PSV levels and the risk of poor BCVA recovery in either male or female(P>0.05).CONCLUSION: After phacoemulsification, retinal microcirculation in cataract patients improved significantly. EDV, PSV, aqueous humor cell grade, fundus lesion grade, advanced age and Emery grade are all factors influencing poor BCVA recovery after cataract surgery.

2.
Arq. bras. oftalmol ; 85(4): 382-388, July-Aug. 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1383825

RESUMO

ABSTRACT Purpose: In this study, we aimed to show whether a difference exists between retinal and choroidal microcirculation findings between patients with familial Mediterranean fever and healthy controls. Methods: Thirty-two patients with familial Mediterranean fever and 30 healthy controls were included in the study. All the patients underwent a complete ophthalmologic examination, including best-corrected visual acuity and intraocular pressure measurement. The AngioVue optical coherence tomography angiography device (Optovue, Fremont, CA) with split-spectrum amplitude-decorrelation angiography was used to evaluate and examine the retinal microvascular structure. Three-dimensional en face Optical coherence tomography angiography images were obtained by examining the macula using the 3 x 3 mm scanning protocol in the Angio Retina mode and the optic nerve using the 3 x 3 mm scanning protocol in the Angio Disk mode. All the patients' right eyes were examined. Results: A total of 62 subjects were included in the study, of whom 32 (53.3%) were female and 30 (46.7%) were male. No statistically significant difference was found between the two groups in terms of optic nerve head or radial peripapillary capillary vessel density. On examination, the superficial capillary plexuses were statistically similar between the two groups, but the deep capillary plexus vessel density in the parafovea, superior hemi, temporal, and superior areas were significantly lower in the patients with familial Mediterranean fever. Conclusions: We found that the capillary plexus vessel density was significantly lower in the parafovea, superior hemi, temporal, and superior regions in the patients with familial Mediterranean fever than in the control group. Therefore, OCTA, a noninvasive study, may be useful for understanding the systemic effects of familial Mediterranean fever.


RESUMO Objetivos: Este estudo teve como objetivo mostrar se há diferença entre os achados da microcirculação retiniana e coroidal entre pacientes com febre mediterrânica familiar e um grupo controle saudável. Métodos: Trinta e dois pacientes com febre mediterrânica familiar e 30 controles saudáveis foram incluídos neste estudo. Todos os pacientes foram submetidos a um exame oftalmológico completo, incluindo a acuidade visual melhor corrigida e medida da pressão intraocular. O aparelho AngioVue Optical coherence tomography angiography (Optovue, Fremont, CA) com angiografia de correlação de amplitude de espectro dividido foi utilizado para avaliar e examinar a estrutura microvascular da retina. As angiotomografias de coerência ópticas en face tridimensionais foram obtidas examinando o protocolo de varredura macular 3 x 3 mm (modo angio retina) e o nervo óptico com o protocolo de varredura 3 x 3 mm (modo angio-disco). Todos os olhos direitos dos pacientes foram examinados. Resultados: Foram incluídos neste estudo, 62 sujeitos, dos quais 32 (53,3%) eram do sexo feminino e 30 (46,7%) do sexo masculino. Não houve diferença estatisticamente significativa entre os dois grupos quanto à densidade dos vasos da cabeça do nervo óptico ou da densidade dos vasos capilares peripapilares radiais. Durante o exame, os plexos capilares superficiais foram estatisticamente semelhantes entre esses dois grupos, mas a densidade profunda dos vasos do plexo capilar nas areas parafovea, hemi superior, temporal e superior foram significativamente menores nos pacientes com febre mediterrânica familiar. Conclusões: Verificamos que a densidade dos vasos do plexo capilar foi significativamente menor nas regiões parafovea, hemi superior, temporal e superior em pacientes com febre mediterrânica familiar em comparação com o grupo controle. Portanto, pode ser útil usar a angiotomografia de coerência óptica, por tratar-se de um estudo não invasivo, para melhor compreensão dos efeitos sistêmicos da febre mediterrânica familiar.

