Lazer, política e sociedade: as contribuições da SEJEL para os feirantes do Ver-o-Peso / Leisure, politics and society: the contributions of the fairground SEJEL for O-Ver-Weight

O presente estudo objetiva analisar as contribuições políticas das práticas sociais do lazer promovidas pela Secretaria Municipal de Esporte, Juventude e Lazer (SEJEL) para os feirantes do Ver-o-Peso (2018 a 2019) privilegiando o lazer no cotidiano dos feirantes enquanto direito social. Questões norteadoras: Existe alguma contribuição política pela SEJEL que garanta o Lazer enquanto direito Social em prol dos feirantes do Ver-o-Peso. Se existe? Como existe? Problema ­Como contribuir para as políticas da SEJEL que garanta o Lazer enquanto direito social, em prol dos feirantes do Ver-o-Peso? Metodologia: pesquisa documental qualitativa, enfoque materialismo dialético, método dialético, coleta de dados: jornal, vídeo, blog da SEJEL, leis, projeto de lazer da prefeitura para os feirantes. Resultado: as políticas da SEJEL estão enquadradas com um significado recreativo, havendo necessidade da efetivação de políticas públicas de lazer consolidadas com os feirantes para a compreensão enquanto direito social, e, também por parte dos governantes quando o mesmo está sendo vivido e entendido pelas vias do senso comum somente como descanso, entretenimento e mercadoria. A promoção social do lazer pode estar atrelada a um serviço muitas vezes de forma limitada e alienante de convívio social.

Objective: to analyze the contributions of the social practices of leisure promoted by the municipal Sport, Youth andSport (SEJEL) to the vendors of the Ver-o-Peso (2018 to 2019) for the quality and style of life of them, as well as for that leisure becomes privileged in everyday merchants and practice as a social right of citizenship under the foundations of public policies of leisure. Methodology: qualitative desk research, focus dialectical materialism, dialectical method, data collection, newspaper, video, blog SEJEL, laws, leisure project of city hall to the fairground. Result: The public policies of social practices of leisure SEJEL (2008 to 2012) is framed with a recreational significance, requiring the execution of public policy leisure consolidated with the vendors to understand as a social right, and also by the rulers when it is lived and understood by way of common sense only as entertainment and merchandise. The social promotion of leisure can be linked to a service often quite limited and alienating.

Vivências no Sistema Único de Saúde (SUS) como marcadoras de acontecimento no campo da Saúde Coletiva / Experiences in the Brazilian National Health System (SUS) as events markers in the field of Collective Health / Vivencias en el Sistema Brasileño de Salud (SUS) como marcadoras de acontecimiento en el campo de la Salud Colectiva

Num cenário político favorável a inovações e expectativas de mudanças nas políticas públicas de saúde, surge a iniciativa das Vivências e Estágios na Realidade do Sistema Único de Saúde (VER-SUS), experienciada por estudantes de graduação em diferentes regiões do Brasil. Neste estudo, com abordagem qualitativa, foram realizadas entrevistas, pesquisa documental e bibliográfica como ferramentas de produção de dados, cuja análise ocorreu na perspectiva teórico-metodológica pós-crítica de inspiração rizomática. A discussão sintetiza elementos históricos da época (2003-2005), cuja ideia de práticas formativas do VER-SUS se mostrou potente nas experiências analisadas; intimamente ligadas ao protagonismo do movimento estudantil e das discussões naquele período. O VER-SUS é visto pelos sujeitos da pesquisa como acontecimento no campo da Saúde Coletiva, ou ponto de virada, ao configurar-se como novidade e invenção naquele cenário.(AU)

The initiative of experiences and stages in the reality of the Brazilian National Health System (VER-SUS) was developed by undergraduate students in different regions of Brazil. The experience was developed within a favorable political scenario for changes in public health policies. This qualitative approach study, used interviews, documentary and bibliographic research as tools for data. The analysis benefited from the theoretical-methodological perspective post-criticism with rizomatic inspiration. The discussion synthesizes historical elements of the situation at that time (2003-2005), in which the idea of formative practices of the VER-SUS proved to be potent in the analyzed experiences; intimately linked to the leading role of the students' movement and current debates in that period. The research subjects see VER-SUS as an event in the field of Health Public, as a turning point, configuring a novelty and invention in that context.(AU)

