Short-term and long-term outcomes of uniportal versus three portal thoracoscopic radical resection of non-small cell lung cancer: A retrospective cohort study / 中国胸心血管外科临床杂志

@#Objective     To compare the short-term efficacy and long-term survival of patients with non-small cell lung cancer (NSCLC) treated by uniportal or three portal thoracoscopic radical resection. Methods     A total of 388 patients who underwent uniportal or three portal thoracoscopic radical resection of lung cancer in the Department of Thoracic Surgery of Anhui Chest Hospital from 2015 to 2016 were analyzed retrospectively. The patients were divided into two groups including an uniportal group and a three portal group according to the procedure. The clinicopathological features, perioperative data and long-term survival of the two groups were compared. Results     Finally, we included 205 patients with 105 males and 100 females at an average age of 58.73±10.93 years. There were 102 patients in the uniportal group and 103 patients in the three portal group. There was no statistical difference in clinicopathological features between the two groups (P>0.05). But compared with the three portal group, the uniportal group had less postoperative drainage, shorter postoperative catheterization time and postoperative hospital stay (P<0.05). There was no statistical difference in the number of lymph node dissection stations between the two groups (P=0.058). The pain score at 24 hours after operation in the uniportal group was significantly lower than that in the three portal group (P<0.001). There was no  statistical difference in the total incidence of complications and the incidence of pulmonary complications between the two groups (P=0.161 and P=0.275). The median survival period and the 1st, 3rd, and 5th year survival rate in the uniportal group was 63.0 months and 95.0%, 75.2%, 51.5%, respectively. The median survival period and the 1st, 3rd, and 5th year survival rate in the three portal group was 61.0 months and 89.3%, 70.9%, 50.5%, respectively. There was no satistical difference in the survival results between the two groups (P=0.440). Conclusion     Uniportal thoracoscopic radical resection of lung cancer is more minimally invasive and safe and effective in the treatment of NSCLC. It can make patients recover faster after operation.

Analysis on disease burden of occupational coal workers′ pneumoconiosis in Anhui Province / 中国职业医学

@# Objective To analyze the disease burden caused by occupational coal workers' pneumoconiosis (CWP) in Anhui Methods Province. A total of 1 649 patients with occupational CWP diagnosed in Anhui Province from 1950 to 2019 were selected as the study subjects using a retrospective study method. Age, gender, survival time, location, working age of disease onset, age of death, stage and date of diagnosis of CWP, comorbidities at the time of investigation, hospitalization and outpatient expenses in the past year, cost of absence from work, cost of absence from work of caregivers, and cost of nutrition and transportation were investigated. The years of life lost, years lived with disability (YLDs), disability adjusted life years (DALYs) Results and economic losses were calculated. Among these patients, 1 405 cases survived and 244 cases died. In the age range - - - of 20.0 70.0 years, the YLDs of surviving patients were 2.12 22.20 (8.19±3.59) person years. The YLDs of patients with disease vs - P complications was higher than that of patients without complications [(8.55±3.95) (7.87±3.21) person years, <0.01]. The total - - DALYs of the patients was 14 031.59 person years, and the average per capita DALYs was 8.51 person years. Its YLDs accounted for 82.0 % of the total DALYs. The total economic loss caused by CWP in the 1 405 surviving patients was 354.903 0 Conclusion million yuan, and the average per capita economic loss was 252 600 yuan. The disease burden caused by CWP is relatively high in Anhui Province. In addition to early detection, diagnosis and treatment, it is necessary to focus on prevention and treatment of CWP complications to reduce the disease burden.

Influence of liquid nitrogen cryopreservation to survive capability of Babesia microti standard strain / 中国人兽共患病学报

We discussed the influence of liquid nitrogen cryopreservation to survive capability of Babesia microti standard strain.The whole blood of mice infected with Babesia microti was put in liquid nitrogen to cryopreservation for 1 month,3 months,6 months,9 months,the whole blood was get out respectively and recovery at room temperature,and infected 3 mice respectively,100 μL/ mouse (the first generation after redissolution,the experiment group).In the same time,3 mice were also infected with Babesia microti as the animal conservation control group.When the infection rate was at a high level,the whole blood of the experiment group mice were injected into 3 normal BALB/c mice (the second generation after redissolution),to observe the changes of the Babesia microti form and proliferation situation,and also to observe the infection rate of the first and the second generation after redissolution in different conserving time.Compared with Babesia microti of animal subcultivation,the form of Babesia microti of liquid nitrogen cryopreservation changed a little.Small trophozoites,annular trophozoites,schizont and immature and mature merozoite and other form can also be seen.Compared with Babesia microti of animal subcultivation,the first time to see the worms and the time attaining to the high infection level were 1 to 2 days later,but for the second generation after redissolution,it is the same.There was no significant difference in different conserving time of 1,3,6,9 months.The influence of liquid nitrogen cryopreservation to survive capability and worm form of Babesia microti is a little,so liquid nitrogen cryopreservation can be a better way to conserving Babesia microti.

