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1.
Biomédica (Bogotá) ; 33(1): 115-121, ene.-mar. 2013. ilus, graf
Artigo em Espanhol | LILACS | ID: lil-675139

RESUMO

Introducción. Ceratopteris pteridoides es un helecho semiacuático de la familia Parkeriacea, ampliamente utilizado en la medicina popular colombiana como diurético y colelitiásico, sobre el cual no existen reportes científicos que avalen su uso popular como diurético. Objetivo. Evaluar el efecto diurético agudo en dosis única y dosis repetidas a corto plazo, de los extractos etanólico y acuoso de C. pteridoides en un modelo in vivo . Materiales y métodos. El extracto etanólico total fue obtenido por maceración de la planta entera de C. pteridoides con etanol y el extracto acuoso fue obtenido por decocción a 60 °C por 15 minutos. Ambos extractos se sometieron a análisis fitoquímico preliminar y estudio histológico posterior a la administración de los extractos durante ocho días consecutivos (1.000 mg/kg). El efecto diurético se evaluó en ratas Wistar, tratadas con los extractos (500 mg/kg), en forma aguda y en dosis repetidas a corto plazo, cuantificando la eliminación de agua y la excreción renal de sodio y potasio por espectrofotometría de absorción atómica y, de cloruros, por titulación mercurimétrica. Resultados. En el modelo agudo, ambos extractos mostraron un significativo efecto diurético y de excreción renal de sodio y potasio en comparación con el control, mientras que con la administración en dosis repetidas a corto plazo mostraron efecto diurético sin eliminación de electrolitos. El estudio histopatológico no sugirió efectos tóxicos hepáticos o renales. Conclusión. Los resultados demuestran la actividad diurética de C. pteridoides y sustentan el uso popular dado a esta planta como diurético en la costa norte colombiana. Se requieren estudios posteriores que permitan aislar e identificar los compuestos responsables de la actividad y los mecanismos de acción involucrados.


Introduction. Ceratopteris pteridoides is a semiaquatic fern of the Parkeriacea family, widely used in the Colombian folk medicine as a diuretic and cholelithiasic, of which there are no scientific reports that validate its popular use. Objective. To evaluate the acute and short-term repeated-dose diuretic effect of the ethanolic and aqueous extracts of C. pteridoides in an in vivo model. Materials and methods. The total ethanolic extract was obtained by maceration of the whole plant of C. pteridoides with ethanol and the aqueous extract by decoction at 60°C for 15 minutes. Both extracts were evaluated in preliminary phytochemical analysis and histological studies after the administration of the extracts for 8 consecutive days (1000 mg/Kg). The diuretic effect was evaluated using Wistar rats treated with the extracts (500 mg/Kg), using an acute and a short-term repeated-dose model, and quantifying water elimination, sodium and potassium excretion by atomic absorption spectrophotometry, and chloride excretion by mercurimetric titration. Results. In the acute model both extracts showed significant diuretic, natriuretic, and kaliuretic effect compared to the control group. Whereas, a short-term repeated-dose administration showed a diuretic effect without elimination of electrolytes. The histopathologic study did not suggest a toxic effect in liver or kidney. Conclusion. The results represent evidence of the diuretic activity of C. pteridoides and give support the popular use given to this plant in the north coast of Colombia. Further studies are required to isolate and identify the compounds responsible for the activity and the mechanism of action involved.


Assuntos
Animais , Feminino , Ratos , Diurese/efeitos dos fármacos , Diuréticos/farmacologia , Extratos Vegetais/farmacologia , Pteridaceae/química , Colômbia , Cloretos/urina , Avaliação Pré-Clínica de Medicamentos , Diuréticos/administração & dosagem , Diuréticos/isolamento & purificação , Diuréticos/toxicidade , Etanol , Furosemida/farmacologia , Rim/efeitos dos fármacos , Rim/ultraestrutura , Fígado/efeitos dos fármacos , Fígado/ultraestrutura , Medicina Tradicional , Natriurese/efeitos dos fármacos , Fitoterapia , Extratos Vegetais/administração & dosagem , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/toxicidade , Potássio/urina , Ratos Wistar , Solventes , Água
2.
Bulletin of Alexandria Faculty of Medicine. 2007; 43 (2): 401-406
em Inglês | IMEMR | ID: emr-105859

RESUMO

The renal nerves are the communicating link between the central nervous system [CNS] and the kidney, contributing importantly to homeostatic regulation, renal blood flow [RBF], glomerular filtration rate [GFR], renal tubular solute and water transport and hormonal release. In patho-physiological conditions, abnormal regulation of efferent nerve activity constitutes significantly to associated abnormalities of renal function which in turn are of importance in the pathogenesis of many diseases such as hypertension. Denervation is a method commonly used to study the role of renal nerves in the control of kidney function, also it is mandatory in cases of kidney transplantation and when using ganglion blockers. To study the effect of renal denervation on kidney function in dog, using unilateral renal Denervation and split urine collection model. The left kidney was denervated through an abdominal approach. Urine and blood samples were collected for six clearance periods [10 minutes each]. The following parameters were done: Urine flow rate Uv [ml/min/m[2] surface area]. GFR [ml/min/m[2]] by inulin clearance method [C[1n]] Urinary excretion rate for Na[+], K[+], Cl[-l] [U[Na+] V, U[K+] V, U[cl-]. V for denervated [DNX] and innervated [INN] kidneys. Percentage fractional excretion of Na[+] [%FE[Na+] was also calculated for both kidneys. Marked diuresis, natriuresis, kaliuresis, chloresis and increased% FE Na[+] and GFR for the denervated [DNX] kidney were found as compared to the innervated [INN] control. Renal denervation results in marked diuresis and solute loss in the acute stage, therefore it is recommended to compensate for these losses especially in the early stages of renal Denervation whether surgical as in kidney transplantation or pharmacological as by delivering ganglion blockers or a-adrenoceptor inhibitors for patients with hypertension, otherwise grave water and electrolyte imbalances may occur


Assuntos
Masculino , Animais , Rim , Taxa de Filtração Glomerular/fisiologia , Sódio/urina , Potássio/urina , Cloretos/urina , Desequilíbrio Hidroeletrolítico , Cães
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