En un escenario político favorable a innovaciones y expectativas de cambios en las políticas públicas de salud, surge la iniciativa de las Vivencias y Estadios en la Realidad del Sistema Brasileño de Salud (VER-SUS) experimentada por estudiantes de graduación en diferentes regiones de Brasil. En este estudio, con abordaje cualitativo, se realizaron entrevistas, investigación documental y bibliográfica como herramienta de producción de datos, cuyo análisis se realizó bajo la perspectiva teórico-metodológica post-crítica de inspiración rizomática. La discusión sintetiza elementos históricos de la época (2003-2005), cuya idea de prácticas formativas del VER-SUS se mostró potente en las experiencias analizadas, íntimamente vinculadas al protagonismo del movimiento estudiantil y de las discusiones en aquel período. El VERS-SUS es visto por los sujetos del estudio como acontecimiento en el campo de la Salud Colectiva o ponto de inflexión, al configurarse como novedad e invención en aquel escenario.(AU)

Gold nanorods together with HSP inhibitor-VER-155008 micelles for colon cancer mild-temperature photothermal therapy

Enhancing the heat-sensitivity of tumor cells provides an alternative solution to maintaining the therapeutic outcome of photothermal therapy (PTT). In this study, we constructed a therapeutic system, which was composed of methoxy-polyethylene-glycol-coated-gold-nanorods (MPEG-AuNR) and VER-155008-micelles, to evaluate the effect of VER-155008 on the sensitivity of tumor cells to heat, and further investigate the therapeutic outcome of MPEG-AuNR mediated PTT combined with VER-155008- micelles. VER-155008- micelles down-regulate the expression of heat shock proteins and attenuate the heat-resistance of tumor cell. The survival of HCT116 cells treated with VER-155008- micelles under 45 °C is equal to that treated with high temperature hyperthermia (55 °C) . Furthermore, we proved either the MPEG-AuNR or VER-155008- micelles can be accumulate in the tumor site by photoacoustic imaging and fluorescent imaging. anti-cancer evaluation showed that tumor size remarkably decreased (smaller than 100 mm or vanished) when treated with combing 45 °C mild PTT system, which contrasted to the tumor size when treated with individual 45 °C mild PTT (around 500 nm) or normal saline as control (larger than 2000 nm). These results proved that the VER-155008- micelles can attenuate the heat-resistance of tumor cells and enhance the therapeutic outcome of mild-temperature photothermal therapy.

Imersão na realidade: o Sistema Único de Saúde e a organização do Programa Mais Médicos em São Paulo, Brasil / Immersion in reality: the Brazilian National Health System and the organization of the More Doctors Program in São Paulo, Brazil / Inmersión en la realidad: el Sistema Brasileño de Slaud y la organización del Programa Más Médicos en São Paulo, Brasil

Desde 2003, o Vivências e Estágios na Realidade do Sistema Único de Saúde (VER-SUS) tem dado oportunidade a universitários de vivenciar a realidade do Sistema Único de Saúde (SUS). Com essa finalidade, surge a vivência em questão, ocorrida no âmbito do Programa Mais Médicos, envolvendo sua organização na realidade do Sistema de Saúde brasileiro. Para isso, um grupo composto por estudantes de várias áreas da Saúde esteve por sete dias em ambientes de planejamento e execução do programa no Estado de São Paulo. As atividades realizadas incluíram participação em reuniões, visita a unidades de Saúde, avaliação sobre a implementação do programa e espaços para debate. Assim, relata-se a experiência sob a perspectiva de um acadêmico que participou da vivência, em uma narrativa cronológica e reflexiva, com fundamentações teóricas inseridas no contexto de cada questão abordada.(AU)

Since 2003, the program Experiences and Internships in the Reality of the Brazilian National Health System (VER-SUS) has given university students the opportunity to experience the reality of the SUS. These experiences are part of the More Doctors Program framework, involving its organization in the reality of the Brazilian healthcare system. A group of students from several health areas spent seven days at planning and implementation meetings for the program in the state of São Paulo. The activities carried out included participation in meetings, tours to healthcare units, assessment of program implementation, and spaces for discussion. This paper is a report on the experience from the perspective of a student who participated in the experience, by means of a chronological and reflective narrative and theoretical grounds within the context of each issue raised.(AU)

