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Purpose: The proportion of axial length (AL) occupied by vitreous chamber depth (VCD), or VCD:AL, consistently correlates to ocular biometry in the general population. Relation of VCD:AL to ocular biometry in high myopia is not known. The purpose of this study is to evaluate the relation of VCD and VCD:AL to ocular biometry of highly myopic eyes. Methods: This was a cross?sectional retrospective study of records of 214 myopic eyes (<?1 D SE, aged 20–40 years) attending the refractive surgery services. High axial myopia was defined as AL >26.5 mm. Eyes with posterior staphyloma and myopic maculopathy were excluded. Records were assessed for measurements of AL, central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), white to white diameter (WTW), and vitreous chamber depth (VCD). Groups were formed based on increasing AL, while the sum of CCT, ACD, and LT was recorded as anterior segment depth (AS). The main outcome measure was the correlation of VCD and VCD:AL to ocular biometry. A comparison was also performed based on of degree of axial myopia. Results: Mean age of the patients was 27.0 ± 5.2 years. VCD showed a very strong correlation with AL (R = 0.98, P < 0.001) but did not correlate to any anterior parameter. VCD:AL showed moderate negative relation with AS (R = ?0.43, P < 0.001) and ACD (R = ?0.3, P < 0.001), while it had a weakly negative relation with LT (R = ?0.18, P = 0.006). VCD:AL showed strong negative relation (R > ~0.7) with AS in all individual groups of AL. Among anterior parameters, WTW showed the most consistent relation with ocular biometry. Conclusion: VCD:AL is a better correlate of ocular biometry in high myopia as compared to VCD. However, the correlation is weaker than that noted by previous studies done on the general population. Longitudinal studies of VCD:AL in the younger age group is recommended
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Purpose: The mechanism of ocular growth eludes us and research on vitreous chamber depth (VCD) is lacking. The purpose of this study was to evaluate the role of VCD and its ratio to axial length (AL) in relation to ocular biometry. Methods: This retrospective study of patients planned for cataract surgery was performed at a tertiary center. Data regarding AL, anterior chamber depth (ACD), lens thickness (LT), and central corneal thickness (CCT) of 640 eyes was noted. Anterior segment (AS) was measured as sum of CCT, ACD, and LT, while VCD was calculated as the difference between AL and AS. Correlation of VCD and VCD: AL with ocular biometry was the primary outcome measure. Three groups were formed on the basis of AL and Pearson correlation coefficient (R) was applied. Results: Mean VCD was 15.38+/?1.14 mm. Mean VCD: AL was 0.66+/?0.02. VCD had a very strong relation with AL (R = 0.9, P < 0.001) only, whereas VCD: AL had a good--strong relation with AL (R = 0.5, P < 0.001), AS (R = 0.7, P < 0.001), ACD (R = 0.3, P < 0.001), and LT (R = 0.5, P < 0.001). The relation of VCD: AL with AS was very strong across all groups (R ? -0.8, P < 0.001 in all groups). 85% of eyes in group with AL <22 mm had VCD: AL <0.67, conversely 85% of eyes with AL >24.5 mm had VCD: AL >0.67. Conclusion: We found VCD to have the strongest relation with AL. VCD: AL was more consistent and showed a strong relation to ocular biometry across all ALs. This suggests the possible utility of the ratio VCD: AL while evaluating ocular growth, refractive status, and myopia-related complications.
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@#AIM: To investigate the efficacy of intravitreal injection of conbercept on neovascular age-related macular degeneration(ARMD)and its effect on choroidal thickness. <p>METHODS: A total of 213 patients(345 eyes)with ophthalmologic diseases who were treated in our hospital from March 2014 to December 2017 were randomly divided into control group(<i>n</i>=106, 176 eyes)and observation group(<i>n</i>=107, 169 eyes). The control group was treated with intravitreal injection of triamcinolone acetonide and the observation group was treated with intravitreal injection of conbercept. The efficacy of the two groups and changes in choroidal thickness were compared and analyzed. <p>RESULTS: There was no significant difference in BCVA and CMT between the two groups before and after injection(<i>P</i>>0.05). However, BCVA and CMT in observation group and control group were significantly better than those before injection(<i>P</i><0.05), and there was significant difference between before and after injection. There was no significant difference in central retinal thickness and choroid thickness between the two groups at baseline(1, 3, 6mo)(<i>P</i>>0.05). However, the central retinal thickness and choroid thickness at 6mo were significantly lower than those at baseline and 1, 3mo(<i>P</i><0.05), which were statistically significant. After treatment, the total incidence of complications in the observation group and the control group were 5.7% and 7.7%, respectively, with no significant difference between the two groups(<i>P</i>>0.05). <p>CONCLUSION: Intravitreal injection of conbercept and triamcinolone acetonide has the same effect, which can not only improve and stabilize the visual acuity of patients, but also reduce the central retinal thickness and choroid thickness effectively. It has obvious curative effect and high safety, and has clinical application value.