Efficacy and Safety of a Steroid-Free Immunosuppressive Regimen after Liver Transplantation for Hepatocellular Carcinoma

BACKGROUND/AIMS: We aimed to evaluate the efficacy and safety of an immunosuppressive regimen without steroids after liver transplantation (LT) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). METHODS: Sixty-six HCC patients who underwent an immunosuppressive regimen without steroids after LT were enrolled in the steroid-free group. The preoperative characteristics and postoperative outcomes of these patients were compared with those of 132 HCC recipients who were placed on an immunosuppressive regimen using steroids (steroid group). The incidence of acute rejection, HBV recurrence, infection, and new-onset diabetes mellitus and the overall and tumor-free survival rates were compared between the two groups. RESULTS: Differences were not observed in the 1-year (83.3% vs 97.0%, p=0.067), 3-year (65.4% vs 75.8%, p=0.067) or 5-year (56.3% vs 70.7%, p=0.067) patient survival rates or in the 1-year (62.1% vs 72.7%, p=0.067), 3-year (49.8% vs 63.6%, p=0.067) or 5-year (48.6% vs 63.6%, p=0.067) tumor-free survival rates between the two groups, respectively. In the steroid-free group, the patients who fulfilled the Milan criteria had higher overall and tumor-free survival rates than those in the steroid group (p<0.001). The prevalence of HBV recurrence (3.0% vs 13.6%, p=0.02) was significantly lower in the steroid-free group compared with the steroid group. CONCLUSIONS: After LT, an immunosuppressive regimen without steroids could be a safe and feasible treatment for HBV-related HCC patients, thus resulting in the reduction of HBV recurrence. Based on the observed survival rates, patients who fulfill the Milan criteria may derive benefits from steroid-free immunosuppression.

Related factors and clinical countermeasures of replantation operation survival / 中国基层医药

Objective To investigate the related factors on survival rate of digital replantation and clinical measures.Methods 27 patients with digital replantation were selected,patients'various aspects relevant factors on the survival rate of digital replantation were analyzed by the single factor analysis and multi-factor Logistic regression.Results 35 fingers were needed to be replanted,the successful rate was 85.7％.There were significant differences in survival rate based on different treatment after injury,different injury reason,use of the vein graft,duration of warm ischemia,whether thrombosis,whether vascular crisis between survival group and non-survival group (x2 =6.386,3.889,4.704,6.176,10.802,4.564,all P ＜ 0.05).The results of multivariate Logistic regression analysis showed that processing method after injury,injury reason,use of the vein graft,warm ischemia time,whether thrombosis,whether vascular crisis were the factors directly affected the survival rate (r =0.902,0.957,0.922,1.825,2.053,1.026,all P ＜ 0.05).Conclusion In order to improve the digital replantation survival rate,patients should be investigated and assessed before digital replantation.The indications should be reasonable selected,factors are compositely considered,preventive measures are taken timely.

Uso de florestas secundárias por aves de sub-bosque em uma paisagem fragmentada na Amazônia central / Use of secondary forests by understory birds in a fragmented landscape in central Amazonia

Na Amazônia, as taxas de desmatamento crescem desde 1991 e as previsões não são otimistas quanto à desaceleração desse processo. A devastação da floresta é acompanhada de uma expansão de florestas secundárias (FS) que se estabelecem nas áreas abandonadas. A tendência é um aumento de florestas secundárias, resultando num mosaico de floresta contínua e fragmentos separados por uma matriz de FS. Nesse cenário, autores acreditam que a Amazônia pode passar por um processo massivo de extinção de espécies. Por outro lado, a previsão de um processo massivo de extinção pode ser equivocada, pois muitas espécies florestais poderiam sobreviver nas florestas secundárias. Para avaliar o valor das florestas secundárias para espécies florestais amostramos por oito meses com redes de neblina uma capoeira (FS) em regeneração e uma floresta primária (FP) de uma paisagem fragmentada. Algumas espécies não foram capturadas na capoeira e aparentemente evitam esse tipo de hábitat. No entanto, a maioria das espécies do grupo focal não apresentou diferença na sobrevivência aparente entre os ambientes, o que nos indica que estão habitando a capoeira e a floresta primária da mesma forma. Na realidade amazônica, onde grande parte da matriz é composta por floresta secundária, a matriz tem valor para conservação e deve ser analisada como um elemento dinâmico que não apenas permite a movimentação de indivíduos, mas também serve de hábitat para muitas espécies de floresta primária. Mas ressaltamos que é fundamental a preservação de áreas de floresta primária que servirão de fonte às florestas secundárias adjacentes.

