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OBJECTIVE:To evaluate the effects of felodipine slow-released tablets on improving prethrombotic state of hypertensive patients.METHODS:Felodipine slow-released tablet(5mg)was given to36patients,q.d.for6weeks.Blood pressure,heart rate and hemostatic molecular markers including thromboxane B 2 (TXB 2 ),6-keto-prostglandin F 1? (6-k-PG_ F 1? ),tissue-type plasminogen activator(t-PA)and its inhibitor(PAI-1)as well as hemorheologic indexes were measured be_ fore and after felodipine administration.RESULTS:After the treatment,blood pressure was decreased significantly(P
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Object To study the release mechanism of slow released tablet of puerarin (PUE) prepared by taking chistosan (CS) and sodium alginate (AL) as primary excipient. Methods The effect of the release in different conditions and the release mechanism was observed. Results No effect was found on release rate by basket and blade paddle methods, but the primary release (1 2 h) in different rotation speed showed the effect on drug release and the release rate was dependent on medium pH value (P
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OBJECTIVE: To study the dissolution rate of clarithromycin slow - released tablet in vitro. METHODS: The dissolubility of clarithromycin slow- released tablet was determined by UV - spectrophotometry .RESULTS: The Weibulls distribution function equation of self - prepared and imported clarithromycin slow - released tablets were lnln1/1-F(t)=1.5 291 lnt-3.7 539, (r = 0.9 842) and lnln1/1-F(t)=1.5 216 lnt-3.6 759,(r = 0.9 830) .respectively .The dissolution rates of self-prepared and imported slow - released tablets were comparable.CONCLUSION: The study indicates that the self - prepared slow - released tablet had satisfactory sustained release effect.The method established for assaying the dissolution rate was suitable for quality control of clarithromycin slow - released tablet.