Desde 2003, el VER-SUS ha proporcionado a universitarios la oportunidad de vivir la realidad del Sistema Brasileño de Salud. Con esta finalidad, surge la experiencia en cuestión, ocurrida en el ámbito del Programa Más Médicos, envolviendo a su organización en la realidad del sistema de salud brasileño. Para tanto, un grupo formado por estudiantes de varias áreas de la salud estuvo durante siete días en ambientes de planificación y realización del programa en el Estado de São Paulo. Las actividades realizadas incluyeron participación en reuniones, visita a unidades de salud, evaluación sobre la implementación del programa y espacios para debate. De esa forma, se relata la experiencia bajo la perspectiva de un académico que participó de la vivencia, en una narrativa cronológica y reflexiva con fundamentaciones teóricas inseridas en el contexto de cada cuestión abordada.(AU)

Study of correlation between biochemical markers of bone metabolism and postmenopausal osteoporotic vertebral fractures / 重庆医学

Objective To study correlation between biochemical markers of bone metabolism and postmenopausal osteoporot-ic vertebral fractures.Methods The clinical data of 100 cases with postmenopausal osteoporotic were study retrospectively.Fifty patients were postmenopausal osteoporotic,the rests were postmenopausal osteoporotic vertebral fractures.Lumbar spine,hip BMD,serum P1NP,β-CTX,N-MID,25-(OH)VitD and Ca2 + were recorded.Results There was a significant difference among ser-um P1NP,β-CTX and 25-(OH)VitD(P 0.05).Conclusion Serum P1NP and 25-(OH)VitD could predict risk of postmenopausal osteoporotic vertebral fractures.Biochemical markers of bone metabolism combined with BMD could reduce postmenopausal osteoporosis fractures.

Ser, fazer, compor VER-SUS: redes de afetos e conhecimentos / Being, doing, composing VER-SUS: networks of affection and knowledge

A presente obra abriga o trabalho coletivo de reunir diversas experiências das Vivências e Estágios na Realidade do Sistema Único de Saúde do Brasil (VER-SUS/Brasil) em uma edição temática dos Cadernos da Saúde Coletiva. A aposta em incentivar diferentes formatos de produção sobre o VER-SUS teve inspiração no poeta Manoel de Barros: "Que a importância de uma coisa há que ser medida pelo encantamento que a coisa produza em nós." (BARROS, 2006, s/p.). Assim, buscou-se dar visibilidade às criativas e inovadoras ações no campo da saúde coletiva e/ou formação de profissionais, em relação à formação, à gestão, à participação e ao trabalho em saúde, por meio de produções textuais e imagéticas. Neste primeiro volume da edição temática VER-SUS ­ Ser, fazer, compor VER-SUS: Redes de afetos e conhecimentos, os leitores irão encontrar relatos de experiências, poesias, ensaios visuais, que abordam tópicos sobre metodologias das vivências, participação de atores, contribuição para a formação profissional, além de temas que permeiam a construção do Sistema Único de Saúde, a partir de olhares de versusianos.

Inovações no cotidiano da saúde na Amazônia: encontros do trabalho com a educação permanente e a humanização / Innovations in the daily life of health in the Amazon: work encounters with permanent education and humanization

Neste segundo volume do Cadernos da Saúde Coletiva, apresentamos aos leitores, múltiplos cenários do VER-SUS, narrados a partir de diferentes perspectivas e formatos e que, juntos, poderão contribuir com o propósito de conhecermos um pouco mais sobre as histórias, pontos de vistas, reflexões e sentimentos acerca do VER-SUS em suas singularidades e potencialidades, em aspectos instituídos e instituintes, desejosos e desejantes, ocorridos pelo Brasil nesse último período. Pretende-se, com este segundo volume ­ Múltiplos cenários do VER-SUS: Vivências e Estágios de norte a sul do Brasil -abrir, ao campo dos possíveis, diversos relatos de experiências, com suas histórias, efeitos, construções, elaborados por centenas de atores que participaram das Vivências no SUS. Ou, quem sabe, construir dezenas de pontos de vista para potencializarmos ainda mais produções e efeitos do VER-SUS.

