Comparison of Eye Protection Methods of Ointment Instillation under General Anesthesia

PURPOSE: To compare the efficacy of 3 different eye ointment instillations with eyelid taping and eyelid taping alone to prevent eye complications during surgery under general anesthesia. METHODS: A total of 296 eyes of 148 patients who underwent general anesthesia for at least 60 minutes were randomly assigned to 1 of the following 4 groups: group A, eyelid taping alone; group B, eyelid taping with solcoseryl ointment; group C, eyelid taping with carbomer ointment; group D, eyelid taping with lanolin ointment. Schirmer test, tear film break-up time (TF-BUT), conjunctival hyperemia scale (CHS), National Eye Institute corneal staining scale (NSS), and ocular surface disease index (OSDI) were prospectively evaluated before and after general anesthesia. RESULTS: TF-BUT was significantly increased in the group B compared with the preoperative value (p = 0.035). CHS was significantly decreased in all 3 ointment groups (p < 0.05) after general anesthesia and the degree was significantly higher in groups B and C (p < 0.001). No corneal abrasion developed after general anesthesia. However, corneal erosion developed in 20 eyes of previously healthy subjects; 8 eyes (12.5%) in group A, 0 eye (0%) in group B, 2 eyes (2.5%) in group C, and 10 eyes (13.9%) in group D. The occurrence rates of new lesions were significantly lower in groups B and C (p = 0.035). CONCLUSIONS: Both eyelid taping alone and eyelid taping with eye ointment are effective protection methods against corneal abrasion during operation under general anesthesia. Eye ointment instillation together with eyelid taping shows not only improvement of subjective symptoms but also improvement of objective ocular surface parameters proving to be an effective ocular protection during general anesthesia.

Comparison of Eye Protection Methods of Ointment Instillation under General Anesthesia

PURPOSE: To compare the efficacy of 3 different eye ointment instillations with eyelid taping and eyelid taping alone to prevent eye complications during surgery under general anesthesia. METHODS: A total of 296 eyes of 148 patients who underwent general anesthesia for at least 60 minutes were randomly assigned to 1 of the following 4 groups: group A, eyelid taping alone; group B, eyelid taping with solcoseryl ointment; group C, eyelid taping with carbomer ointment; group D, eyelid taping with lanolin ointment. Schirmer test, tear film break-up time (TF-BUT), conjunctival hyperemia scale (CHS), National Eye Institute corneal staining scale (NSS), and ocular surface disease index (OSDI) were prospectively evaluated before and after general anesthesia. RESULTS: TF-BUT was significantly increased in the group B compared with the preoperative value (p = 0.035). CHS was significantly decreased in all 3 ointment groups (p < 0.05) after general anesthesia and the degree was significantly higher in groups B and C (p < 0.001). No corneal abrasion developed after general anesthesia. However, corneal erosion developed in 20 eyes of previously healthy subjects; 8 eyes (12.5%) in group A, 0 eye (0%) in group B, 2 eyes (2.5%) in group C, and 10 eyes (13.9%) in group D. The occurrence rates of new lesions were significantly lower in groups B and C (p = 0.035). CONCLUSIONS: Both eyelid taping alone and eyelid taping with eye ointment are effective protection methods against corneal abrasion during operation under general anesthesia. Eye ointment instillation together with eyelid taping shows not only improvement of subjective symptoms but also improvement of objective ocular surface parameters proving to be an effective ocular protection during general anesthesia.

comparative study between two techniques of grafting in significant jaw defects

The aim of this study is to compare both clinically and radio graphically the effect of mixture of hydroxyl apatite and dried protein standardized dialysate [solcoseryl dental adhesive paste] and using solcoseryl alone in augmenting a significant jaw defects

A pilot study on the culture and differentiation of bone marrow stromal cells from SD rats / 生物医学工程学杂志

In order to observe the growth, expansion and differentiation of the cultured bone marrow stromal cells (BMSC), we isolated the BMSC from adult SD rats and cultivated them with LIF and bFGF. Then, we cultured and induced the stem cells by using retinoic acid and the culture medium confected in our lab by ourselves. We found that the BMSC could expand and generate clones when they were cultured in vitro. These cells subcultured grew rapidly and differentiated into neuron-like cells and astrocyte-like cells. The results showed that BMSC have the abilities to self renew and differentiate, thus demonstrating the culture method we used is suitable for the culture of BMSC in vitro. The bone marrow stromal cell is not difficult to obtain; it is capable of expanding and differentiating in culture. If the culture condition is appropriate, it can differentiate into neuron and astrocyte. So, it is a kind of perfect seed cells.

