RESUMO
OBJECTIVE: To evaluate the technical feasibility and clinical outcome of percutaneous aspiration embolectomy for embolic occlusion of the superior mesenteric artery (SMA). MATERIALS AND METHODS: Between January 2010 and December 2013, 9 patients with embolic occlusion of the SMA were treated by percutaneous aspiration embolectomy in 2 academic teaching hospitals. The aspiration embolectomy procedure was performed with the 6-Fr and 7-Fr guiding catheter. Thrombolysis was performed with urokinase using a multiple-sidehole infusion catheter. The clinical outcome was investigated retrospectively. RESULTS: Superior mesenteric artery occlusion was initially diagnosed by computed tomography (CT) in all patients, and all patients had no obvious evidence of bowel infarction on CT scan. Percutaneous aspiration embolectomy was primarily performed in 6 patients, and thrombolysis was initially performed in 3 patients. In 3 patients who received primary thrombolysis, percutaneous aspiration was undertaken because the emboli were resistant to urokinase. Complete angiographic success was achieved in 6 patients and partial angiographic success was accomplished in 3 patients. One patient underwent bowel resection. One patient died of whole bowel necrosis and sepsis, and 8 patients survived without complications. CONCLUSION: Percutaneous aspiration embolectomy is a useful tool in recanalization of embolic occlusion of the SMA in select patients.
Assuntos
Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Angiografia/métodos , Embolectomia/métodos , Embolia/complicações , Artéria Mesentérica Superior/diagnóstico por imagem , Oclusão Vascular Mesentérica/etiologia , Estudos Retrospectivos , Sucção/instrumentação , Terapia Trombolítica/métodos , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagem , Dispositivos de Acesso VascularRESUMO
OBJECTIVE: We wanted to evaluate the feasibility of catheter-directed thrombolysis with a continuous infusion of low-dose urokinase for treating non-acute (less than 14 days) deep venous thrombosis of the lower extremity. MATERIALS AND METHODS: The clinical data of 110 patients who were treated by catheter-directed thrombolysis with a continuous infusion of low-dose urokinase for lower extremity deep venous thrombosis was analysed. Adjunctive angioplasty or/and stenting was performed for the residual stenosis. Venous recanalization was graded by pre- and post-treatment venography. Follow-up was performed by clinical evaluation and Doppler ultrasound. RESULTS: A total of 112 limbs with deep venous thrombosis with a mean symptom duration of 22.7 days (range: 15-38 days) were treated with a urokinase infusion (mean: 3.5 million IU) for a mean of 196 hours. After thrombolysis, stent placement was performed in 25 iliac vein lesions and percutaneous angioplasty (PTA) alone was done in five iliac veins. Clinically significant recanalization was achieved in 81% (90 of 112) of the treated limbs; complete recanalization was achieved in 28% (31 of 112) and partial recanalization was achieved in 53% (59 of 112). Minor bleeding occurred in 14 (13%) patients, but none of the patients suffered from major bleeding or symptomatic pulmonary embolism. During follow-up (mean: 15.2 months, range: 3-24 months), the veins were patent in 74 (67%) limbs. Thirty seven limbs (32%) showed progression of the stenosis with luminal narrowing more than 50%, including three with rethrombosis, while one revealed an asymptomatic iliac vein occlusion; 25 limbs (22%) developed mild post-thrombotic syndrome, and none had severe post-thrombotic syndrome. Valvular reflux occurred in 24 (21%) limbs. CONCLUSION: Catheter-directed thrombolysis with a continuous infusion of low-dose urokinase combined with adjunctive iliac vein stenting is safe and effective for removal of the clot burden and for restoration of the venous flow in patients with non-acute lower extremity deep venous thrombosis.
Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Angioplastia com Balão , Cateterismo Periférico , Terapia Combinada , Fibrinolíticos/administração & dosagem , Bombas de Infusão , Infusões Intravenosas , Perna (Membro)/irrigação sanguínea , Flebografia , Terapia Trombolítica/métodos , Ultrassonografia Doppler , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagem , Grau de Desobstrução Vascular , Trombose Venosa/tratamento farmacológicoRESUMO
Acute embolic occlusion of the common iliac artery is a rare medical emergency that is not only limbthreatening, but also potentially life-threatening. Several treatment options exist for acute limb ischemia, although no treatment is clearly best. We report a case of acute embolic occlusion of the left common iliac artery in a patient with atrial fibrillation who was treated successfully using mechanical thrombectomy following intra-arterial thrombolysis.
Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Doença Aguda , Arteriopatias Oclusivas/diagnóstico por imagem , Terapia Combinada , Embolia/diagnóstico por imagem , Fibrinolíticos/administração & dosagem , Artéria Ilíaca/diagnóstico por imagem , Trombectomia , Terapia Trombolítica , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagemRESUMO
Portal and mesenteric venous thrombosis is an uncommon disease, but clinically important, because it accounts for 5% to 15% of acute mesenteric ischemia. The diagnosis is often delayed because the conditions are nonspecific abdominal symptoms. In addition, when this occurs in young individual without any known predisposing factor, the diagnosis may become even more difficult. The treatment of mesenteric venous thrombosis involves anticoagulation therapy alone or in combination with surgery. The addition of thrombolytic therapy to the treatment of portal and mesenteric venous thrombosis may enhance the clearance of thrombus and hasten the clinical improvements. We present a case of mesenteric venous thrombosis treated with catheter-directed infusion of urokinase via the superior mesenteric artery and systemic anticoagulation.
Assuntos
Adulto , Humanos , Masculino , Infusões Intra-Arteriais , Artéria Mesentérica Superior , Oclusão Vascular Mesentérica/tratamento farmacológico , Veias Mesentéricas , Veia Porta , Terapia Trombolítica , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagem , Trombose Venosa/tratamento farmacológicoRESUMO
We report on a case of ischemic dysfunction of the sinus node as a complication after percutaneous transluminal coronary angioplasty of the distal left circumflex artery. After local thrombolytic therapy in the sinus node artery, sinus node arterial flow was re-established and sinus node function normalized over the period of a week. Our experience suggests that immediate reperfusion of a totally occluded nodal artery can be re-established. Ischemic dysfunction of the sinus node, as a complication of angioplasty, is generally transient and requires a prolonged period for recovery. Therefore the decision to implant a permanent pacemaker should be delayed for at least one week after the ischemic insult.
Assuntos
Pessoa de Meia-Idade , Masculino , Humanos , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagem , Terapia Trombolítica/métodos , Nó Sinoatrial/fisiopatologia , Isquemia Miocárdica/complicações , Infusões Intravenosas , Seguimentos , Fibrinolíticos/administração & dosagem , Eletrocardiografia , Angiografia Coronária , Arritmias Cardíacas/diagnóstico , Angioplastia Coronária com Balão/efeitos adversosRESUMO
The purpose of this study was to propose that intrapleural urokinase (UK) instillation could reduce pleural thickening in the treatment of loculated tuberculous pleural effusion. Forty- three patients who were initially diagnosed as having loculated tuberculous pleural effusion were assigned at random to receive either the combined treatment of UK instillation including anti-tuberculosis agents (UK group, 21 patients) or strictly the unaccompanied anti-tuberculous agents (control group, 22 patients). The UK group received 100, 000 IU of UK dissolved in 150 ml of normal saline daily, introduced into the pleural cavity via a pig-tail catheter. The control group was treated with anti-tuberculous agents, excepting diagnostic thoracentesis. After the cessation of treatment, residual pleural thickening (RPT) was compared between the two groups. Clinical characteristics and pleural fluid biochemistry were also evaluated. The RPT (4.59 +/-5.93 mm) of the UK group was significantly lower than that (18.6 +/-26.37 mm) of the control group (p or = 10 mm (6.0 +/- 3.4 wks) was detected to be significantly longer than in those with RPT or = 10 mm, as compared to patients with RPT< 10 mm in the UK group. These results indicate that the treatment of loculated tuberculous pleural effusion with UK instillation via percutaneous transthoracic catheter can cause a successful reduction in pleural thickening.