Rates of deforestation in the Brazilian Amazon have increased since 1991 and forecasts are not optimistic about the slowing of this process. Some authors believe that the Amazon may be experiencing a massive process of species extinction. However, the deforestation is accompanied by the expansion of secondary forests that are established in the abandoned areas. The trend is an increase in secondary forests cover, resulting in a mosaic of primary forest (FP) and fragments separated by an array of secondary forests (FS). In this scenario, the prediction of a massive extinction could be wrong if many species could survive in the secondary forests. To assess the importance of FS for the understory birds we sampled areas in regeneration and a continuous forest of a fragmented landscape. We conducted mist netting (24 nets/day) for six consecutive days/month, for 8 months (May-November) in 2009. Some forest species as do not seem to be adapted to the secondary forest environment and their occurrences are restricted to continuous forest environments. But most focal species showed no significant difference in apparent survival rates between the enviroments, suggesting that these species inhabit the secondary forest and the primary forest similarly. Because most of the matrix in fragmented landscapes are composed by secondary forests, such results highlights the conservation value that these habitats present in the long term. Thus, FS should be regarded as dynamic matrix that not only allows the movement of individuals but also function as habitat for many species typical of FP.

Preoperative predictors of malignancy and invasive carcinoma in intraductal papillary mucinous neoplasms / 中华胰腺病杂志

Objective To investigate the predictive factors for malignancy and invasive carcinoma of IPMN, and the survival rates of different pathological type of IPMN were compared. Methods Seventy-eight patients with IPMN admitted to Changhai Hospital from January 1993 to September 2009, who underwent surgery with histological evidence were retrospectively analyzed. The univariate and multivariate analysis of potential predictive factors, including medical history, clinical presentations, liver function, CEA, CA19-9,and imaging findings was conducted to identify the predictive factors for malignancy and invasive carcinoma of IPMN. Results Univariate analysis identified jaundice, acute pancreatitis history, CA19-9 Level > 37U/ml,AKP, unclear border of tumour as independent predictive factors for malignancy and invesiveness, main pancreatic duct dilation, branch pancreatic duct diameter > 30 mm, presence of mural modules were identified as malignancy predictor. CEA > 6 ng/ml was identified as invasive carcinoma predictor. Multivariate analysis identified one independent predictive factor for malignancy or invasive carcinoma: unclear border of tumour.Another factor of invasive IPMN was acute pancreatitis. The 5 year survival rate for benign 1PMN was 100%,while 2 year survival rate for malignant IPMN was 78.9%, 5 year survival rate was 68.5%. The 2 year survival rate for invasive IPMN was 64.6%, 5 year survival rate was 43.1%. Conclusions Unclear border of tumour was predictive factors for malignancy; acute pancreatitis and unclear border of tumour were predictive factors for invasive carcinoma.

Research of the Relationship Between the Emotion Disorder and Cognitive Function Impairment Relation and its Influence Factors with the Epilepsy Patients / 医学研究杂志

Objective To study the relationship between the emotion disorder and cognitive function impairment relation and its influence factors with the epilepsy patients.Methods We collected 320 cases epilepsy patients in hospital and 56 cases contrast normally in People’s Hospital of the centre of Zhanjiang, and Carry on the determine of the cognitive function separately, the determine of the emotion status, and the measurement for the quality of life, then carry on statistical analysis.Results In 320 cases with epilepsy patients, 259 cases persons has intellectual Impairment (80.9) (IQ

Apoptosis in non-small cell lung cancer: implications for chemosensitivity and prognosis

Lung cancer is one of the most commonly occuring malignancies in the world. In ccontrast to other type of cancer, the death rates from lung cancer decrease has been observed in its death rates in the United States and Canada, but not in developing countries, where, in contrast, it continue to rise. These differences among countries are attribued to smoking habits that are decreasing in developed countries, as result of anti-smoking programs launched by goverments to diminish tobacco use and educate the population.Lunf cancer remains a health care problem. Worldwide, only 13-15% of the patients who develop lung cancer survive 5 years. Approximately 75-80of lung carcinomas are non-small cell lung carcinomas (NSCLC), whereas the remaining 20-25% are small cell lung carcinmas (SCLC). The distiction between SCLC and NSCL is a pragmatic clinical classification to standardize management and therapy, since several differences in the treatment strategies exist between NSCL and SCLC. The major distinction between in term of treatment is that far more ofen NSCL is candidate for surgery. In addition, differences also exist in the epidemiology, etiology, pathology, clinical features, stating, prognostic factors and response to chemotherapy. The focus of this thesis is on NSCLC.