Locacorten Vioform Ototoxicity Upon Guinea Pig Middle Ear Application

BACKGROUND AND OBJECTIVES: Locacorten Vioform (Novartis UK) is frequently prescribed for otomycosis. Its component, Clioquinol, also has anti-bacterial properties. Up to this point, its ototoxic potential has not been evaluated. Our objective aims to evaluate Locacorten Vioform’s potential ototoxicity when applied directly to the middle ear cavity. MATERIALS AND METHODS: We performed an experimental prospective animal study in our animal research center with 20 Hartley guinea pigs divided into 2 groups. The first group (experimental) was treated with Locacorten Vioform in one ear and with a physiologic saline solution in the other. The second group (positive control) was treated with concentrated gentamycin in one ear and physiologic saline in the other. Auditory brainstem response measurements were obtained before and after three sets of injections. Statistics were analyzed using a variance analysis with repeated measures. The histological state of cochlear outer hair cells was compared between the two groups using scanning electron microscopy. RESULTS: Average hearing loss in ears treated with Locacorten Vioform was 32.1 dB, compared with a 2.5 dB average loss in the saline-treated ears. Ears treated with gentamycin lost an average of 33.0 dB. There were clinically and statistically significant differences between the two ears of the guinea pigs in both groups (p < 0.001). Scanning electron microscopy revealed severe pericochlear and cochlear inflammation and ossification in the Locacorten Vioform-treated ears. Gentamycin caused significant destruction of outer hair cell architecture. CONCLUSIONS: Locacorten Vioform induces a hearing loss similar to that caused by gentamycin when applied directly to the middle ear of a guinea pig model. Electron microscopy indicates a pericochlear and cochlear inflammatory reaction with ossification.

Myringoplasty: a comparison of bismuth iodoform paraffin paste gauze pack and plane gauze [containing lococotien and veoform]

To assess difference between two methods of post-operative ear packing: bismuth iodoform paraffin paste [BIPP] versus plane gauze containing steroid and antibiotics [lococotien with veoform]. A retrospective study of patients who had undergone myringoplasty at our hospital from January 2005 to January 2007. Data, including age, size of perforation surgical approach, use of post-operative ear dressings, complications were collected from the patient notes and analysed. The overall success rate of the operation [with success being defined as an intact tympanic membrane at 12 months] was noted. Two hundred eighteen myringoplasties where data were completed are included in this study. Age ranged from 12 to 65 years [mean age 35 years] and the mean follow-up period was 12.61 months. The overall success rate was 83.5 percent. The success rate for BIPP and plane gauze [lococotien with veoform] was 80.9 and 86.4 percent respectively [p = 0.272]. In BIPP group [23.5%] developed granulation tissue formation in exteranal canal compare to 11.7 percent of [lococotien with veoform] group [p =0.023]. We found no significant difference in the success rate of myringoplasty between the BIPP and [lococotien with veoform] groups. However, there was a statistically significant difference between the two groups in term of granulation development. Packing with [lococotien with veoform] gauze has lower tendency to develop granulation tissue in the external canal following myringoplasty

Estudo comparativo in vitro entre a associaçäo de valerato de betametasona, sulfato de gentamicina, tolnaftato e clioquinol versus outros compostos nas cepas bacterianas e fúngicas mais freqüêntes nos meios comunitário e hospitalar / In vitrto comparative study between the association of betamethasone valerato, gentamicin sulfate, tolnaftate and clioquinol versus other medications on frequent bacterials and fungicals samples from communitary and hospitalar environment

A freqüência das infecçöes associadas fúngico-bacterianas cutâneas é um achado muito freqüênte na prática clínica diária. Devido a isso, o encontro de um produto eficiente para resolver essas dermatoses, economicamente viável e com uma comodidade de aplicaçäo é um desafio para os médicos no mundo inteiro. No corrente estudo, verificamos que a eficácia "in vitro" da associaçäo de valerato de betametasona, sulfato de gentamicina, tolnaftato e clioquinol em 20 cepas de Candida spp., Trichophytun spp., Streptococcus pyogenes, Staphylococcus aureus, Acinetobacter sp.,Escherichia coli, Pseudomonas aeruginosa e Pseudomonas aeruginosa resistente variou de 95 a 100 porcento, sendo maior e mais abrangente do que outros produtos antimicrobianos usados freqüêntemente em nosso mercado. Podemos considerar essa associaçäo uma alternativa eficaz no tratamento de infecçöes cutâneas com associaçäo de bactérias e fungos.(au)

Infecciones bacterianas cutáneas superficiales o impétigos: aspectos clínicos y terapéuticos / Superficial bacterial skin infections or impetigo: clinical and therapeutic aspects

Impétigo es una infección bacteriana, cutánea, superficial causada sobre todo por estafilococo dorado por estreptococo o por ambos. Es el padecimiento cutáneo infecto-contagioso más frecuente. Predomina en niños de estrato socioeconómicocultural bajo, en regiones húmedas y cálidas. Las lesiones son vesículas frágiles que se transforman en costras, preferentemente vecinas a los orificios naturales de la cara. El tratamiento consiste en antimicrobianos tópicos y/o sistémicos. La prevención consiste en el aseo y antisepsia de todo traumatismo que cause pérdida de la continuidad de la piel

Contact urticaria syndrome and anaphylactoid reaction from topical clioquinol and bacitracin (Banocin): a case report.

Topical application of a clioquinol and Bacitracin powder resulted in contact urticaria and an anaphylactoid reaction. Prick tests with clioquinol and bacitracin solution produced a wheal and flare response. This problem is unusual, but has been reported and previous reports are summarized.

Acetónido de fluocinolona mas clioquinol en infecciones micóticas o bacterianas superficiales de la piel / Fluocinolone acetonide and clioquinol micotic or bacterial surface infections of the skin

Se trataron 50 pacientes con procesos infecciosos bacterianos y micóticos superficiales de la piel con una combinación de acetónido de fluocinolona 0.025 y clioquinol 3.000 g en forma de crema para uso tópico. Se obtuvieron resultados buenos y excelentes en 100% de los casos según la opinión de las pacientes y en 82% según la opinión del investigador. Solamente en 18% de los casos se obtuvieron resultados moderados. Queda abierta la posibilidad de que conforme a la evolución del padecimiento y a criterio del médico tratante, el periodo de tratamiento se prolongue más allá de los 10 días de este estudio

Consideraçöes sobre o clioquinol / Clioquinol

Os autores apresentam uma revisäo sobre a neurotoxicidade do clioquinol e seus aspectos históricos em outros países. Concluem que näo há indicaçäo para o uso desta droga na atualidade. Sua popularidade e baixo custo näo säo fatores de relevância para a manutençäo de uma terapêutica sujeita a efeitos adversos graves. Recomendaçöes alternativas säo apresentadas para a terapêutica das enterocolites, com ênfase â orientaçäo sanitária