3.
International Eye Science ; (12): 1898-1901, 2020.
Artigo em Chinês | WPRIM | ID: wpr-829231

RESUMO

@#Various eye diseases, especially retinal disease, can change the retinal microvascular. In addition, the disease such as cardiovascular disease that involves systemic vascular change also exist the change of retinal microcirculation. Therefore, the change of retinal microvascular system is important diseases index which not only an auxiliary diagnostic index for ocular diseases, but also an important index for the evaluation of systemic diseases. This paper briefly reviews the detection methods of retinal microcirculation examination and the clinical application of these methods.

4.
International Eye Science ; (12): 27-31, 2020.
Artigo em Chinês | WPRIM | ID: wpr-777789

RESUMO

@#AIM: To observe changes in the flash electroretinogram(ERG)and retinal microcirculation in mice suspended by their tails, an animal model that simulates cephalad movement of bodily fluids under conditions of microgravity.<p>METHODS: Thirty-six adult male C57BL/6J mice(36 eyes)were randomly divided into three experimental groups and three control groups. Mice in the experimental groups were tail-suspended for 15d(Group one), tail-suspended for 30d(Group two), or tail-suspended followed by returning to normal position for 30d(Group three). Three control groups were similarly fixed with a harness but kept in the normal position for corresponding periods of 15, 30, and 60d. The mice were immediately examined using scotopic ERG(including oscillatory potentials \〖OPs\〗)and fundus fluorescein angiography(FFA)<i>in vivo</i>, and subsequently sacrificed to analyze the retinal histology(methods including immunohistochemistry and TUNEL staining)<i>in vitro</i>. Independent sample <i>t</i>-test was used for data comparison between the same time-point groups.<p>RESULTS: Following 15-days' tail-suspension, scotopic ERG showed a decline in OPs, but not in the b-wave; the second OP(O2)showed an amplitude of 197±33μV, which was about 60% of the control level(<i>t</i>=-5.938, <i>P</i><0.001). Following 30-days' tail-suspension, ERG recovered, with O2 showing an average value of 264±39μV; when compared to the corresponding control group(308±41μV), no significant difference was observed(<i>t</i>=-1.887, <i>P</i>>0.05). Morphologically, only the 15-days' tail-suspended mice showed FFA with microvascular dilation and tortuosity. Rhodopsin and cone-opsin were almost normal and no apoptotic-positive signals were detected in the retinas of the three tail-suspended groups.<p>CONCLUSION: Simulating cephalad shifting of bodily fluids as under microgravity, using short-term tail-suspension can affect rodent ERG and retinal microcirculation; however, the change is reversible with no obvious permanent injury observed in the retinas.

5.
Progress in Modern Biomedicine ; (24): 5309-5311,5353, 2017.
Artigo em Chinês | WPRIM | ID: wpr-615018

RESUMO

Objective:To investigate the effects of xuesaitong on the retinal microcirculation of patients with diabetic mtinopathy (DR).Methods:Ninety-five patients with DR admitted in our hospital were randomly divided into the control group and the observation group.Forty-eight patients in the control group were treated with conventional hypoglycemic agent,and those in the observation group were treated with xuesaitong.The retinal microcirculation indexes including EDV,PSV,RI,Vmax,Vmin,MV,hemorheology indexes including NBL,NBH,DE,Hct,AE,ESR,and clinical efficacy in both groups were observed and compared.Results:After treatment,the clinical efficacy of observation group was 87.8%,which was much higher than that of the control group (61.4%,P<0.05).The EDV,Vmax,and Vmin of control group were significantly improved than those before treatment (P<0.05),and EDV and PSV were much higher than those of control group,the RI,Vmax,Vmin,and MV were much lower (P<0.05).Additionally,the NBL and NBH in control group were much lower compared with those before treatment,while NBL,NBH,DE,Hct,AE,and ESR in control group were improved than those in control group,which were much improved that those of control group (P<0.05).Conclusion:Xuesaitong combined with conventional hypoglycemic therapy was effective in treating patients with diabetic retinopathy,which could significantly improved the retinal microcirculation and hemorheology.

