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AIM: To investigate the effects of imipenem-cilastatin sodium combined with immunoglobulin on serum PCT, hs-CRP and TNF-α in child with baby sepsis complicated with disseminated intravascular coagulation (DIC). METHODS: Ninty-two cases of patients with sepsis and DIC neonates admitted to our hospital from January 2013 to April 2019 were enrolled in this study. All the children were divided into observation group and control group according to random number table method, 46 cases in each group. The patients in the control group were treated with imipenem-cilastatin sodium, and the patients in the observation group were treated with imipenem-cilastatin sodium combined with immunoglobulin. The efficacy of the two groups, the time of DIC index returned to normal, bleeding stopped and ICU hospitalization time, coagulation parameters (FIB, PLT, D-D, TT), serum inflammatory factor levels and incidence of adverse reactions were compared. RESULTS: The total effective rate of treatment in the observation group was 93.48% (43/46), which was higher than that in the control group (78.26%, 36/46) (P0.05). CONCLUSION: Imipenem-cilastatin combined with immunoglobulin is effective in the treatment of baby sepsis complicated with DIC. It can alleviate or eliminate bleeding and other symptoms, shorten ICU hospitalization time, improve coagulation function, and reduce serum PCT and hs-CRP, TNF-α expression, and the body's inflammatory response, combined with fewer adverse reactions, which has a higher clinical value.
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Objective To observe plasma albumin,total bilirubin and serum inflammatory factors,gonadal hormone levels in men with bipolar disorder,and to provide evidence for the diagnosis of the disease.Methods 48 men with bipolar disorder were selected as disease group,and 42 cases of male physical examination were selected as control group.Plasma albumin,total bilirubin and serum inflammatory factors,gonadal hormone levels of the two groups were detected.Results The levels of serum albumin and total bilirubin of the disease group were (43.4 ± 3.9)g/L and (9.4 ±1.9)μmol/L,which were lower than those of the control group[(49.6 ±3.0)g/L and (11.8 ± 2.1)μmol/L],the differences were statistically significant (t =8.361,5.692,all P 0.05).The serum level of E2 of the disease group was (23.2 ± 16.1)pg/mL,which was lower than (35.9 ±18.0)pg/mL of the control group,the serum T level of the disease group was (10.8 ±4.9)ng/mL,which was higher than (4.2 ±1.6)ng/mL of the control group,the differences were statistically significant(t =3.533,8.344,all P <0.05).Conclusion Plasma albumin,total bilirubin and serum IL -1β,IL -4 levels can be used as references for clinical diagnosis of bipolar disorder,and serum E2 and T levels can be used as risk factors for bipolar disorder.
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OBJECTIVE:To observe clinical effect and safety of Shenfu injection combined with linezolid in the treatment of severe pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA). METHODS:In retrospective study,62 MRSA severe pneumonia patients selected from ICU of our hospital during Jun. 2012-Oct. 2015 were divided into observation group (25 cases)and control group(28 cases)according to medication plan. Based on routine treatment,control group was additionally given Linezolid injection 600 mg,ivgtt,bid. Observation group was additionally given Shenfu injection intravenously with initial dose of 60 mL,and then given continuous intravenous infusion of 60 mL at a rate of 20 mL/h,q12 h,on the basis of control group. Both groups were treated for consecutive 2 weeks. Clinical efficacy,bacteriological efficacy,cardiac function indexes and serum levels of inflammatory factors before and after treatment as well as the occurrence of ADR were compared between 2 groups. RESULTS:The clinical response rate of observation group was 88.00%,which was significantly higher than 60.71% of control group,with statistical significance (P0.05). Before treatment,there was no statistical significance in cardiac function indexes and serum inflammatory factor levels between 2 groups(P>0.05). After treatment,LVEF,SV,CO and CI of 2 groups were increased significantly compared to before treatment,while the levels of TNF-α,IL-6,CRP and PCT were de-creased significantly;the indexes of observation group was significantly better than those of control group,with statistical signifi-cance (P<0.05). No severe ADR was found in 2 groups. CONCLUSIONS:Shenfu injection combined with linezolid effectively improves the cardiac function of patients with MRSA severe pneumonia,enhances the anti-inflammatory effect,and have a very significant clinic effect with good safety.
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Objective To investigate the influence of irbesartan and hydrochlorothiazide on the serum inflammatory factors (CRP ,IL‐6) ,Hcy ,endothelin and hemorheology levels in the patients with hypertension .Methods 148 cases of essential hyperten‐sion were divided into the research group (n=74) and the control group (n=74) according to the random grouping method .The control group was treated by the conventionally symptomatic therapy ,while on this basis the research group was given with the irbesartan and hydrochlorothiazide therapy .The total treatment course of 2 groups were 3 months .The systolic pressure and dias‐tolic pressure ,serum CRP and IL‐6 ,plasma Hcy ,endothelin levels ,hemorheology indexes in the two groups were performed the contrastive analysis .The drug safety was evaluated .Results The systolic pressure and diastolic pressure after the treatments in the two groups were significantly decreased compared with before treatment(P0 .05);the ser‐um CRP and IL‐6 levels after treatment in the research group were significantly lower than those in the control group(P0 .05);the plasma Hcy and endothelin after treatment in the research group were significantly lower than those in the control group(P0 .05) .Conclusion Irbesartan and hydrochlorothiazide can significantly reduce the blood pressure ,serum inflammatory ,Hcy and endothelins levels in the patients with hypertension ,have no influence on the he‐morheologic indexes and no serious adverse reactions ,and are safe and reliable .