Serum testosterone, sex hormone-binding globulin and total calcium levels predict the calcaneal speed of sound in men

OBJECTIVES: Variations in sex hormones and the calcium balance can influence bone health in men. The present study aimed to examine the relationship between the calcaneal speed of sound and biochemical determinants of bone mass, such as sex hormones, parathyroid hormones and serum calcium. METHODS: Data from 549 subjects from the Malaysian Aging Male Study, which included Malay and Chinese men aged 20 years and older residing in the Klang Valley, were used for analysis. The subjects' calcaneal speed of sound was measured, and their blood was collected for biochemical analysis. Two sets of multiple regression models were generated for the total/bioavailable testosterone and estradiol to avoid multicollinearity. RESULTS: The multiple regression results revealed that bioavailable testosterone and serum total calcium were significant predictors of the calcaneal speed of sound in the adjusted model. After adjustment for ethnicity and body mass index, only bioavailable testosterone remained significant; the total serum calcium was marginally insignificant. In a separate model, the total testosterone and sex hormone-binding globulin were significant predictors, whereas the total serum calcium was marginally insignificant. After adjustment for ethnicity and body mass index (BMI), the significance persisted for total testosterone and SHBG. After further adjustment for age, none of the serum biochemical determinants was a significant predictor of the calcaneal speed of sound. CONCLUSION: There is a significant age-dependent relationship between the calcaneal speed of sound and total testosterone, bioavailable testosterone and sex hormone-binding globulin in Chinese and Malay men in Malaysia. The relationship between total serum calcium and calcaneal speed of sound is ethnicity-dependent.

Ultrassonometria do calcâneo, densitometria óssea e morfometria vertebral em homens com idade acima de 60 anos / Quantitative ultrasound of the calcaneus, bone densitometry and vertebral morphometry in men over the age of 60 years

OBJETIVOS: Comparar a ultrassonometria do calcâneo com a densitometria óssea na avaliação de fraturas vertebrais morfométricas em homens acima de 60 anos. SUJEITOS E MÉTODOS: Foram analisados 96 homens com mais de 60 anos por meio de densitometria óssea da coluna, fêmur e rádio, radiografia lateral da coluna torácica e lombar e ultrassonometria do calcâneo. RESULTADOS: Cinquenta e um por cento dos homens apresentaram osteoporose e fraturas vertebrais. Foi observada correlação entre índice de stiffness e T-score da ultrassonometria e as densidades minerais ósseas (DMO) de todos os sítios. Quanto à presença de fraturas, identificou-se correlação com a DMO do rádio ultradistal e 33%. Por meio da curva ROC, observou-se acurácia da DMO do rádio UD na detecção de fraturas vertebrais. CONCLUSÕES: Nosso estudo mostrou correlação entre a ultrassonometria e a densitometria no diagnóstico de osteoporose em homens acima dos 60 anos. Também se identificou correlação entre fratura vertebral morfométrica e a DMO do rádio.

OBJECTIVES: To compare calcaneal ultrasonometry and bone densitometry in the evaluation of morphometric vertebral fractures in men over 60 years of age. SUBJECTS AND METHODS: We studied 96 men over 60 years of age by means of bone densitometry of the spine, femur and radius, lateral radiograph of the thoracic and lumbar spine, and calcaneal ultrasonometry. RESULTS: Fifty-one percent of men had osteoporosis and vertebral fractures. Correlation was found between ultrasonometry stiffness index, T-score and bone mineral density of the spine, femur and radius (p < 0.01). Regarding the presence of fractures, there was a correlation only with BMD of the ultradistal radius (UD) and radius 33%. ROC curve showed accuracy only of UD radius BMD in detecting vertebral fractures. CONCLUSIONS: Our study showed a correlation between osteoporosis diagnosis by ultrasonometry and densitometry in men over 60 years. It also showed a correlation between morphometric vertebral fracture and bone mineral density of the forearm.

The value of calcaneal bone mass measurement using a dual X-ray laser calscan device in risk screening for osteoporosis

OBJECTIVE: To evaluate how bone mineral density in the calcaneus measured by a dual energy X-ray laser (DXL) correlates with bone mineral density in the spine and hip in Turkish women over 40 years of age and to determine whether calcaneal dual energy X-ray laser variables are associated with clinical risk factors to the same extent as axial bone mineral density measurements obtained using dual energy x-ray absorbtiometry (DXA). MATERIALS AND METHODS: A total of 2,884 Turkish women, aged 40-90 years, living in Ankara were randomly selected. Calcaneal bone mineral density was evaluated using a dual energy X-ray laser Calscan device. Subjects exhibiting a calcaneal dual energy X-ray laser T- score <-2.5 received a referral for DXA of the spine and hip. Besides dual energy X-ray laser measurements, all subjects were questioned about their medical history and the most relevant risk factors for osteoporosis. RESULTS: Using a T-score threshold of -2.5, which is recommended by the World Health Organization (WHO), dual energy X-ray laser calcaneal measurements showed that 13 percent of the subjects had osteoporosis, while another 56 percent had osteopenia. The mean calcaneal dual energy X-ray laser T-score of postmenopausal subjects who were smokers with a positive history of fracture, hormone replacement therapy (HRT), covered dressing style, lower educational level, no regular exercise habits, and low tea consumption was significantly lower than that obtained for the other group (p<0.05). A significant correlation was observed between the calcaneal dual energy X-ray laser T-score and age (r=-0.465, p=0.001), body mass index (BMI) (r=0.223, p=0.001), number of live births (r=-0.229, p=0.001), breast feeding time (r=-0.064, p=0.001), and age at menarche (r=-0.050, p=0.008). The correlations between calcaneal DXL and DXA T-scores (r=0.340, p=0.001) and calcaneal DXL and DXA Z-scores (r=0.360, p=0.001) at the spine, and calcaneal DXL and DXA T- ...

Avaliaçäo isocinética pré e pós-operatória nas coalizöes tarsais / Pre and postoperative isokinetic evaluation in tarsal coalitions

O objetivo deste trabalho é o de demonstrar os resultados da avaliaçäo funcional na resseçäo operatória das colizöes tarsais talocalcaneanas e calcaneonaviculares. O ângulo máximo de movimento e o torque muscular máximo isocinético para a inversäo e eversäo do pé säo determinados em 12 pacientes (17 pés) portadores de coalizäo tarsal talocalcaneana (8) e calcaneonavicular (4). Säo avaliados oito pacientes do sexo feminino e quatro do sexo masculino com idades entre 10 e 16 anos (média = 13,2 anos). Todas as barras talocalcaneanas haviam sido tratadas com a ressecçäo da barra e interposiçäo de enxerto autógeno livre de gordura. As barras calcaneonaviculares foram tratadas através da excisäo da barra seguida da interposiçäo do tendäo do músculo extensor curto dos dedos. Os testes isocinéticos foram realizados em dinamômetro isocinético marca Cybex, modelo 350, no pré e pós-operatório. Foram avaliados os valores torque máximo por porcentagem de peso corpóreo, nas velocidades angulares de 30 a 120 graus/segundo. Os resultados demonstraram aumento significante da força muscular e dos valores do ângulo de movimento articular (p<0,05) após período pós-operatório mínimo de seis meses. Os autores concluem que a ressecçäo operatória é boa opçäo terapêutica das coalizöes tarsais talocalcaneanas e calcaneonaviculares, permitindo bons resultados funcionais.