Função-facilitador(a) nos Estágios e Vivências na Realidade do Sistema Único de Saúde: Marcas de protagonismo estudantil na construção de práticas formativas / Role-facilitator in Internships and Experiences in the Reality of the Unified Health System: Marks of student protagonism in the construction of training practices

Mais do que o texto de uma dissertação de mestrado com o tema VER-SUS, temos aqui uma produção acadêmica que marca a história do Programa. Thaís atravessou o Mestrado com essa motivação e reverberou a temática do VER-SUS, da formação profissional e do trabalho no cotidiano do sistema de saúde nas atividades de ensino e nos encontros por que passou. Não se trata de um relato de experiência, senão de uma análise com uma construção epistemológica interessante. Da experiência e do relato de seus pares, à época, Thaís reflete sobre a função do facilitador. Para isso, é inevitável, a produção de um território de formulações que atravessa a Saúde Coletiva e encontra a Educação, mas também a Sociologia e a Filosofia. Bom, para restringir a descrição às áreas do conhecimento segundo a árvore do CNPq. Sim, pois se formos além, a poesia e a literatura comparecem com metáforas significativas e choques no pensamento que abrem a produção do pensamento ao seu "fora"; aprendizagem pela inteligência!

Ojo, mirada y pulsión: un recorrido metapsicológico Freudiano / Eye, gaze, and drive / Oeil, regard et pulsion

Este ensayo explora algunas de las bases metapsicológicas sobre el tema de la mirada y de la importancia de la función del ojo en la producción teórica freudiana, a sabiendas de que ojo y mirada no son lo mismo. El presente abordaje se realiza partiendo de la diferencia entre visión y mirada para luego, conceptualmente, rastrear la función del ojo y el impacto de la mirada en la constitución de la subjetividad, sobre todo al nivel de la pulsión. Muy especialmente refiere a la teoría de las pulsiones, y a su repercusión teórica posterior, para inmediatamente aproximarse a sus primeros escritos psicoanalíticos, empezando con “Tres ensayos de teoría sexual”. La sección substancial de este ensayo lleva al problema netamente metapsicológico de la “pulsión de ver” (Schautrieb) expuesto en textos como el mencionado de 1905 y “Pulsión y destinos de pulsión” de 1915.

This essay explores some of the metapsychological foundations about the gaze as well as the importance of the function of the eye in the Freudian theoretical production, aware that the eye and the gaze are not the same. The present approach starts from the difference between vision and gaze so that, conceptually, it can be traced the function of the eye and the impact of gaze in the first Freudian writings, especially at the level of the drive. It specifically refers to the theory of the drives and its later theoretical repercussion, to then immediately approach his first psychoanalytic writings, starting with Three Essays on the Theory of Sexuality. The substantial section of this essay brings the reader to the merely metapsychological issue of the “drive to see” (Schautrieb) exposed in texts such as Three Essays on the Theory of Sexuality from1905 and “Instincts and their Vicissitudes” from 1915.

Cet essai explore quelques-unes des bases méta-psychologiques sur le thème du regard et celui de l’importance de la fonction de l'œil dans la production théorique freudienne, tout en sachant que l'œil et le regard ne sont pas la même chose. Cette analyse est abordée à partir de la différence entre vision et regard, pour ensuite rechercher, de manière conceptuelle, la fonction de l'œil et l’impact du regard dans la constitution de la subjectivité, surtout au niveau de la pulsion. Ce travail vise de façon particulière la théorie des pulsions et sa répercussion théorique postérieure et, par la suite, aborde les premiers écrits psychanalytiques à ce sujet, en commençant par Trois essais sur la théorie sexuelle. La partie essentielle de cet essai développe le problème nettement méta-psychologique de la “pulsion de voir” (Schautrieb) exposé dans des textes tels que Trois essais sur la théorie sexuelle de 1905 et “Pulsions et destins des pulsions” de 1915.