Assuntos
Adulto , Feminino , Humanos , Masculino , Cateterismo , Derrame Pleural/tratamento farmacológico , Estudos Prospectivos , Tuberculose Pleural/tratamento farmacológico , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagemRESUMO
The purpose of this study was to evaluate the early outcome of endovascular management in patients with iliofemoral deep venous thrombosis (DVT) due to iliac vein compression syndrome (IVCS) and protein C and/or S deficiency. Between September 2000 and January 2003, catheter-directed thrombolysis was performed in 11 patients with a diagnosis of acute iliofemoral DVT: 7 with protein C and/or S deficiency and 4 without protein C and/or S deficiency. After thrombolysis, the diagnosis of IVCS was confirmed in 6 patients: 4 with protein C and/or S deficiency and 2 without protein C and/or S deficiency. Further intervention consisted of angioplasty and stent placement was performed. Four patients with IVCS and protein C and/or S deficiency were included in this study. The immediate technical and clinical success rates were 100% in all 4 patients. There were no complications or clinically detectable pulmonary emboli. This initial experience suggests that endovascular management of iliofemoral DVT due to IVCS in patients with protein C and/or S deficiency is safe and effective.
Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Veia Ilíaca , Ativadores de Plasminogênio/administração & dosagem , Deficiência de Proteína C/complicações , Deficiência de Proteína S/complicações , Terapia Trombolítica , Resultado do Tratamento , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagem , Trombose Venosa/complicaçõesRESUMO
This study was carried out to assess the effects of intracavitary injection of urokinase in the early liver abscess (ELA) of the rabbits. ELAs were induced on 25 in 47 New Zealand rabbits, which were divided into two groups, with 15 in group A, and 10 in group B. Urokinase was injected into the ELA of group A, and normal physiologic saline into those of group B. One and a half hours after the injections, the rabbits were sacrificed and evaluated by pathologists for the degree of fibrosis of the ELA wall, and fibrinolysis in the ELA itself. Statistical analyses were performed between the two groups. The following ELA sizes for each group were obtained: Group A, 4.3 X 2.9-10.1 X 7.2 mm (mean 7.1 X 4.1 mm); Group B, 4.6 X 2.7-15.0 X 9.7 mm (mean 8.5 X 4.57 mm). Eleven (73%) in group A showed grade II fibrosis of ELA wall, and 8 (80%) in group B showed grade III fibrosis of ELA wall (p=0.002). On pathological analysis, 5 (46%) in group A showed grade II fibrin, and 8 (80%) in group B showed grade III fibrin, of the ELA (p=0.09). In conclusion, injection of urokinase, into the ELAs, can reduce the degree of fibrosis of abscess walls.
Assuntos
Coelhos , Animais , Fibrinolíticos/administração & dosagem , Fibrose , Injeções , Abscesso Hepático/tratamento farmacológico , Supuração , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagemAssuntos
Humanos , Empiema Pleural , Derrame Pleural , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagem , Ativador de Plasminogênio Tipo Uroquinase/uso terapêutico , Empiema , Empiema Pleural , Unidades de Terapia Intensiva , Pneumonia/complicações , Derrame Pleural , Estreptoquinase , Toracoscopia , Toracostomia , ToracotomiaRESUMO
This article resumes the modern management of acute myocardial infarction. It analyzes the complementary benefits of two different types of treatment: thrombolytic therapy and percutaneous transluminal angioplasty
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Angioplastia Coronária com Balão , Angiografia Coronária , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagem , Ativadores de Plasminogênio/administração & dosagem , Eletrocardiografia , Estreptoquinase/administração & dosagem , Fibrinolíticos/administração & dosagem , Infarto do Miocárdio/diagnóstico , Infarto do Miocárdio/terapia , Recidiva , Terapia Combinada , Terapia TrombolíticaAssuntos
Humanos , Fibrinolíticos/uso terapêutico , Infarto do Miocárdio/tratamento farmacológico , Terapia Trombolítica/mortalidade , Fibrinolíticos/administração & dosagem , Fibrinolíticos/efeitos adversos , Infarto do Miocárdio/mortalidade , Infarto do Miocárdio/terapia , Terapia Trombolítica , Terapia Trombolítica/efeitos adversos , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagem , Ativador de Plasminogênio Tipo Uroquinase/uso terapêuticoAssuntos
