RESUMO
Objective To investigate the correlation between plasma paliperidone concentration and serum prolactin level .Meth‐ods The plasma paliperidone concentration and serum prolactin level at the ends of 0 ,1 ,2 ,4 ,6 ,8 weeks after taking paliperidone were separately detected in 49 patients with schizophrene (25 males and 24 females) .Then the statistical analysis was performed .Results The serum prolactin level in the schizophrenic patients had statistically significant difference before and after taking paliperidone(P<0 .05) .The increase of plasma paliperidone concentration could cause the increase of serum prolactin level .Conclusion Inthe application of paliper‐idone for treating schizophrene ,plasma paliperidone concentration and serum prolactin level should be monitored for improving the medication safety and decreasing the adverse drug reactions .
RESUMO
Objective] To explore the management mode of IMPACT so as to improve life quality and reduce relapse in schizophrenics . [ Methods] Data on 187 registered schizophrenes were obtained from Regional Mental Illness Management System of Pudong New Area .According to the inclusion and exclusion criteria, 119 of them were selected and divided randomly , into intervention group of 60 patients and control group of 59 patients.The intervention group was treated with IMPACT for 18 months and scored by Schizophrenics Quality of Life Scale ( SQLS) before grouping and 6-months, 12-months and 18-months after grouping . [ Results] After 6 months of intervention treatment , the scores of SQLS in symptoms/side-effects subscale were significantly lower in intervention group than those in control group ( P<0 .05 ) . Although the scores in psychosocial , dynamic/energy 2 subscales were lower as compared with those before grouping , but the difference was not statistically significant .The scores in dynamic/energy and symptoms/side-effects 2 subscales were different as compared with those before grouping ( P <0.05).After 12,18 months of intervention treatment , scores in psychosocial , dynamic/energy , symtoms/side-effects subscales and total scores were markedly lower in intervention group than those in control group(P<0.05).After 12 months of intervention , there were 3 cases/times of relapse in intervention group fewer than 11 cases of relapse in control group , the difference was statistically significant .After 18 months of intervention , the differences in relapse rate were also statistically significant between the two groups . [ Conclusion ] IMPACT approach can improve life quality and prevent relapses in schizophrenics .