A Case of Subungual Glomangiomyoma with Myxoid Stromal Change / 대한피부과학회지

Glomus tumors are relatively rare benign tumors originated from glomus cells. Histopathologically, they are classified into solid glomus tumor, glomangioma, and glomangiomyoma. We report a case of subungual glomangiomyoma showing myxoid stromal change in a 38-year-old woman. The patient presented with a solitary, tender nodule on the nail bed of the right thumb. Histopathologically, there were many spindle cells which were mixed with glomus cells near the vascular spaces and myxoid stromal changes. Immunohistochemically, both glomus cells and spindle cells showed a positive reaction for CD34, smooth muscle actin, vimentin but did not show a reaction for desmin. To our knowledge, a few cases of subungual glomangiomyomas have been, but those with myxoid stromal change are very rare.

A Case of of Glomangiomyoma Showing Smooth Muscle Cell Proliferation and Mucinous Stromal Change / 대한피부과학회지

Glomus tumors are benign neoplasms that are derived from modified smooth muscle cells known as glomus cells. Histologically, it can be subdivided as glomus tumor proper, glomangioma, and glomangiomyoma according to relative proportions of components. Glomangiomyomas are the least frequent type and their overall architectural pattern may resemble glomus tumor proper or glomangioma, but there is a gradual transition from glomus cells to elongated mature smooth muscle cells. This transition is most obvious in the region surrounding large vessels. We present a case of glomangiomyoma of the left upper arm and the left fourth finger, in which ten-year history of two painful, bluish-colored subcutaneous nodules. On histologic examination, this case showed marked smooth muscle cell proliferation around large vessles and mucinous stromal change.

Light and Electron Microscopical Studies on the Stroma of Hydatidiform Mole

Many investigators were interested in the pathogenesis and the relationship between microscopical features and clinical behavior of hydatidiform mole. Trophoblastic cells in the trophoblastic disease were intensively examined histologically, ultrastructurally, immunohistochemically, and with hormone assay method, etc. But ultrastructural study on the stroma of hydatidiform mole was scarcely reported. In this paper, hydatidiform mole was examined at light and electron microscopic levels, with emphasis on the stroma. The results were as follows: 1) Hydropic degeneration of H-mole is more severe in the center of stroma and is not related with the degree of trophoblastic proliferation. Hofbauer cell and vascular structure are extremely rarely observed in the periphery of stroma which has relatively preserved cellular components. 2) Basement membrane is sometimes separated from trophoblastic layer. Degenerated cells in the stroma contain vacuoles, autophagosomes, and lipid droplets. Collagen is abundant in the loose interstitium. Hofbauer cells have no lysosome or phagosome. Vascular lumen is patient and endothelial cells are degenerated. From the above results, H-mole may be produced due to abnormal changes of trophoblasts and stromal changes may be a secondary process, so called autolysis. Hofbauer cells are not engaged in the stromal degeneration and may be different from usual tissue macrophages.