Synthesis of some new 9-substituted acridines of possible Antimicrobial activity

A series of 9-substituted acridines has been synthesized utilizing 3-[9-acridinyl] propanoylhydrazine, 9-[4-aminophenyl] acridine [II] and 9-chloromethylacridine [III] as starting materials. The hydrazones Ic and Id as well as the Schiff bases IIa-IIc were produced via condensation of the acid hydrazide Ib or the amine II with different aldehydes. The acid hydrazide Ib was also reacted with some acid anhydride to afford the pyridazinone derivatives Ie and If. In addition, 9-chloromethylacridine [III] was reached with glycine, sulfanilamide or sulfadiazine to give the corresponding N-alkylated derivative IIIa-IIIc. The structure of the synthesized products was substantiated by spectroscopic data and elemental analyses. Some of the prepared compounds were found to possess antimicrobial activity

Synthesis and antitumor activity of some 9- [4-substituted sulfamoylphenylamino] acridine-4-hydroxyalkylcarboxamide derivatives: Part II1

A series of 9-[4-substituted sulfamoylphenyl-amino] acridine-4-hydyroxyalkyl carboxamide derivatives has been synthesized in order to study the SAR of this class of compounds. The prepared final compounds have been evaluated for antitumor activity in NIH, Bethesda, Maryland, USA. No significant activity has been observed