Efectos del aceite de linaza sobre las concentraciones de resistina plasmática en mujeres con síndrome de ovarios poliquísticos / Effects of flaxseed oil on plasma resistin concentrations in women with polycystic ovary syndrome

RESUMEN OBJETIVO: Determinar el efecto del aceite de linaza sobre las concentraciones plasmáticas de resistina en mujeres con diagnóstico de síndrome de ovarios poliquísticos. METODOS: se realizó un estudio en 195 mujeres con diagnóstico de SOPQ que fueron tratadas con aceite de linaza por 12 semanas (n = 97; grupo A) y controles tratados con placebo (n = 98, grupo B). Se compararon las características generales, concentraciones hormonales, perfil lipídico y resistina. RESULTADOS: No se encontraron diferencias significativas entre ambos grupos con relación a las características generales (p = ns). Tampoco se encontraron diferencias significativas en las concentraciones de hormonales, glicemia y HOMA entre los grupos (p = ns). Las mujeres del grupo A y B no mostraron diferencias estadísticamente significativas en la ingesta total, ingesta de carbohidratos, proteínas y grasas totales entre los valores al inicio y al final del estudio (p = ns). Las mujeres del grupo A presentaron disminución concentraciones de colesterol total lipoproteínas de baja densidad y triglicéridos (p < 0,0001). Los valores promedio de resistina mostraron disminución significativa luego del tratamiento (p < 0,0001). No se encontraron diferencias estadísticamente significativas en los valores promedio de las diferentes variables en las mujeres del grupo B (p = ns). CONCLUSION: El aceite de linaza produjo disminución significativa en las concentraciones plasmáticas de resistina en mujeres con síndrome de ovarios poliquísticos luego de 12 semanas de consumo.

ABSTRACT OBJECTIVE: To determine effects of flaxseed oil over plasma concentrations of resistin in women with diagnosis of polycystic ovary syndrome. METHODS: A research was performed in 195 women with diagnosis of polycystic ovary syndrome who were treated with flaxseed oil for 12 weeks (n = 97; group A) and controls treated with placebo (n = 98, group B). Overall characteristics, hormonal, metabolic, lipid profile and resistin concentrations were compared. RESULTS: There were no significant differences between the two groups in relation to the general characteristics (p = ns). There were also no significant differences in hormonal, glycemia and HOMA concentrations between the groups (p = ns). The women in group A and B did not show statistically significant differences in total calories intake, carbohydrate, protein and total fat intake between initial and final values of study (p = ns). Women in group A had decreased concentrations of total cholesterol, low-density lipoprotein and triglycerides (p < 0.0001). Mean values of plasma resistin showed a significant reduction after treatment (p < 0.0001). No statistically significant differences were found in the mean values of the different variables in women of group B (p = ns). CONCLUSION: Flaxseed oil produced a significant decrease in plasma resistin concentrations in women with polycystic ovary syndrome after 12 weeks of consumption.

Co-administration of trientine and flaxseed oil on oxidative stress, serum lipids and heart structure in diabetic rats.

The administration of flaxseed oil or flaxseed oil plus trientine in diabetic rats reduced triglyceride, very low density lipoprotein, and total cholesterol. Furthermore, the combined treatment significantly increased superoxide dismutase activity and attenuated serum Cu2+. The results suggest that the administration of flaxseed oil plus trientine is useful in controlling serum lipid abnormalities, oxidative stress, restoring heart structure, and reducing serum Cu2+ in diabetic rats.

Flaxseed, olive and fish oil influence plasmatic lipids, lymphocyte migration and morphometry of the intestinal of Wistar rats / Óleo de linhaça, oliva e peixe influenciam os lipídios plasmáticos, migração de linfócitos e morfometria intestinal de ratos Wistar

PURPOSE: Evaluate the effect of flaxseed, olive and fish oil on the lipid profile, preservation of villosities and lymphocyte migration in the intestinal mucosa of Wistar rats. METHODS: Thirty Wistar male rats were divided into four groups, which received the AIN-93M diet, with changes only to their lipid source: flaxseed, olive, fish, and soy oil (control group). The serum was separated for the biochemical parameter analysis. A histological evaluation was performed in the ileal portion. RESULTS: The group which was fed fish oil presented lower values when compared to the other treatments for Total Cholesterol, High-density Lipoprotein Cholesterol and Triacylglycerol (p<0.05). The animals treated with fish and olive oils presented better intestinal villosities preservation. Less deposition of lymphocytes was observed in the flaxseed group (p<0.001). CONCLUSIONS: This study demonstrated that flaxseed, olive and fish oils present different responses than soy oil for the intestinal mucosa preservation and lymphocyte proliferation in Wistar rats.

