1.
Indian J Physiol Pharmacol
;
1997 Apr; 41(2): 171-5
Artigo
em Inglês
| IMSEAR
| ID: sea-108776
RESUMO
Inclusion complex of plumbagin was prepared with betacyclodextrin employing neutralization method. The toxicity of the drug was reduced and the antitumor efficacy was enhanced on complexation with betacyclodextrin.
Assuntos
Absorção , Análise de Variância , Animais , Antineoplásicos Fitogênicos/administração & dosagem , Carcinógenos/metabolismo , Carcinoma de Ehrlich/tratamento farmacológico , Ciclodextrinas/metabolismo , Relação Dose-Resposta a Droga , Portadores de Fármacos , Sinergismo Farmacológico , Feminino , Dose Letal Mediana , Camundongos , Camundongos Endogâmicos BALB C , Naftoquinonas/administração & dosagem , Transplante de Neoplasias , beta-Ciclodextrinas
2.
Indian J Biochem Biophys
;
1991 Aug; 28(4): 247-51
Artigo
em Inglês
| IMSEAR
| ID: sea-28306
RESUMO
Cu(2+)-beta-cyclodextrin (1:1) complex has been found by UV, fluorescence and CD spectroscopy, polarimetry and gel electrophoresis to bind reversibly to calf thymus DNA. Using UV the binding constant was found to be 45280 +/- 7100 M-1. The binding of the complex Cu(2+)-BCD with DNA was stronger than that of free Cu2+. However the ternary complex formed thus was destroyed by EDTA.