Mefenamic acid-induced bilateral transient myopia, secondary angle closure glaucoma and choroidal detachment.

Drug-induced secondary angle closure is quite common and in the majority of cases simply stopping the medication leads to rapid reversal of the condition and resolution of glaucoma. We describe here a patient who presented with secondary angle closure glaucoma and myopia following mefenamic acid ingestion which was managed successfully by stopping the medication, symptomatic treatment and reassurance.

Comparison of the effects of vitamin E and mefenamic acid on the severity of primary dysmenorrhea

Primary dysmenorrhea has relatively high incidence which can influence the well being and activities of the sufferers. An experimental cross-over study was designed to compare the effectiveness of vitamin E and mefenamic acid on reducing the severity of dysmenorrheal symptoms. Eighty six female medical students, aged between 18-26 who were suffering from primary dysmenorrhea were recruited. After having written consent they were divided into two groups of 43 individuals who received 500 units of vitamin E [2 tablets of 400 and 100 units] and 750mg mefenamic acid [250mg IDS] per day respectively. Treatment with vitamin E was started 2 days before the beginning of menstruation and continued until the first day of bleeding [3 days in total] and mefenamic acid was administered only during the first 48 hours of menstruation [only two days] Severity of pain, duration of bleeding, duration of menstruation and other symptoms such as diarrhea, secondary nausea, vomiting, vertigo, headache, legache, epigastric pain, pelvic pain before and after the treatment were recorded. Severity of pain was monitored by visual analogue scale [VAS] method on a visual scale. Monitoring was carried out for 2 consecutive cycles in both groups. Crossover was carried out and observation was continued for another 2 cycles. The result of this study indictate that both vitamin E and mefenamic acid could reduce the severity of pain similarly nevertheless but vitamin E consumption, complications such as digestive disorders such aspyrosis, stomach-ache, nausea and fatigue were significantly less compared to mefenamic acid. It appears that mefenamic acid could be replaced by vitamin E in reducing complications of dysmenorrhea

effects of mefenamic Acid on the osmotic fragility of lacertilian erythrocytes

Osmotic fragility of red cells is increased by the use of mefenamic acid. The use of this analgesic induces hemolytic anemia. Study of osmotic f agility of RBCs of control and test was observed following administration of 7.1 mg, 10.5 mg and 14 mg/day mefenamic acid to each lizard. Increased osmotic fragility was observed with increase in the amount of dose on day 6 and day 12

Reticulated multifocal fixed drug eruption due to mefenamic acid - a new morphological pattern

Fixed drug eruption is a heterogeneous pattern of cutaneous reaction to certain drugs. Different morphological patterns of fixed drug eruption can occur. We describe a new morphology of fixed drug eruption showing a reticulated pattern as a result of ingestion of mefenamic acid and discuss the possible mechanism underlying such an appearance

Drugs causing fixed eruption in children. a study of 31 cases

This is the largest series of fixed drug eruption [FDE] in children ever reported from one centre. Out of thirty five clinically diagnosed cases of FDE, 31 patients were positive to oral provocation tests. Cotrimoxazole was the commonest cause of FDE. Other incriminated drugs were paracetamol, acetylsalicylic acid, phenylbutazone, ampicillin, amoxycillin, tetracycline, metamizole and mefenamic acid. Cross-sensitivity was seen between penicillin derivatives; Polysensitivity with various drugs was observed in 4 cases [12.8 percent]. Cross-sensitivity between ampicillin/amoxycillin and polysensitivity among different drugs are still unreported