RESUMO
Visnagin (4-methoxy-7-methyl-5H-furo[3,2-g][1]-benzopyran-5-one), which is an active principle extracted from the fruits of Ammi visnaga, has been used as a treatment for low blood-pressure and blocked blood vessel contraction by inhibition of calcium influx into blood cells. However, the neuroprotective effect of visnagin was not clearly known until now. Thus, we investigated whether visnagin has a neuroprotective effect against kainic acid (KA)-induced neuronal cell death. In the cresyl violet staining, pre-treatment or post-treatment visnagin (100 mg/kg, p.o. or i.p.) showed a neuroprotective effect on KA (0.1 microgram) toxicity. KA-induced gliosis and proinflammatory marker (IL-1beta, TNF-alpha, IL-6, and COX-2) inductions were also suppressed by visnagin administration. These results suggest that visnagin has a neuroprotective effect in terms of suppressing KA-induced pathogenesis in the brain, and that these neuroprotective effects are associated with its anti-inflammatory effects.
Assuntos
Animais , Camundongos , Ammi , Benzoxazinas , Células Sanguíneas , Vasos Sanguíneos , Encéfalo , Cálcio , Morte Celular , Contratos , Citocinas , Frutas , Gliose , Glicosaminoglicanos , Hipocampo , Interleucina-6 , Ácido Caínico , Quelina , Neurônios , Fármacos Neuroprotetores , Fator de Necrose Tumoral alfa , ViolaRESUMO
In continuation of our earlier studies[1, 2, 3] the standardization of raw plant materials, the present study includes the morphological anatomical characteristics of the fruits along with the determination of physico-chemical constants, phytochemical screening. U V, IR, TLC, HPLC and GC-MS finger printing of different extractives of the powder of fruits of Ammi visnaga. The morpho-anatomical characteristics and results of the different chemical protocols would surely serve as a standard reference for identification of Ammi visnaga fruits