Clinical Research Guidelines for Treatment of Shingles with New Uyghur Medicine (Draft) / 中国中医药信息杂志

This research conducted retrospective multi-center study on medical records of Uyghur Medicine diagnosis and treatment program of shingles, and collected information about demography, diagnostics, and therapeutics, efficacy evaluation and nursing to conclude and analyze the main syndromes and sub-disease performance. Shingles was divided into 3 types in Uyghur Medicine field: abnormal blood type shingles, abnormal bile liquid type shingles, and abnormal black choledochal typeshingles. Uighur Medicine syndrome type standards of shingles were established. Rash suspended time, rash dry scab time, the pain start to ease time interval, time completely pain, pain bounce rate, the incidence of postherpetic neuralgia, and PHN recovery time were evaluated. Disease and syndrome clinical criteria of shingles were established by evaluating Uygur Medical symptoms improvement, improvement of patients’ life quality and the changes in patients’ internal environment. On this basis, in accordance with the technical requirements of the national medicine review, the research developed clinical research guidelines for the treatment of shingles with new Uyghur Medicine (draft).

¿Es posible utilizar cannabis como extracto o spray oro-mucoso para aliviar dolores de Herpes Zoster?: síntesis rápida de evidencia / Is it possible to use cannabis as an extract or oromucosal spray to relieve Herpes Zoster pain?: rapid evidence synthesis

ANTECEDENTES Y OBJETIVO La neuralgia post-herpética es un dolor neuropático generado por el cuadro de Herpes Zóster, producido por el virus de la Varicella. En este contexto, el Departamento de Políticas Farmacéutica y Profesiones Medícas solicita esta síntesis de evidencia con el objetivo de conocer el efecto de extracto y spray oro-mucoso de cannabis para aliviar este dolor. METODOLOGÍA Se formuló una estrategia de búsqueda para ser utilizada en las bases de datos Epistemonikos, Health Systems Evidence, Health Evidence, Cochrane, PubMed, EVIPNet Global, LILACS, Google Scholar, PsycInfo y CINAHL, con el objetivo de identificar revisiones sistemáticas del tema. Se excluyeron estudios realizados en animales, que solo contenían THC (y no CBD), otros canabinoides diferentes a Nabiximols y extracto oral, además, no se consideraron análisis de dependencia de cannabis. RESULTADOS Se utilizan 6 revisiones sistemáticas, de las cuales se obtuvieron los siguientes resultados: -No fue posible calcular significancia estadística, la evidencia encontrada muestra que el aceite de cannabis oral reduciría el dolor percibido (en Escala Numérica del Dolor), en comparación a placebo. -No fue posible agrupar resultados, la evidencia encontrada muestra que Nabiximols (Sativex®) reduciría el dolor en pacientes con dolor neuropático no específico y debido a artritis reumatoide, mientras que no tendría diferencia en pacientes con diabetes. -La evidencia encontrada muestra que el número de personas que reportan una reducción del dolor de al menos un 30%, en pacientes con dolor neuropático no específico y en diabetes, no sería significativamente distinto al comparar Sativex® con Placebo. -La evidencia encontrada muestra que existiría un mayor abandono de los estudios clínicos debido a algún efecto adverso, en pacientes tratados con Sativex® que en pacientes del grupo placebo tratados por dolor neuropático sin especificar. No habría diferencias en pacientes con artritis reumatoide. -La certeza de la evidencia presentada es incierta, puesto que ésta no se ha evaluado en esta síntesis.

Vírus varicela zoster / Varicella zoster virus

As patologias oriundas da infecção pelo vírus varicela zoster (VZV) são varicela e herpes-zoster. A infecção primária pelo VZV é responsável pelo desenvolvimento da doença conhecida como catapora e a reativação da infecção latente pelo VZV, em uma fase posterior da vida do infectado, é chamada herpes zoster. Este artigo discute as manifestações clínicas, diagnóstico, tratamento e prevenção da infecção com levantamento em base de dados Medline/Pubmed, SciELO e LILACS. Os descritores varicela, herpes-zoster e complicações foram utilizados para o levantamento bibliográfico. Foram selecionados 35 artigos para revisão, segundo critérios de qualidade metodológica.