Adulto , Angioplastia Coronária com Balão/efeitos adversos , Terapia Combinada , Angiografia Coronária , Trombose Coronária/etiologia , Eletrocardiografia , Humanos , Injeções Intralesionais , Masculino , Infarto do Miocárdio/terapia , Ativadores de Plasminogênio/administração & dosagem , Stents/efeitos adversos , Terapia Trombolítica , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagemAssuntos
Humanos , Cateterismo Venoso Central/enfermagem , Neoplasias/terapia , Cuidados de Enfermagem , Cateterismo Venoso Central , Cateterismo Venoso Central/classificação , Cateterismo Venoso Central/instrumentação , Cateteres de Demora , Enfermagem Oncológica , Permeabilidade , Punções , Estreptoquinase/administração & dosagem , Terapia Trombolítica , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagemAssuntos
Angiografia Digital , Aorta Abdominal/diagnóstico por imagem , Doenças da Aorta/congênito , Aortografia , Evolução Fatal , Feminino , Humanos , Recém-Nascido , Infusões Intravenosas , Terapia Trombolítica , Trombose/congênito , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagemRESUMO
Intra-carotid urokinase (UK) infusion in 20 patients with acute internal carotid artery (ICA) territorial ischemic stroke achieved immediate recanalization in 45% and the clinical outcome in patients with recanalization was superior to that of patients without recanalization. The procedure was most effective in patients with smaller arterial occlusions: 7 of 10 patients with MCA branch occlusions (M2 to M4) achieved recanalization compared to only 2 of 10 with distal ICA or M1 occlusions, which should be an important issue for the critical evaluation of the efficacy of thrombolytic therapy (TT). Hemorrhagic transformation was observed in 9 patients on CT scan; petechial hemorrhage in 5 and intraparenchymal hematoma formation in 4. Among 4 patients with hematoma formation, clinical deterioration was seen in 3 cases and the angiography at the immediate end of the UK infusion showed recanalization in only one patient. The average dose of UK in patients with parenchymal hematoma formation was higher than that of patients without hemorrhagic transformation (123.3 x 10(4) units vs 101 x 10(4) units). The administration of a large dose of UK, probably more than 100 x 10(4) units, and the absence of immediate recanalization seemed to increase the risk of parenchymal hematoma formation. Despite the effort of investigators, the in-hospital time delay for the TT was significant which was mainly related to the time consuming preparation for angiography especially during night. A more effective system for the earlier intervention of acute ischemic stroke needs to be developed.
Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Angiografia , Isquemia Encefálica/tratamento farmacológico , Trombose das Artérias Carótidas/tratamento farmacológico , Pessoa de Meia-Idade , Terapia Trombolítica/métodos , Tomografia Computadorizada por Raios X , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagemRESUMO
La trombosis venosa profunda aguda puede presentar dos secuelas graves: la embolia pulmonar en la primera etapa y el síndrome postrombótico como complicación tardía. Es por lo tanto comprensible que la primera preocupación sea la implementación de una terapia activa como la trombolisis. Es necesario reabrir la oclusión en pocos días. Ello es posible sólo mediante la adición de factores exógenos tales como la Estreptoquinasa, la Uroquinasa y el TPA. Dosis altas de heparina se usan para reducir notoriamente la incidencia de embolia pulmonar. El tratamiento de mantenimiento se realiza con anticoagulantes orales como los cumarínicos y la Warfarina.
Assuntos
Extremidades/patologia , Farmacologia , Embolia Pulmonar/complicações , Tromboflebite/complicações , Tromboflebite/epidemiologia , Tromboflebite/terapia , Fibrinolíticos/uso terapêutico , Anticoagulantes/uso terapêutico , Fibrinolisina/administração & dosagem , Heparina/administração & dosagem , Heparina/efeitos adversos , Heparina/farmacologia , Heparina/uso terapêutico , Inibidores da Agregação Plaquetária/uso terapêutico , Estreptoquinase/administração & dosagem , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagem , Varfarina/uso terapêuticoRESUMO
Apresentamos o relato de dois casos de empiema pleural loculado, tratados atraves da instilacao de uroquinase no espaco pleural via dreno toracico, descrevendo sua tecnica e evolucao dos pacientes.