Expression of EGFR and hER-2 in colorectal carcinoma and their clinical significance / 临床与实验病理学杂志

Purpose To exp1ore the expression and c1inica1 significance of epiderma1 growth factor receptor( EGFR)and human epi-derma1 receptor-2(HER-2)in co1orecta1 carcinoma. Methods Immunohistochemistry(IHC)PV-9000 was used to detect the expres-sion of EGFR and HER-2 in 78 cases of co1orecta1 carcinoma. Si1ver in situ hybridization( SISH)was used to detect HER-2 amp1ifica-tion in co1orecta1 carcinoma. Results The positive rates of EGFR in 78 co1orecta1 carcinomas were 69. 23%( 54/78 ). The differ-ences of the expression of EGFR between different depth of invasion group and 1ymph node metastasis group were statistica11y signifi-cant. The differences of the expression of EGFR between different aging group,gender group,tumor size,different histo1ogica1 grading group and Dukes stage were insignificant. The positive rates of HER-2 in 78 cases of co1orecta1 carcinoma were 25. 64%(20/78). The differences of the expression of HER-2 between different depth of invasion group and 1ymph node metastasis group were statistica11y sig-nificant. The differences of the expression of HER-2 between different aging group,gender group,tumor size,histo1ogica1 grading group and Dukes stage were insignificant. The expression of EGFR and HER-2 was positive1y corre1ated. Among the 20 cases of HER-2 protein overexpression,10 cases showed HER-2 gene amp1ification,15 cases showed HER-2 protein overexpression(~)by IHC and 10 cases showed HER-2 gene amp1ification by SISH. The rate of HER-2 gene amp1ification was 66. 67%. 5 cases with 1ow HER-2 protein overexpression( +)and no case showed HER-2 gene amp1ification. Conclusions EGFR and HER-2 are high1y ex-pressed in co1orecta1 carcinoma. EGFR and HER-2 expression is connected to invasion and metastasis process of co1orecta1 carcinoma. The both may be synergy. The corre1ation between HER-2 protein overexpression(~)and HER-2 gene amp1ification is statisti-ca11y significant. Therefore,immunohistochemistry can be regarded as an initia1 screening method for HER-2 gene amp1ification,and then SISH testing shou1d be done as we11 to confirm the resu1t. It is usefu1 for mo1ecu1ar target therapy to detect HER-2 status in co1or-ecta1 carcinoma.

Inhibitory Effect of Chenodeoxycholic Acid-verticinone Ester on Tumor Growth of H22-bearing Mice / 医药导报

Objective To evaluate the antitumor effects of chenodeoxycholic acid-verticinone ester ( CDCA-Ver ) on tumor growth and immune system of H22-bearing mice. Methods Antitumor activity against a solid tumor mass was evaluated in Kunming mice. H22 cells were transferred into the abdomen cavity of Kunming mice. H22 cells were inoculated through subcutaneous injection at the right armpit of the mouse to establish a solid tumor model. At 24 h after H22 tumor cells inoculation, 40 tumor-bearing Kunming mice were randomly divided into 4 groups according to random number table ( n=10 each group):model control group, cyclophosphamide ( CTX) group, intraperitoneal CDCA-Ver injection group and intravenous CDCA-Ver injection group. In model control group, sterile 0. 9% sodium chloride solution (10 mL·kg-1 ) was intraperitoneally injected once daily. In CTX group and intraperitoneal CDCA-Ver injection group, CTX (20 mg·kg-1 ) and CDCA-Ver (20 mg·kg-1 ) was intraperitoneally injected once daily, respectively. In intravenous CDCA-Ver injection group, CDCA-Ver ( 20 mg · kg-1 ) was injected through tail vein once daily. CDCA-Ver, CTX and NS were injected into the mice of the experimental groups once daily for 10 days, respectively. The dose volume was 0. 1 mL · ( 10 g )-1 body weight. The positive control drug was cyclophosphamide. Ten mice were treated with 20 mg · kg-1 CDCA-Ver through intravenous injection ( i. v. ) . Ten mice were treated with 20 mg·kg-1 CDCA-Ver through intraperitoneal injection. The thymus and spleen indices and the tumor inhibition rate were assessed, and histopathological examination with haematoxylin and eosin ( H&E) staining was carried out to evaluate the antitumor effects of CDCA-Ver. Results CDCA-Ver ( ivor ip) suppressed the growth of solid tumor in H22-bearing mice. The inhibition rate was 48. 3% at the dose of 20 mg·kg-1 CDCA-Ver (ip). There was no significant difference between CDCA-Ver (ip) and CTX treated group (P<0. 05). Compared with the control, the weight of thymus and spleen of CDCA-Ver (ip) treated group was not obviously changed. But a significant weight loss of thymus and spleen in CTX group was observed, which was attributed to the immune suppression from CTX. The thymus and spleen indices in the CTX-treated mice were significantly lower than those of the control group (P<0. 01). We further conducted histopathological examination to confirm the results. The immune system was not suppressed by CDCA-Ver ( ip ) in tumor-bearing animals. The low toxicity of CDCA-Ver was an outstanding advantage for the development of newly anticancer drug. Conclusion CDCA-Ver treatment can significantly inhibit tumor growth in mice.

