Analysis on medication regularity and action mechanism of Tibetan medicine in treatment of spleen and stomach diseases based on data mining and integrated pharmacology / 中国中药杂志

To explore the medication regularity of Tibetan medicine in the treatment of spleen and stomach diseases, analyze the potential drug targets and interactions of the prescriptions, and reveal the mechanism of Tibetan medicine in the treatment of spleen and stomach diseases. The prescriptions in Tibetan medicine for treatment of spleen and stomach diseases were collected, and Traditional Chinese Medicine Inheritance Support System (TCMISS) was used to analyze the association rules between the herbs and discover the core herbs and new prescriptions. The integrated pharmacology platform V1.0 software was used to construct "herb-compound-target" network and investigate the interactions between various herbs and related pathways of Tibetan medicine Wuwei Shiliu powder in the treatment of spleen and stomach diseases. Among the 216 prescriptions of Tibetan medicine in the treatment of spleen and stomach diseases, pomegranate seed was used at a highest frequency (118 times), followed by white cardamom (107 times) and comatose (107 times). 12 new prescriptions were evolved by using the association rules (support>=34%, confidence>=0.85). 5 242 related drug targets and 20 related pathways were obtained from classic formula Wuwei Shiliu Powder (FDR<0.01). It was proposed that Tibetan medicine treatment for spleen and stomach diseases was mainly based on proliferation of "stomach fire" and the main drugs were for regulating Qi-flowing for strengthening spleen. The mechanism may be associated with regulation of digestive juice secretion, proton pump, mitochondria, regulation of intestinal digestion and immunity, the body's immunity to microorganisms function and other multiple targets and pathways to achieve the joint intervention.

Professor Lin Huiguang’s Experience in the Treatment of Chronic Atrophic Gastritis / 浙江中医药大学学报

Objective]To summarize the treatment of Professor Lin Huiguang in treating chronic atrophic gastritis(CAG).[Method]The author studies from the teacher, collecting related medical records, analysing etiology and pathogenesis of Professor Lin Huiguang in chronic atrophic gastritis, and sums up dialectical and treatment of chronic atrophic gastritis and exemplify that. [Results]Professor Lin Huiguang thinks that the occurring of chronic atrophic gastritis because of diet, emotion, exogenous evil and so on. It causes the stomach out of harmony, dysfunction of the spleen, and qi stagnation and blood stasis, the spleen and stomach qi deficiency type, dysfunction of the spleen type, liver-spleen disharmony type, cold and heat type, stomach yin deficiency type of chronic atrophic gastritis have been put forward, and the relevant treatment also is proposed.[Conclusion]Professor Lin Huiguang has rich clinical experience and unique insights on the treatment of chronic atrophic gastritis in traditional Chinese medicine. Curative effect is distinct and it is worth learning and promoting.