6.
Journal of the Korean Ophthalmological Society ; : 338-343, 2003.
Artigo em Coreano | WPRIM | ID: wpr-70929

RESUMO

PURPOSE: Diabetic retinopathy (DR) has influence on peripheral retina, and progression of DR is thought to make prolongation of peripheral retinal circulation. However, there has been no study on circulation of peripheral retina. This study is to make a comparision of peripheral retinal microcirculation between control, non-proliferative diabetic retin-opathy (NPDR), and pre-and post-panretinal photocoagulation (PRP) of proliferative diabetic retinopathy (PDR). METHODS: The authors performed the study on 19 control eyes and 68 DR eyes (NPDR 31, PDR 37) and PDR group was subdivided into before and after PRP. The authors measured arm to retinal circulation time (ART), arteriovenous passage time (AVP), venous filling time (VFT) by scanning laser ophthalmoscope in upper temporal retinal vessel in order to evaluate peripheral retinal microcirculation. RESULTS: VFT was 9.4+/-0.3 sec in pre-PRP of PDR, 7.5+/-0.6 sec (p<0.05) in post-PRP of PDR and 6.4+/-2.2 sec in control, 8.17+/-1.90 sec (p<0.05) in NPDR. However, there is no significant difference in ART, AVP. CONCLUSIONS: Patients with NPDR showed prolongation of VFT compared to normal indivisuals. There was shortening of VFT in post-PRP of PDR similar to NPDR. Peripheral retinal circulation time after PRP can be utilized as an indicator of PRP effect.


Assuntos
Humanos , Braço , Retinopatia Diabética , Fotocoagulação , Microcirculação , Oftalmoscópios , Retina , Vasos Retinianos , Retinaldeído
7.
Journal of the Korean Ophthalmological Society ; : 2103-2113, 1998.
Artigo em Coreano | WPRIM | ID: wpr-123271

RESUMO

The purpose of this study is to evaluate the effects of 2% dorzolamide(Trusopt(R)) on the ocular blood flow and retinal microcirculation. To creat an experimental glaucoma model in rabbits and to study the effects of elevated intraocular pressure(IOP), ocular blood flow, retinal effects of elevated intraocular pressure(IOp), ocular blood flow, retinal microcirculation on rabbits eyes, we treated trabecular meshwork of 6 adult pigmented rabbits with Q-switched Nd;YAG laser. And then we investigated the IOP lowering effect, ocular blood flow, and the microcirculation on retina of 2% dorzolamide(Trusopt(R)) in experimental glaucoma model. The IOP, ocular blood flow and the microcirculation were measured with applanation pneumotonography(Alcon, Texas), pneumotonometric probe linked to Langham ocular blood foow system(OBF, Blue mountain) and Heidelberg Retina Flowmeter(HRF). During sustained IOP elevation, 2% dorzolamide(Trusopt(R)) was instilled in one eye and normal saline in the fellow eye. The IOP and ocular blood flow were measured 1, 2, 4 and 8 hours after instillation. The retinal microcirculation was measured 2 and 8 hours after instillation. The retinal microcirculation was measured 2 and 8 hours after instillation at 200micrometer apart from the superior optic disc margin. There were statistically significant reductions in IOP in both 2% dorzolamide(Trusopt(R)) and normal saline-treated eyes(P0/1). From the above results, we concluded that 2% dorzolamide(Trusopt(R)) reduced the IOP but did not alter ocular blood flow and peripapillary retinal microcirculation.


Assuntos
Adulto , Humanos , Coelhos , Glaucoma , Pressão Intraocular , Microcirculação , Retina , Retinaldeído , Malha Trabecular
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA