RESUMO
The immune response elicited by the oral inoculation of an intermediate strain of infectious bursal disease virus was studied in chickens. A strong over expression of IL-6, IL-8, IFNα and IFNγ was observed in bursa at 3 days post inoculation together with an increase in splenic NO2 release. An influx of T-lymphocytes was also detected.
Assuntos
Animais , Infecções por Birnaviridae/veterinária , Galinhas , Vírus da Doença Infecciosa da Bursa/imunologia , Doenças das Aves Domésticas/imunologia , Administração Oral , Infecções por Birnaviridae/imunologia , Bolsa de Fabricius/patologia , Citocinas/análise , Citocinas/genética , Perfilação da Expressão Gênica , Óxido Nítrico/análise , Baço/patologia , Linfócitos T/imunologiaRESUMO
In the present study, 46 broiler chicken flocks [2-4 weeks of age in farms located in four governorates] were examined. They were affected with proventriculitis and stunting syndrome and were vaccinated with classical infectious bursal disease vaccines. The affected flocks generally showed stunting, reduced growth rate and uneven weight distribution. The virus was detected in the bursa at 72 hours PI by ELISA and electron microscope confirming the persistence of the variant IBDV in the chicks, despite the presence of IBDV classical antibodies. The present study reported, for the first time, the association of IBDV with stunting syndrome and proventriculitis in broilers in Egypt