A comparative analysis of surface areas and ratio of the cervical spinal cord and the vertebral canal at the same levels via MRI on healthy individuals / Análisis comparativo de las áreas de superficie y proporción de la médula espinal cervical y el canal vertebral en los mismos niveles via resonancia magnética en individuos sanos

The determination of the normal values of the cross-sectional surface areas and ratios of the vertebral canal and the spinal cord on the healthy individuals is of great importance with regards to the fact that it provides convenience for the doctors to make correct pathological diagnosis because of the most suitable treatment. In this study, it has been aimed to determine the respective ratios between the vertebral canal and the spinal cord via measuring their cross-sectional surface areas at the C3­C6 vertebra levels. The study has been implemented on the Magnetic Resonance Images (MRI) of the cervical vertebral column from healthy individuals at the Department of Radiology, Meram Faculty of Medicine, Necmettin Erbakan University. The study has been applied to 67 (50 female-17 male) individuals whose ages varied between 14 and 59 and these individuals have been divided into two groups as below and over 40 years of age. During the cervical MRI examination, axial and sagittal images have been evaluated and measurements have been made on the non-pathological axial images. The vertebral canal and the spinal cord surface areas have been calculated in square millimeters at the C3­C6 levels. Also, we calculated the ratio between the spinal cord surface area and the vertebral canal surface area. The obtained data has been transferred on the computer and statistical analysis has been implemented via SPSS package program (for Windows, 15.0). The summary of the data has been stated as Mean±SD. It has also been compared with regard to sex and age groups (below and over 40 years of age) using the Student t-test. The relationship between parameters has been evaluated by means of Pearson correlation test. No significant discrepancy (P>0.05) has been determined between the male and the female subjects in terms of the vertebral canal and spinal cord surface area values. On the other hand, at the C4, C5 and C6 levels, a significant discrepancy (P<0.05) has been observed between male and female subjects in terms of the ratio of spinal cord surface to the vertebral canal surface, stating that the male have it larger than the female. A positive correlation (P<0.01) between the surface area and ratio data of both sexes has been determined. We believe that the results of this study will be useful for the fields of neurology, neurosurgery and physical therapy and rehabilitation, particularly in evaluating spinal atrophy.