OBJETIVO: Avaliar o efeito dos óleos de linhaça, oliva e peixe no perfil lipídico, preservação das vilosidades e migração de linfócitos na mucosa intestinal de ratos Wistar. MÉTODOS: Trinta ratos Wistar foram divididos em quarto grupos e receberam dieta AIN-93M, modificando para cada grupo apenas a fonte lipídica: óleo de linhaça, oliva, peixe e soja ( grupo controle). O soro foi separado para análise dos parâmetros bioquímicos. A análise histológica foi realizada na porção ileal. RESULTADOS: O grupo que recebeu óleo de peixe apresentou menores valores de colesterol total, lipoproteína de alta densidade e triacilglicerol (p<0.05). Os animais tratados com óleo de peixe e oliva apresentaram melhor preservação das vilosidades intestinais. Menor deposição de linfócitos foi observado no grupo tratado com óleo de linhaça (p<0.001). CONCLUSÃO: Este estudo demonstrou que os óleos de linhaça, oliva e peixe apresentam diferentes respostas em relação ao óleo de soja na preservação da mucosa intestinal e proliferação de linfócitos em ratos Wistar.

Evaluation of anti-inflammatory activity of plant lipids containing alpha-linolenic acid.

Two groups of fatty acids are essential to the body, the omega6 (n6) series derived from linoleic acid (18:2, n-6) and the omega3 (n3) series derived from alpha-linolenic acid (18:3, n-3). Fatty acids provide energy, are an integral part of the cell membranes and are precursors of prostaglandins, thromboxanes and leukotrienes collectively known as eicosanoids. Eicosanoids participate in development and synthesis of immunological and inflammatory responses. The fixed oils (1, 2, 3 ml/kg) containing alpha-linolenic acid, obtained from the seeds of Linseed (Linum usitatissimum), Soyabean (Glycine max) and Holy basil (Ocimum sanctum) were screened for their antiinflammatory activity using carrageenan, leukotriene and arachidonic acid induced paw edema models in rats and the antiinflammatory effects were compared with the standard drug indomethacin. Significant inhibition of paw edema was produced by all the oils in the highest dose (3 ml/kg) in all the models. While O. sanctum oil produced the maximum percentage inhibition in leukotriene induced paw edema, L. usitatissimum oil produced maximum percentage inhibition in carrageenan and arachidonic acid induced paw edema models. The results show that oils with higher alpha-linolenic acid content (L. usitatissimum and O. sanctum) produced a greater inhibition of paw edema suggesting that modulation of the course of inflammatory disorders may be achieved by altering the eicosanoid precursor (i.e. poly unsaturated fatty acids: PUFA) availability through dietary manipulation.

Effect of non specific immuno-stimulant [isoprinosine] and linseed oil on some immunological aspects in rats

In this study, the effect of the immunomodulating agents, isoprinosine and linseed oil was studied in male Sprague- Dawley rats. The LD50 of Proteus mirabilis of both agents was 418 mul of 48 hours growth compared with 296 mul in the control group, accordingly the survival index was calculated and body temperature was recorded. The effect of both compounds on the total body weight, liver, spleen and thymus weights and on the L + S + Thy: T ratio in both the normal and bacterially-infected animals was studied as well as their effect on the total leucocytic neutrophilic, lymphocytic and monocytic counts was estimated. The level of serum TNF-alpha and IFN-gamma was measured in both normal and bacterially- stimulated animals. The effect of linseed oil and isoprinosine on cholesterol, triglycerides, HDL-c and LDL-c were evaluated