RESUMO
OBJECTIVE: Evaluate and compare the efficacy, safety, and tolerability of coal tar (10% LCD, liquor carbonis detergens), with betamethasone valerate in the therapy of large plaque-type psoriasis. MATERIAL AND METHOD: Patients with stable, mild to moderate plaque psoriasis at the Department of Medicine, Lerdsin General Hospital, Bangkok, Thailand were randomized for treatment with either coal tar (10% LCD) cream or betamethasone valerate cream (0.1%). All patients entered a 2 week wash-out period followed by the creams being applied twice daily until completion at 6 weeks. The patient severity of psoriasis was assessed using the modified Psoriasis Area and Severity Index (PASI) score at baseline and after 2, 4, and 6 weeks of treatment. RESULT: At the end of the trial, the mean reduction of the PASI score from baseline was 38.39% with the coal tar group and 69.36% with the betamethasone valerate group. The mean percentage of the PASI score reduction was statistically significant in both groups but the betamethasone valerate group was significantly superior to the coal tar group. Both drugs' adverse effects were limited to mild irritation localized to the skin without systemic side effects. The Betamethasone valerate cream was safe, effective, and well-tolerated while the coal tar cream was described as messy, malodorous, and with a tendency to staining clothes. CONCLUSION: The investigator's overall assessment of the treatment response at completion of the trial demonstrated that the betamethasone valerate group achieved significantly greater clearance and marked improvement compared with the coal tar group.
Assuntos
Adulto , Idoso , Anti-Inflamatórios/efeitos adversos , Valerato de Betametasona/efeitos adversos , Doença Crônica/tratamento farmacológico , Alcatrão/efeitos adversos , Progressão da Doença , Feminino , Indicadores Básicos de Saúde , Humanos , Ceratolíticos/efeitos adversos , Masculino , Pessoa de Meia-Idade , Psoríase/tratamento farmacológico , Tailândia , Resultado do TratamentoRESUMO
En las últimas dos décadas una importante bibliografía demostró que uno de los factores de riesgo más importantes para el avance de la lesión periodontal es el hábito de fumar. El tabaco, con los componentes nocivos que contiene, sumados a la combustión del papel, el escaso poder de filtración del filtro y el calor generado en la boca, son los factores que contribuyen al avance de la gingivitis, al desarrollo de la G.U.N.A., el aumento de la pérdida de inserción en la periodontitis y sería un factor determinante en la periodontitis refractaria. Además, es sabido que en enfermos con lesiones periodontales y con el hábito de fumar, deberán hacerse controles más periódicos y debe incentivarse la higiene bucal
Assuntos
Humanos , Doenças Periodontais/etiologia , Fumar/efeitos adversos , Cálculos Dentários/etiologia , Alcatrão/efeitos adversos , Placa Dentária/etiologia , Gengivite Ulcerativa Necrosante/etiologia , Gengivite/etiologia , Temperatura Alta/efeitos adversos , Monóxido de Carbono/efeitos adversos , Nicotina/efeitos adversos , Higiene Bucal , Perda da Inserção Periodontal/etiologia , Doenças Periodontais/prevenção & controle , Periodontite/etiologia , Fatores de RiscoRESUMO
Las dermatosis ocupacionales constituyen un amplio grupo de enfermedades que se presentan con frecuencia en la práctica dermatológica. Este artículo expone las patologías relacionadas con los diferentes ámbitos de la actividad laboral, sus aspectos clínicos más relevantes y los mecanismos etiopatogénicos involucrados