RESUMO
A study was made on Langerhans cells (LC) in the dermal lesions of leprosy after epicutaneous application of 2:4 dinitrochlorobenzene (DNCB) to the lesion. LC were quantitated with OKT6 monoclonal antibody and indirect immunofluorescence. A depletion or reduction in the numbers of CD1+ epidermal LC was observed at both 4 and 24 hours after the application of DNCB in the lesions of both tuberculoid and lepromatous leprosy, compared to untreated lesions.
Assuntos
Administração Cutânea , Anticorpos Monoclonais , Contagem de Células/efeitos dos fármacos , Dinitroclorobenzeno/uso terapêutico , Humanos , Células de Langerhans/efeitos dos fármacos , Hanseníase Virchowiana/tratamento farmacológico , Hanseníase Tuberculoide/tratamento farmacológicoRESUMO
The effects of an amino acid L-glutamine on aspirin-induced gastric lesions as well as on the mast cell population were studied in rats. L-glutamine had a pronounced inhibitory effect on gastric lesions produced by oral aspirin administration. Aspirin-induced increase in the mast cell population of the stomach was also prevented. Parenteral administration of aspirain did not produce any significant damage to the gastric mucosa.