Estimation of prostaglandin E2 and 6-Keto-prostaglandin F1 in cases of chronic tonsillitis

This study was carried out on 50 patients suffering from chronic tonsillitis of different age groups. Prostagl and in E2 and 6-ketoprostagl and in F1 were estimated in the tissue of tonsils by radioimmunoassay methods. It was concluded that the young age groups [4 - 7 years] had higher levels of prostagl and in E2 and 6-ketoprostagl and in F1. The young age groups [4 - 7 years and 8 - 12 years] had higher levels of prostagl and in E2 more than 6-ketoprostagl and in F1, the older age group [13 - 18 years] had higher levels of 6-ketoprostagl and in F1 than prostagl and in E2. The levels of prostagl and in E2 were higher than the levels of 6-ketoprostagl and in F1 in the tissues of tonsils; while in plasma 6-ketoprostagl and in, F1 was higher than prostagl and in E2. Prostagl and in E2 was secreted from lymphocytes of tonsils

Níveis teciduais da prostaglandina 6-ceto-pgf 1a e integridade da mucosa gástrica em pacientes com doença de Chagas / Tissue levels of 6-ketoprostaglandin F1 alpha and integrity of gastric mucosa in patients with Chagas disease

Foram estudados 14 pacientes com a forma digestiva da doença de Chagas manifestada por megaesôfago e/ou megacolón com sorologia positiva para a doença de Chagas e 10 indivíduos näo chagásicos. Todos os pacientes foram submetidos à endoscopia digestiva alta para diagnósticos e colheita de biópsia de antro para estudo histopatológico e dosagem da prostaglandina 6-ceto PGF1 alfa. Houve maior freqüência de gastrite moderada e intensa no grupo chagásico do que no grupo controle. Os níveis de 6-ceto-PGF alfa no grupo chagásico variou de 36,5 a 245,6 ng/g (mediana: 80,75 ng/g) e näo foram estatisticametne diferentes (p>0,10) dos níveis encontrados no grupo controle, que variou de 13,1 a 269,6 ng/g (mediana: 116,2 ng/g). Estes resultados näo apoiam a idéia de que a desenervaçäo intramural do estômago na doença de Chagas esteja associada à reduçäo da síntese local de prostaglandinas