Use of rose bengal in the colorimetric determination of some anti histamines

A precise colorimetric method is described for the estimation of phenyltoloxamine citrate, diphenyltoloxamine hydrochloride and chlorpheniramine maleate. The method depends on ion-pair extraction of association formed between tertiary amines and Rose Bengal [RB]. The reddish-purple ion associated formations were readily extractable in dichloromethane and exhibited maximum at 555 nm. The method obeys Beer's law in the concentration range 2-20 mug ml-1 for diphenylhydramine hydrochloride or chlorpheniramine maleate and 4-40 mug ml-1 for phenyltoloxamine citrate. Optimization of the experimental conditions is described. The proposed method was applied to the analysis of these drugs in pharmaceutical preparations, and results were in good agreement with those obtained by the BP or USP method

Efeito de antiácido e bloqueadores H2 sobre a zona de alta pressao esofagogástrica do cäo / Effect of antiacido and H2 blockers on high pressure zone of esophagogastric funciton in dog

Em dez cäes machos, foi estudado o efeito da administraçäo oral de antiácido (hidróxido de alumínio) e bloqueadores H2 (cimetidina e ranitidina) sobre a zona de alta pressäo esofagogástrica (amplitude de pressäo e comprimento). Näo foram observadas modificaçöes na pressäo e comprimento na zona de alta pressäo esofagogástrica após a administraçäo das três drogas