Cytotoxic terpenoids from Satureja macrantha C. A. Mey

From the aerial parts of Satureja macrantha C. A. Mey, one monoterpene [1], two triterpenoids [2,3] and one sesquiterpene [4] were isolated. Their structures were determined to be thymol [1], oleanolic acid [2], ursolic acid [3] and caryophyllene oxide [4], by using 1H and 13C-NMR, FTIR and EIMS spectra. Brine shrimp cytotoxicity effects of the crude extracts and isolated compounds were examined. Among them compounds 1 [612 microM], 2 [17 microM] and 3 [29 microM] were effective against Artemia salina larva