RESUMO
Background & objectives: Conventional insecticides are generally used as larvicides to control Culex quinquefasciatus, vector of lymphatic filariasis. This study was undertaken to evaluate the larvicidal activity of some potential larvicidal plants leaf extracts against Cx. quinquefasciatus larvae. Methods: The toxic effects of petroleum ether leaf extracts of plants viz., Argemone mexicana (Mexican prickly poppy), Clausena dentata (Dentate), Cipadessa baccifera (Rana bili), Dodonaea angustifolia (Hop bush) and Melia dubia (Pride of India) were evaluated under laboratory conditions in individual and in combination against 3rd - 4th instar larvae of Cx. quinquefasciatus. Results: The results indicated that among the selected plants, A. mexicana showed maximum larvicidal activity with an LC50 value of 48.89 ppm. Its toxicity was enhanced when the extract was mixed (1:1) with that of C. dentata as the LC50 value became 28.60 ppm indicating synergistic action of A. mexicana. Interpretation & conclusions: Our results showed high larvicidal potential in A. mexicana leaf extract, and it also showed additive effect when mixed with C. dentata extract.
Assuntos
Animais , Clausena/química , Culex/efeitos dos fármacos , Culex/parasitologia , Filariose Linfática/parasitologia , Filariose Linfática/prevenção & controle , Filariose Linfática/transmissão , Insetos Vetores/efeitos dos fármacos , Insetos Vetores/parasitologia , Larva/efeitos dos fármacos , Larva/parasitologia , Extratos Vegetais/farmacologia , Folhas de Planta/químicaRESUMO
From the stem bark of Clausena heptaphylla, the limonoid clausenolide-1-methyl ether (1) was isolated. The structure of the compound was elucidated by extensive spectroscopic studies, including 2D NMR and MS measurements and by comparison with spectroscopic and physical data from the literature. This is the first report of occurrence of clausenolide-1-methyl ether (1) in Clausena heptaphylla.
El limonoíde clausenolido-1-metil eter (1) fue aislado de corteza de Clausena heptaphylla. La estructura del compuesto fue determinada por metodos espectroscópicos, incluyendo 2D RMN, espectrometría de masas (EM) y comparación de los datos espectroscópicos y constantes físicas con los publicados en la literatura. Este es el primer informe del aislamiento de clausenolido-1-metil eter (1) de Clausena heptaphylla.