La determinación de los valores normales de las áreas de superficie de la sección transversal y las proporciones del canal vertebral de la médula espinal en los individuos sanos es de gran importancia para los médicos, para realizar un diagnóstico patológico correcto y un tratamiento más adecuado. Este estudio se llevó a cabo para determinar las respectivas proporciones entre el canal vertebral y la médula espinal a través de la medición transversal de áreas de superficie, entre los niveles de las vértebras C3­C6. El estudio se realizó através de imágenes de resonancia magnética (IRM) de la columna vertebral cervical de individuos sanos en el Departamento de Radiología, de la Facultad de Medicina de Meram, Universidad de Necmettin Erbakan. En el estudio participaron 67 sujetos (50 mujeres, 17 hombres) entre 14 y 59 años de edad. Los sujetos fueron divididos en dos grupos, menores y mayores de 40 años de edad. Durante el examen de IRM cervical, se evaluaron imágenes axiales y sagitales, estas mediciones se realizaron en las imágenes axiales no patológicas. El canal vertebral y las áreas de superficie de la médula espinal fueron calculados en milímetros cuadrados entre los niveles C3­C6. Además, se calculó el cociente entre el área de superficie de la médula espinal y la superficie del canal vertebral. Los datos obtenidos de superficie del canal vertebral, fueron transferidos al equipo y el análisis estadístico se implementó a través del programa SPSS (para Windows, 15.0). El resumen de los datos fue declarado como Media±DE. También fueron comparados grupos entre ambos sexos y por edad (menores y mayores de 40 años de edad) através de la prueba t de Student. La relación entre los parámetros fue evaluada mediante la prueba de correlación de Pearson. No se observó discrepancia significativa (P>0,05) entre hombres y mujeres en términos del canal vertebral, y los valores de la columna vertebral de la zona de superficie dorsal. Por otro lado, a nivel C4, C5 y C6, se observó una discrepancia significativa (P<0,05) entre hombres y mujeres, en términos de la proporción de la superficie de la médula espinal y la superficie del canal vertebral, indicando que fue mayor en los hombres. Se determinó una correlación positiva (P<0,01) entre el área de superficie y los datos de proporción de ambos sexos. Creemos que los resultados de este estudio serán de utilidad en las áreas de la neurología, neurocirugía, como también en terapia física y rehabilitación, en particular en la evaluación de la atrofia espinal.

O índice de um enigma: o inconsciente e o fenômeno da premonição / The index of an enigma: the unconscious and the phenomenon of premonition

Em 1953, Devereux editou uma coletânea de textos de Freud sobre a psicanálise e o ocultismo. Apesar de pouco conhecidos, tais escritos foram fundamentais no debate com a filosofia francesa. Merleau-Ponty, por exemplo, debruçou-se sobre esta questão duas vezes: primeiro, relacionando a premonição com a percepção. Depois, a telepatia ao sentir. Sua conclusão nos leva a repensar o tema central da psicanálise: o inconsciente. Sua proposta é relacioná-lo à indivisão do sentir e à sua reversibilidade: vejo e sou visto...

In 1953, Devereux edited a collection of Freud's texts on psychoanalysis and the occultism. Despite these texts being little known, they were crucial in the debate with the French philosophy. Merleau-Ponty, for instance, addressed this issue twice. At first, relating the premonition with perception. At another time, he links the telepathy with the sense. His conclusion leads us to rethink the focus of psychoanalysis: the unconscious. His proposal is to link it with the unity of the sense and its reversibility: to see and being seen...

[Ca2+]i homeostasis and caspase-3 gene expression in verapamil-induced retinal pigment epithelium cells apoptosis in vitro / 国际眼科杂志(Guoji Yanke Zazhi)

(Ver)-induced human retinal pigment epithelium (RPE) cells apoptosis.hours to induce RPE cells apoptosis.The expression of apoptotic effector gene caspase-3 was assessed by reverse transcription polymerase chain reaction (RT-PCR).Single cell was measured using fluorescence indicator Fura-3/AM with MetaFluo4.5/coolsnapfx/IX70 intracellular Ca2+ fluorescence imaging system.RPE cells and it significantly increased after co-cultured with Ver.The fluorescence in resting RPE cells was strong and distributed throughout the cells.The nucleus appeared more fluorescent than the cytoplasm.Calcium fluorescence of RPE cells attenuated after co-cultured with Ver.[Ca2+]i homeostasis might play pivotal roles in Ver-induced RPE cells apoptosis.

Percutaneous pedicle screw fixation for traumatic thoracolumbar fracture without neurologic deficits / 中华创伤杂志

