RESUMO
The deleterious effects of radiation have been recognized for a almost century and continue to be seen today, because of improved survival in patients treated for malignancy with radiotherapy with or without other treatments. The present study was designed to evaluate the effect of radiation on the weight and growth of long bones on young Albino rat litters. Anatomy Department, Basic Medical Science Institute, Jinnah Postgraduate Medical Center Karachi. July 2008 to December 2008. 20 litters [10 days age] of Albino rats were divided in two groups. Group A [control], and Group B, was given 5Gy gamma radiation to whole body for 2.02 mm. from 60-unit cobalt chamber. These groups were further divided into 2 sub-groups, each comprising of 5 litters, for 2 weeks and 4 weeks study. Their weight was observed weekly and their CRL, fore limb and hind limb was measured at the end of study. At the end of study, the animals were sacrificed under anesthesia; their long bones were removed and measured with Digital caliper. A significance decrease in the weight of irradiated animals was noted. There was a significant decrease in the measurement of CRL, Forelimb and Hind limb and there was a significant decrease in the length and width of long bones of radiated animals. Total body irradiation causes growth retardation, before epiphyseal plate closure. Irradiation of growing bone typically results in retardation of longitudinal growth
Assuntos
Animais de Laboratório , Radioterapia/efeitos adversos , Lâmina de Crescimento/efeitos da radiação , Osteoblastos/efeitos da radiação , Aumento de Peso/efeitos da radiação , Ratos , Osso e Ossos/efeitos da radiaçãoRESUMO
El objetivo de este estudio fue determinar la degradabilidad (DEMS) y digestibilidad aparente de la materia seca (DAMS) del forraje hidropónico de maíz (FHM) y su efecto sobre el consumo de materia seca (CMS) y ganancia diaria de peso (GDP) en ovinos tropicales. El estudio incluyó 3 experimentos (E1, E2 y E3); en E1 y E2 se evaluó la DEMS y DAMS, en tanto que en E3 se determinó el CMS y GDP. En el E1, se usaron bolsas de nylon en una vaca con rumen canulado consumiendo forraje ad libitum, siendo la DEMS a las 48 h de 42,2 por ciento. En el E2, se usaron cuatro machos ovinos (29,35 ± 2,37 kg. PV) durante 17 días (7 de acostumbramiento y 10 de recolección total de heces), siendo la DAMS de 55,9 ± 10,3 por ciento. En el E3, se usaron 10 ovinos machos en crecimiento (14,06 ± 1,87 kg. PV) asignados a 2 grupos (T0 y T1) de 5 animales cada uno. T0= dieta basal ad libitum + 250 g de afrechillo de trigo y T1= dieta basal ad libitum + 250 g de FHM. La GDP fue mayor en el T0 que en T1 (41,66 ± 12,68 vs. 12,16 ± 11,92 g/d; P<0,05). Asimismo, el CMS fue mayor para el T0 que para el T1 (218,35 vs. 108,95 ± 31,41 g/anim/d; P<0,05). Se concluyó que aunque la DEMS y DAMS resultaron aceptables, la respuesta animal en términos de CMS y GDP no es favorable para el FHM.
The objective of this study was to determine degradability (DEMS) and apparent digestibility of dry matter (DAMS) from hydroponic corn (FHM) as well as its effect on dry matter intake (DMI) and live weight gain (LWG) in tropical lambs. The study comprises 3 experiments (E1, E2 y E3); The E1 and E2 evaluated DEMS and DAMS, while in E3 the CMS and GDP were determined. For E1, nylon bags and a rumen cannulated cow consuming forrage ad libitum were used. In this experiment DEMS after 48 h was 42. 2%. For E2, four male ovines (29.35 ± 2.37 kg. LW of faeces). In this experiment, DAMS was 55.9 ± 10.3%. For E3, 10 growing male ovines (14.06 ± 1.87 kg. LW) allocated into 2 groups (T0 y T1) of 5 each were used. T0= basal diet ad libitum + 250 g of wheat middling. T1= basal diet ad libitum + 250 g de FHM. The LWG was greater in T0 than T1 (41.66 ± 12.68 vs. 12.16 ± 11.92 g/d; P<0.05). Likewise, DMI was greater for T0 compared to T1 (218.35 vs. 108.95 ± 31.41 g/anim/d; P<0.05). In conclusion, although DEMS and DAMS were acceptable, the animal response in terms of CMS y GDP was unfavourable to FHM.