Chronic mucocutaneous candidiasis: a case with exuberant cutaneous horns in nipples

Chronic mucocutaneous candidiasis is a rare disorder characterized by persistent and recurrent infections by Candida due to changes in cellular immunity and may be associated with autoimmune endocrine disorders. It is refractory to the usual antifungal treatments, which merely control it with imidazole derivatives. This reports the case of a 50-year-old female patient who referred vaginal discharge associated with vulvar ulcerated lesions and whitish plaques on oral and genital mucous membranes of onset in adolescence besides cutaneous horns in nipples. The clinical picture, family history, culture and anatomopathological studies were consistent with chronic infection by candida. Treatment with systemic antifungals obtained partial response of lesions characterizing a clinical picture of Chronic Mucocutaneous Candidiasis.

Determinação da atividade antifúngica dos óleos essenciais de curcuma longa l. (zingiberaceae) e de achillea millefolium (asteraceae) cultivadas no noroeste do Paraná / Determination of antifungal activity of essential oils of curcuma longa l. (zingiberaceae) and achillea millefolium (asteraceae) grown in the northwest paraná

No presente estudo, utilizou-se o óleo essencial das plantas Curcuma longa L. e Achillea millefolium, cultivadas no Horto Medicinal da Universidade Paranaense, localizado na cidade de Umuarama-PR região Noroeste do Paraná-Brasil. Para isso, os óleos foram obtidos pelo processo de extração por Clevenger modificado, e determinada a ação antimicrobiana frente a 20 cepas de microorganismos isolados de material clínico humano, sendo 16 leveduras da espécie Candida albicans isoladas da cavidade oral de pacientes portadores do Vírus da Imunodeficiência Adquirida (HIV), 3 leveduras isoladas de candidíase vulvovaginal (C. albicans, C. glabrata e C. tropicalis) e uma amostra de S. aureus isolado de lesões cutâneas. Por intermédio dos testes de microdiluição em caldo, os óleos de Achillea millefolium e de Curcuma longa demonstraram ação antimicrobiana considerada moderada (0,625 mg mL-1) em 63,2% e 68,4% das leveduras testadas, respectivamente. Ambos os óleos não apresentaram atividade frente ao S. aureus. Desta forma, sugere-se estudos adicionais para uso na incorporação dos óleos em formas farmacêuticas, com vistas ao uso no tratamento tópico de Candidíase mucocutânea.

It was used in this research the essential oil of the plants Curcuma longa and Achillea millefolium cultivated on the Medicinal garden of Universidade Paranense located on the city of Umuarama-PR. The oils were obtained by the process of steam distillation and was determined the microbial activity against 20 microorganisms isolated from clinical human material, being 16 yeasts of Candida albicans species isolated from the oral cavity from patients infected with Human Immunodeficiency Virus (HIV), 3 yeasts isolated from vulvovaginal candidiasis (C. albicans, C. glabrata and C. tropicalis) and one sample of S. aureus isolated from skin injuries. Through broth microdilution tests, the oils of Achillea millefolium and Curcuma longa showed moderated action (0,625 mg mL-1) on 63,2% e 68,4% of tested yeasts, respectively. Both Oils didn?t show activity against S. aureus. Therefore it is suggested further studies for use in the incorporation of oils in dosage forms with a view to use in the topical treatment of mucocutaneous candidiasis.