Effect of Strychinine, a Glycine Inhibitor, on the Programmed Cell Death of Motoneurons during the Chick Development

In this study, we report that the treatment of strychinine (STR), an inhibitor of glycine receptor, induced premature onset of programmed cell death (PCD) of developing chick motoneurons (MNs). Treatment of STR on E4 chick embryo increased the apoptosis of MN on E5 when MN PCD does not occur normally. On the other hand, treatment of STR from E3 or E5 for 24 hours did not significantly influence the extent of MN PCD, indicating that the STR effect is developmental stage-specific. However, the expression of glycine receptor isoform was low on E3-4, and other glycine receptor antagonists did not exhibit PCD-promoting activity, suggesting that the STR action on PCD is not related to the glycine receptor activation. Identification of the target molecule for STR action may provide novel mechanism how the onset of developmental PCD is regulated.

Effects of intrathecal administration of strychnine on propofol induced antinociception / 中国药理学通报

0.05),but the HPPT was dose-dependently increased in 25 and 50 mg?kg -1 groups(P0.05); on the contrary ,strychnine 0.5,0.75,1.0 ?g(it) decreased the HPPT of propofol-treated mice as doses increased(P0.05). CONCLUSION Propofol can induce antinociception in hot-plate test and acetic acid-induced writhing test of mice. Spinal glycine receptors may play a role in propofol's antinociceptive properties in hot-plate test of mice.