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An. acad. bras. ciênc ; 73(1): 33-7, Mar. 2001. ilus, tab
Artigo em Inglês | LILACS | ID: lil-281082

RESUMO

The essential oil from Piper solmsianum leaves and its major compound (sarisan) were tested to verify their influences upon mice behaviour. The essential oil was obtained by hydrodistillation in a modified Clevenger extractor and analysed by GC/ MS. This analysis revealed in the oil the presence of monoterpenes, sesquiterpenes and of arylpropanoids. The compound sarisan, a myristicin analogue, was isolated from the oil to perform the pharmacological tests. Emulsions of the oil and of sarisan (5.0 and 10.0 percent v/v) were used in the tests. Pentobarbital (30 mg/ kg s.c.) or diazepam (2.5 mg/ kg s.c.) were tested as standard drugs to verify depressant or anxiolytic effects, respectively. Both essential oil and sarisan showed to have exciting and depressant effects in the tested animals


Assuntos
Animais , Masculino , Feminino , Camundongos , Comportamento Animal/efeitos dos fármacos , Óleos Voláteis/farmacologia , Óleos de Plantas/farmacologia , Acatisia Induzida por Medicamentos/fisiopatologia , Antifúngicos/farmacologia , Depressão/induzido quimicamente , Diazepam/farmacologia , Dioxolanos/farmacologia , Hipnóticos e Sedativos/farmacologia , Pentobarbital/farmacologia , Extratos Vegetais/farmacologia , Folhas de Planta , Ratos Endogâmicos
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