Serum PCT, CRP and CD64 levels in predicting early infection after internal fixation of limb fractures / 中华临床感染病杂志

Objective:To investigate serum C-reactive protein (CRP) , procalcitonin (PCT) and neutrophil CD64 in predicting early infection after internal fixation of limb fractures.Methods:A total of 2 572 patients with limb fractures undergoing internal fixation in Taishun County People’s Hospital from January 2016 to December 2022 were enrolled. Postoperative infection occurred in 121 cases (infected group) and did not occur in 2 451 cases (uninfected group). Serum levels of PCT, CRP and CD64 were tested at admission and d1, d3, d5 and d7 after operation. Repeated measurement analysis of variance was used to compare the serum levels of PCT, CRP and CD64 at different time points between two groups, the receiver operating characteristic curve (ROC) was used to evaluate the predictive value of each index or in combination for early infection after internal fixation of limbs fractures.Results:The early infection rate after internal fixation was 4.70% (121/2 572). The levels of PCT, CRP and CD64 in the infection group began to rise after operation and decreased on d7; there were significant differences in PCT, CRP and CD64 levels between the two groups on d3, d5 and d7 after operation (PCT: Ftime=678.607, Fintergroup=2 218.323, Finteraction=653.150; CRP: Ftime=392.724, Fintergroup=1 812.502, FInteraction =379.577; CD64: Ftime=373.686, Fintergroup=4 817.438, Finteraction=528.353, all P< 0.001) . The area under the ROC curve of combined detection of PCT, CPR, and CD64 for predicting early infection was 0.856; the sensitivity and specificity of combined detection were 69.2% and 94.7%, respectively. The combined detection of three indicators showed better prediction values than PCT, CRP and CD64 alone ( Z=6.176, 3.838 and 2.431, P<0.01 or <0.05), and also better than combined detection of PCT and CRP ( Z=2.875, P=0.019). Conclusions:The combined detection of CD64, PCT and CRP is of value in prediction of postoperative infection after internal fixation of limb fractures, which is worthy of clinical application.

Effect of scaling and root planing on serum C-reactive protein levels in patients with moderate to severe chronic periodontitis: a systematic review and Meta-analysis / 华西口腔医学杂志

OBJECTIVE@#To evaluate the effect of scaling and root planing (SRP) on serum C-reactive protein (CRP) levels in patients with moderate to severe chronic periodontitis.@*METHODS@#We searched the PubMed, Web of Science, EMBASE, Cochrane, CNKI, Wanfang, and VIP databases from the inception to July 8th, 2019. Two reviewers independently screened literature, extracted data, and evaluated the bias risk of included studies. Then, a meta-analysis was performed using RevMan 5.3 software.@*RESULTS@#A total of 13 randomized controlled clinical trials and 12 prospective clinical trials were included. Meta-analysis showed that serum CRP levels decreased at 2 and 3 months after SRP (P<0.05), and no significant difference in serum CRP levels was found at 6 months (P=0.49).@*CONCLUSIONS@#SRP can reduce serum CRP levels in systematically healthy patients with moderate to severe chronic periodontitis at 2 and 3 months after SRP.

Prognostic significance of serum C-reactive protein in diffuse large B-cell lymphoma / 肿瘤研究与临床

Objective To investigate the prognostic significance of serum C-reactive protein (CRP) in diffuse large B-cell lymphoma (DLBCL).Methods 106 cases of newly diagnosed DLBCL patients with average age of 55.23 years old were analyzed retrospectively.Determine the level of serum CRP and other factors,including tumour stage,revised Internation Prognostic Index (R-IPI) before the treatment.After median follow-up of 62 months,the relationships between serum CRP and overall survival (OS) and event-free survival (EFS) were observed.Results 106 DLBCL patients were divided into 4 Ann Arbor stages.Median serum CRP levels significantly increased in higher Ann Arbor stages [stage Ⅰ (9.49±2.73) mg/L,stage Ⅱ (14.96± 2.60) mg/L,stage Ⅲ (22.03±3.39) mg/L,stage Ⅳ (28.96±4.56) mg/L] (all P ＜ 0.05).The serum CRP level was positively correlated with tumor stage (r =0.833,P =0.000),R-IPI (r =0.344,P =0.000),and no correlated with age (r =-0.118,P ＞ 0.05),sex (r =0.085,P ＞ 0.05).The patients with serum CRP levels ＞19.0 mg/L had shorter 5-year ESF and OS than patients with serum CRP levels ≤ 19.0 mg/L (P ＜ 0.05).Univariate and multivariate Cox regression models showed that old age,high R-IPI score and high CRP level were independent adverse prognostic factors.Conclusion In DLBCL patients,high CRP level not only reflects tumor burded,but also delivers prognostic information.