RESUMO
Rhodium (II) trifluoracetate (TFARh), rhodium (II) trifluoracetate adduct with sulfadiazine (TFARh.Sd) and rhodium (II) acetate adduct with sulfisoxazole (RhSx) were tested in mice for acute toxicity, antitumoral activity against Ehrlich ascites carcinoma and for viability of Ehrlich tumor cells in culture. At ip doses up to 60 µmg/kg (40-70 and 59 mg/kg, respectively), these coumpounds had no toxic effects up to 14 days. At ip doses of 10 µmol Kg-1 day-1 for 5 days, TFARh and TFARh.Sd significantly increased the survival rate of mice bearing Ehrlich ascites cells (probability of survival to the end of 34th day, controls = 0.23, TFARh = 0.85, TFARh.Sd = 0.74). No significant effect was observed for RhSx. In vitro, these rhodium complexes at 40 µM significantly increased the number of dead cells in cultured Ehrlich tumor cells
Assuntos
Camundongos , Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia , Carcinoma de Ehrlich/tratamento farmacológico , Técnicas In Vitro , Ródio/farmacologia , Acetatos/administração & dosagem , Carcinoma de Ehrlich/mortalidade , Camundongos Endogâmicos BALB C , Sulfadiazina/administração & dosagem , Sulfisoxazol/administração & dosagem , Fatores de Tempo , Ácido Trifluoracético/administração & dosagemRESUMO
OBJECTIVE--to verify the effects of Listeria monocytogenes (LM) inoculation in the survival of animals bearing Ehrlich's tumor. KIND OF STUDY--experimental. Animals-isogenic mice, Balb/c, female, 19-21 g. Tumor-Ascitic Ehrlich's tumor, dilution of 5 x 10(5) cells/0.1 ml. Bacteria-LM serotype 4a, solution with 7 x 10(3) bacteria (standard sub-lethal dose). Intervention-a) inoculation of LM in mice bearing Ehrlich tumor at the same time as ascitic cells transplantation. b) inoculation of LM seven days before and, again, seven and fourteen days after ascitic cells transplantation. c) to study the effect of using ampicillin 100 mg/kg, im, simultaneously with the inoculation of Ehrlich tumor and LM organisms and, again, 3, 5, 7, 14, 21 and 30 days after the ascitic cells transplantation. ANALYSIS--Chi-square test; p < 0.05 RESULTS AND CONCLUSION--LM increases significantly the survival of mice bearing Ehrlich tumor even when only one inoculum of viable LM was used, seven days before or seven days after the ascitic cells transplantation. The use of ampicillin after the inoculation of LM and tumor transplantation does not alter the survival of mice
Assuntos
Animais , Feminino , Carcinoma de Ehrlich/imunologia , Listeria monocytogenes/patogenicidade , Ampicilina/uso terapêutico , Carcinoma de Ehrlich/tratamento farmacológico , Carcinoma de Ehrlich/mortalidade , Distribuição de Qui-Quadrado , Avaliação Pré-Clínica de Medicamentos , Listeriose/tratamento farmacológico , Listeriose/imunologia , Listeriose/mortalidade , Camundongos , Camundongos Endogâmicos BALB CRESUMO
Rhodium II citrate was tested in mice for acute toxicity, antitumoral activity against Ehrlich ascites carcinoma and inhibition of DNA synthesis by Ehrlich tumor, malignant adrenocortical cells (Y-1) and normal adrenocortical cells (AR-1)_. At ip doses up to 260 mg/Kg, the compound had no toxic effects for up to 14 days. The same total dose given over 4 days significantly increased the survial rat of mice bearing Ehrlich ascites cells. Thymidine incorporation by Ehrlkich tumor, Y-1 cells in vitro was inhibited 50% by a.1 to 0.2 mM concentrations of the compound. We conclude that the increase survival of the tumor-bearing mice was due at least in part to the inhibition of DNA synthesis with a consequet reduction of cell division and tumor growth
Assuntos
Camundongos , Animais , Carcinoma de Ehrlich/patologia , Citratos/farmacologia , Ródio/farmacologia , Carcinoma de Ehrlich/mortalidade , Citratos/toxicidade , DNA/biossíntese , Ródio/toxicidadeRESUMO
Os autores estudaram o efeito da cimetidina na sobrevida de camundongos inoculados com o tumor de Ehrlich e concluíram que a droga aumenta a sobrevida desses animais, sugerindo ainda uma açäo imunomoduladora dessa substância
Assuntos
Animais , Masculino , Feminino , Camundongos , Carcinoma de Ehrlich/imunologia , Cimetidina/farmacologia , Carcinoma de Ehrlich/mortalidadeRESUMO
"Com a finalidade de contribuir ao estudo dos efeitos farmacológicos da "Espinheira Santa", realizamos os seguintes experimentos com seus respectivos resultados: Determinaçäo da DL em camundongos: näo foi menor que 80 mg/Kg. Açäo sobre o tumor de Erlich em camundongos: näo constatada. Dolorimetria em ratos: a droga possui efeito analgésico
Assuntos
Animais , Masculino , Feminino , Camundongos , Ratos , Plantas Medicinais , Carcinoma de Ehrlich , Extratos Vegetais , Carcinoma de Ehrlich/mortalidade , Analgesia , Dose Letal Mediana , Camundongos Endogâmicos BALB CRESUMO
Os autores estudaram a sobrevida de camundongos inoculados com o tumor de Ehrlich e concluíram que a famotidina e a ranitidina aumentaram a sobrevida destes aimais. Os autores também descreveram que a cimetidina, famotidina e a ranitidina näo alteram a hipersensibilidade tardia do BCG