Application Of Central Composite Design For Citalopram Hydrogen Bromide Mouth Dissolving Films

Citalopram is an antidepressant used for treating major depressive disorder. In the current work Citalopram HBr is formulated as mouth dissolving film with enhanced drug dissolution. The Central Composite Design (CCD), employed to examine the effects of amount of HPMC E50 (A), amount of maltodextrin (B) and amount of glycerol (C) on response variables tensile strength, disintegration time and cumulative % drug release. 27 formulations prepared according to CCD and evaluated for physicochemical parameters and in vitro dissolution studies. Citalopram HBr mouth dissolving films formulated by employing solvent-casting method using HPMC E50, maltodextrin and glycerol, optimized for the effective dosage of superdisintegrants. The formulation CF21 with maximum tensile strength of 67.21±1.31 gm, least disintegration time of 9±1.60 sec and highest drug release of 98.41±1.81% is chosen optimal formulation with maximum content uniformity and folding endurance. It is evident from the above results that the developed formulation can be an innovative dosage form to improve the drug delivery, quick onset of action as well as improve patient compliance in the effective management of depression.

Preparation and Quality Evaluation of Olanzapine Oral Disintegrating Films / 中国药师

Objective:To prepare olanzapine oral disintegrating films and evaluate its quality .Methods:The formula of olanzap-ine oral disintegrating films was optimized by Box-Behnken response surface methodology , the effects of the amount of HPMC and PEG400 were selected as the independent variables , and the tensile strength ,the elongation rate and the drug dissolution at 10 min were used as the dependent variables .The tensile strength , elongation rate , folding endurance , disintegration time and drug dissolution of olanzapine oral disintegrating films were evaluated and the in vitro dissolution was compared with that of the marketed olanzapine oral disintegrating tablets .Results:The optimal formula of olanzapine oral disintegrating films was as follows: the amount of HPMC was 11.0％and the amount of PEG400 was 2.3％.The oral disintegrating films had good film-forming performance, high hardness and flexibility, and could quickly disintegrate in 50 s with fast drug dissolution , and the in vitro dissolution was similar to the marketed olanzapine oral disintegrating tablets .Conclusion: The formula of olanzapine oral disintegrating films is reasonable , the preparation process is feasible , and the quality is stable and controlled , which is worthy of further development .

Enhancement of dissolution rate of rapidly dissolving oral film of meclizine hydrochloride by complexation of Meclizine hydrochloride with ß-cyclodextrine.

Motion sickness is a very common disturbance of the inner ear that is caused by repeated motion such as from the swell of the sea, the movement of a car, the motion of a plane in turbulent air, etc. Most medications for motion sickness need to be taken at least 30 minutes prior exposure to the activity that can cause the problem. This project is based on the hypothesis that Mouth Dissolving Films (MDF) are rapidly dissolving dosage forms which when placed in the mouth release the drug immediately. These dosage forms would be preferred by pediatric and geriatric patients since these are not associated with fear of choking. The fast dissolving films prepared by solvent casting method with suitable appearance, mechanical strength, peelability and disintegration time were obtained using Methocel E-5 as a primary film former. Meclizine HCl, a poorly water soluble and bitter drug could be successfully incorporated in the fast dissolving films with the help of solubilizers such as β-Cyclodextrine and PEG-400.