Objective To evaluate the feasibility and safety of percutaneous posterior pedicle screw fixation in treatment of traumatic thoracolumbar fracture without neurologie deficits. Methods From January 2007 through December 2007, there were 15 patients with traumatic fracture of the thoracic or lumbar spine without neurologie deficits treated within 10 days after injury. There were 10 males and 5 females at age range of 31-65 years (average 45.6 years). The fracture was located at T11 in 1, T12 in 4,L1 in 7, L2 in 2 and L3 in 1. Preoperative anteroposterior and lateral radiographs of the fractured spine as well as CT and MRI were done to evaluate injury severity of the vertebral body, spinal canal and diseolig-amentary structures. According to Magerl classification criteria, there were 10 patients with type A3 frac-ture, 3 with type A2 fracture and 2 with type A1 fracture, which were treated with pereutaneous posterior pediele screw fixation. Operative time and intraoperative blood loss were recorded to observe clinical re-suits. Results The average operation time was 82 minutes (65-110 minutes), with a mean intraopera-five blood loss of 35 ml (20-50 ml ). There were no conversions to open surgery, new neurological deficits or other surgery-related complications. All patients were followed up for 3-11 months (average 7.6 months), which showed that Cobb angle was corrected from preoperative (15.7±6.3)° to postoperative (3.5±1.2)°. Postoperative CT showed sound reduction of posterior bone displacement in all patients compared to preoperative CT results. Conclusions Percutaneous posterior pedicle screw fixation is fea-sible and safe surgical procedure with fine short-term outcome in treating traumatic thoracolumbar fracture without neurologic deficits. This technique offers serveral potential advantages over open approaches inclu-ding less tissue trauma and blood loss as well as quicker recovery.

El prefijo Ver / The prefix Ver

Este trabajo intenta situar las distintas acepciones del prefijo alemán Ver, en especial aquellas en las cuales indica rechazo, ubicando de este modo un recorrido trazado por el saber de la Lengua. Es un desarrollo ampliado y enriquecido de un escrito anterior mio “Algunas formas de rechazo“ (Colofón (1992- España).

Analgesic effect of oxysophoridine and its mechanism / 中草药

Objective To investigate the analgesic effect of oxysophoridine(OSR)and the influence of verapamil(Ver)on the antinociception of OSR when two drugs were co-administrated in mice.Methods The number of writhing within 15 min after ip different doses of OSR was observed in painful mouse mo- dels caused by acetic acid.The hot plate method was used to assess nociceptive sensitivity of CaCl_2 and Ver before ip OSR.Nitric oxide(NO)in serum was measured by spectrophotometry.Results The number of writhing was decreased and the latency of licking the hind paws was prolonged in a dose-dependent manner after ip OSR.The antinociception of OSR could be antagonized by CaCl_2 and enhanced by Ver.No inter- ference was detected in serum volume of NO.Conclusion These results suggest that OSR can antagonize the acute pain caused by acetic acid and hot plate in a dose-dependent manner in mice.Calcium channel blocker could enhance the effect of OSR.

Effects of coumarin from LEG on contractivity in isolated rabbit ileum / 中草药

Object To observe the effects of coumarin (CM) and Verapamil (Ver) on contractivity and its relationship with Ca 2+ in isolated ileal smooth muscle of the rabbits. Methods The effects of CM and Ver were observed in three doses by routine experimental methods in isolated rabbit ileal. Results CM and Ver inhibited the contraction of isolated ileal smooth muscle induced by acetylcholine and CaCl 2. The responses were a concentration-dependent and non-competitive manner. CM and Ver were effective against the initial and sustained peak induced by acetylcholine. Conclusion CM has a calcium-antagonistic effect which is similar to that of Ver.

The influence of hydrocholoride berbamine to the indothelium derived blood vessel relaxation induced by Acetylcholine / 中国药理学通报

In the Ca - free solution .the relaxation induced by acctylcholine ( Ach ) inthe rabbit aortic strips is inhibited and the inhibition is removed when the concentration of the Ca2+ is restored. In the groupe of ME ( norepinephrine ) 0.4 ?mol ? L-1 hydro-choloride berbamine (HBA ) 1, 10?mol ? L-1 and Verapamie (Ver) 0. 1, 1?mol ? L-1 did not inhibit the relaxation induced by Ach,and HBA has tendency of promoting the relaxation. While HBA 100?mol ? L-1 and Ver 10?mol ? L-1 inhibit the relaxation obviously. In the group of KCl,the three concentration of HBA and Ver all have the tendency of promoting the relaxation. The result suggest: thatthe effection of HBA to the relaxation of in-dothelium dependence is complicated, the higher concentration inhibit the relaxation and the lower promote it. It prove that the effection of HBA to the transportation of indothelium's Ca2+ or to the release of the EDRF is complicated