Curative Observation and Nursing of Shingles Treated with Venesection and Cupping plus Yunnan White Powder External Application / 国际中医中药杂志

Objective To observe the therapeutic effects of treating shingles with venesection and cuppingplus Yunnan White Powder external application and to observe the effect of mental intervention and nursing on clinical healing time.Methods 100 cases with shingles were randomly recruited into two treatment groups(Group A and Group B)and a control group.Both treatment groups were treated with venesection and cupping plus yunnan white powder external application,in addition,group B was treated with mental intervention and nursing care.The control group was treated with Aciclovir ointment.Results As compared with the control group,both treatment groups showed significant difierences in the time of relieving pain,removing swell,forming a scab,and healing(P＜0.01);Compared with group A,group B showed a shortened healing time with P＜0.05.Conclusion It is effective to treat shingles with venesection and cupping plus yunnan white powder.Mental Intervention and nursing can promote the healing time and improve the degree of satisfaction.

Clinical Experience of Herpes Zoster Developing within Recent Surgical Scar Area

PURPOSE: Herpes zoster is a common dermatologic disease characterized by unilateral pain and vesicular lesions over the unilateral sensory dermatomes being caused by the reactivation of Varicella zoster virus and its incidence seems to be increasing recently. In case of involving the ganglion of the fifth cranial nerve(trigeminal nerve), it can descend down the affected nerve into skin, then producing an eruption in the dermatome. Among the patients, about 40-50% had associated conditions such as diabetes mellitus, hypertension, pulmonary tuberculosis, liver diseases, peptic ulcer, hypothyroidism, pharyngitis but rare facial trauma. METHODS: Retrospective study was done for 3 cases of Herpes zoster from May 2000 to May 2007, which had been treated with acyclovir and steroid. RESULTS: The clinical course was uneventful. Follow- up length was about 3 months. After treatment, the patients became stable and there was no complications. CONCLUSION: Herpes zoster was commonly associated with systemic disorders and the treatment duration was prolonged in associated diseases. But herpes zoster occurring specifically at the site of previously traumatized facial skin has not yet been reported. We experienced the treatment of herpes zoster developing within recent operative facial scar and three cases are presented with the review of literatures. Finally, facial trauma might be a risk factor for herpes zoster in traumatized patients.

Prevalência de IgG do vírus varicela-zoster (VVZ) em indígenas da tribo Araweté, em altamira, Pará, de janeiro-fevereiro de 2001 / Prevalence of IgG of the varicela zoster vírus (VZV)

Objetivo: determinar a prevalência de anticorpos IgG para o vírus da varicela-zoster (VVZ) em indivíduos da comunidade indígena Araweté, Altamira, Pará, Brasil. Método: foram testadas 357 amostras de soros de indivíduos residentes na comunidade indígena Araweté, coletadas em janeiro e fevereiro de 2001, após um surti grave causado por esse vírus. Utilizou-se o procedimento imunoenzimático (ELISA) "Kit" da "Clark LaboratorieisTM" (Jamestown-NY-EUA) na pesquisa de anticorpos IgG para o VVZ. Resultados: as 357 amostra. analisadas mostraram taxa de 83,2% (297/357) de positividade. O sexo feminino foi mais acometido que o masculino, com 88,0% (162/184) e 78,0% (135/173), respectivamente, resultando diferença estatisticamente significativa, p= 0,017. A freqüência de soropositividade até os 20 anos de idade foi de 64,0% (190/297) Conclusão: aproximadamente 17% do total de indivíduos pesquisados, ainda não apresentam imunidade contra o VVZ. Os autores recomendam a necessidade de vacinação de rotina contra varicela na população suscetível afim de conferir proteção contra doença severa em comunidades não imunes.

Objective: the aim of the study was to determine the prevalence of anti- VZV antibodies of immunoglobulin G class (lgG) among remote indian communities living in the central-west region of Pará state, in the municipality of Allamira. Method: serum samples were collected in January 2000 from the Araweté Indians group afier the notification of in outbreak of chickenpox starty with 12 cases. VZV-IgG antibodies were measured by enzyme-linked immunosorbent assay (ELISA), using a commercial kit (Clark LaboratoriesTM, Jamestown-NY-USA). Results: of the 357 tested, 297 (83%) were IgG-positive, of which 45,3% (135/297) were from male indians and 54,7% (162/297) from females individuals. Rates of seropositivity up to 20 years of age was 64,0% (190/297). In addition, frequencies of seropositivity were consistently higher in females than in males (p=0,0I7). Conclusion: about 17% of the total of searched individuals, still they do not present immunity against the VZV. The need for routine vaccination against varicella of susceptible population is recommended, in order to confer protection against severe disease among these non-immune communities.