The Effect of Yunkyo on Open Wound Healing in Rats

Wound healing of the skin and soft tissue defect is accomplished by generation of granulation tissue, collagen synthesis, contraction and re-epithelization. In the full-thickness skin wound, contraction plays an important role and fundamental principles in the treatment of infected wounds include the elimination of infection, the evacuation of pus, and the debridement of all necrotic material. The natural healing process of infected wounds can be expedited by the application of agents which will effectively eliminate infection with facilitating the healing process. Yunkyo is one of the most commonly used oriental herb medicine which is known to be effective in wound healing. In order to evaluate the effects of Yunkyo over wound healing and inhibition of bacterial growth, the author counted the bacterial colony in vitro and made skin defect on the back of rats for the comparison of reduced wound size and changes of tissue bacterial colony count after treatmnet with Solcoseryl, TCDO (Tetra-chloro-deca-oxide) and povidone. The results were obtained as follows: Calculating colony count in vitro, Yunkyo treated group was the most effective(p<0.001). There were significant differences between Yunkyo treated and control group in wound healing(p<0.001): Yunkyo healed the wound more rapidly. Calculating tissue bacterial colony count in open infected wound, Yunkyo treated group was showed the lowest colony count. In microscopic findings, the author observed marked growth of the granulation tissue, infiltration of the inflammatory cells, development of capillaries and even arrangement of collagen in Yunkyo treated groups than in the control group. In electron microscopy, abundant protein synthesis and myofilament in the myofibroblast were observed, and the authors found active wound contraction and the growth of granulation tissue. In conclusion, the Yunkyo has remarkable antibiotic effect and promotes wound contraction and the growth of granulation tissue in the process of wound healing.

A randomized controlled trial of Solcoseryl and DuoDerm in chronic sickle-cell ulcers

A randomized controlled trial of Solcoseryl, DuoDerm and conventional conservative therapy with Eusol has been performed in 32 patients with homozygous sickle-cell (SS) disease. After 12 weeks' baseline observation, patients were randomized to one of three therapies and monitored for a further 12 weeks. Of 44 ulcerated legs, 20 received control treatment, 12 Solcoseryl and 12 DuoDerm. DuoDerm was generally unacceptable, and two-thirds of the patients defaulted from this treatment. Solcoseryl increased ulcer healing compared to the controls but the difference was not significant. Solcoseryl was well tolerated and may have a role in the treatment of chronic leg ulcers of sickle-cell disease.

Tratamiento de xantelasmas con quimioterapia tóxica / Treatment of xanthelasmas with toxic chemotherapy

Un total de 21 xantelasmas en los párpados (9 pacientes) fueron tratados con un preparado caústico de uso relativamente reciente. Dicha solución está constituida por una mezcla de ácidos orgánicos e inorgánicos, de manejo local e indicado para el tratamiento de diversas lesiones cutáneas. Los resultados obtenidos nos permiten apreciar buena tolerancia y efectos de este preparado en el tratamiento de los xantelasmas

new method of management of hypertensive pregnant patients and its effect on foeto maternal health

This study includes 160 patients suffering from mild or severe pregnancy induced hypertension. Half of patients have received the ordinary lines of treatment of P.I.H., while the other half received this treatment in additional to Solcoseryl injection. It has been found that the patients who have received Solcoseryl therapy had a significant increase in the foetal movements, increased foetal biparietal diameter, and gave births to babies who had a higher birth weight and a higher apgar score [1 min and 5 min] than those who did not receive it

protective effect of solcoseryl against indomethacin-induced gastric ulcer in the rat

The antiulcer effect of solcoseryl against indomethacin induced gastric ulceration is the rat as well as the effect of solcoseryl on the anti-inflammatory activity of indomethacin was studied. Intraperitoneal [I.P.] injection of indomethacin in a dose of 5 mg/kg once daily for 10 consecutive days produced severe gastric ulceration. Administration of solcoseryl in a dose of 3 ml/kg I.P. daily for 10 consecutive days concomitant with indomethacin resulted in a marked reduction in the ulcerogenic effect of indomethacin as indicated by reduction in the ulcer index. On the other hand, the anti-inflammatory activity of indomethacin [10 mg/kg, I.P.] in carrageenin induced rat hind paw edema model was not affected by concomitant injection of solcoseryl [3 ml/kg, I.P.]. In case of carrageenin induced rat granuloma pouch, a combination of indomethacin [5 mg/kg, I.P.] and solcoseryl [3 ml/kg, I.P.] given daily to the rats for 5 days did not alter the anti-inflammatory activity of indomethacin when compared with the results obtained in case of administration of indomethacin [5 mg/kg I.P.] alone for the same period

Pervention of surgically induced peritoneal adhesions in rabbits by solcoseryl

Thirty one pregnant female rabbits were used in the present study. For induction of adhesions, all animals received a standardized injury to their uterine horns a preximal part of fallopian tubes. The animals were then divided into five equal groups; the 1st group was kept as a control group; animals in the 2nd group were treated by I.M. hydrocortisone; animals in the third group were treated with I.M. solcoseryl; animals in the forth group were treated locally by solcoseryl jelly which was introduced intraperitoneally to cover all areas of injury prior to abdominal closure; animals in the last group were treated with solcoseryl locally together with I.M. injection. Two weeks later, laporatomy was done to each animal and adhesions were scored. It was found that both hydrocortisone and solcoseryle significantly reduced the adhesion formation as compared with the control group. The inhibitory action of hydrocortisone did not differ significantally from the results obtained by solcoseryl when used either locally or by I.M. injection. However, the difference was significant when solcoseryly was given I.M. concomitantly with local application