Evaluation of disease modifying activity of Coriandrum sativum in experimental models.

Background & objectives: Coriandrum sativum (CS), has been widely used in traditional systems of medicine for treatment of rheumatoid arthritis. However, the mechanism of action for its antiarthritic effects is not clearly known. Therefore, the present study was carried out to evaluate the antiarthritic activity of CS in rats in two experimental models. Methods: The antiarthritic activity of CS seed hydroalcoholic extract (CSHE) was evaluated in adult Wistar rats by using two experimental models, viz. formaldehyde and Complete Freund's adjuvant (CFA) induced arthritis. The expression of pro-inflammatory cytokines (predominantly contributed by macrophages) was also evaluated. TNF-α level was estimated in serum by ELISA method. TNF-R1, IL-1 β and IL-6 expression in the synovium was analysed by immunohistochemistry. Results: CSHE produced a dose dependent inhibition of joint swelling as compared to control animals in both, formaldehyde and CFA induced arthritis. Although there was a dose dependent increase in serum TNF-α levels in the CSHE treated groups as compared to control, the synovial expression of macrophage derived pro-inflammatory cytokines/cytokine receptor was found to be lower in the CSHE treated groups as compared to control. Interpretation & conclusions: Our results demonstrate that the antiarthritic activity of CSHE may be attributed to the modulation of pro-inflammatory cytokines in the synovium. In further studies CSHE could be explored to be developed as a disease modifying agent in the treatment of RA.

Cytotoxicity and oxidative stress of arsenic and the possible ameliorative effect of Coriandrum Sativum L. in albino rats

This work has been carried out in order to investigate the possible ameliorative effect of Coriander in arsenic - induced toxicity in albino rats. 2,3 Dimercaptosuccinic acid [DMSA] was used as chelating agent. To achieve this purpose, 60 adult albino rats were used and randomly divided into equal 5 groups [12 rats each]. Group 1 served as negative control, group 2 received daily 100 ppm of sodium arsenite in drinking water, group 3 rats received daily oral dose of sod. arsenite and Coriander seeds extract [CSE] [1 g/kg body weight]., group 4 rats received sod. arsenite and oral dose of DMSA [0.05 g/ kg b.w] for 5 days lasted. Group 5 rats received sod. arsenite, Coriander seeds extract [CSE] and DMSA for 5 days lasted. The experiment lasted for 8 weeks and blood samples were withdrawn 4 and 8 weeks after induction of toxicity and different treatments. The antioxidant potential was carried out using the methanolic extract of Coriander seeds. Reducing power assay and Diphenyl picrylhydrazyl [DPPH] radical scavenging assay methods proved the antioxidant potency of CSE. In-vivo studies using the different biochemical techniques and antioxidant parameters proved that sodium arsenite caused a significant increase in all parameters concerned the liver toxicity while treatment of CSE or DMSA caused an ameliorative effect on this toxicity. Induction of hepatotoxicity by arsenite together with CSE and DMSA proved the synergistic effects of these chelating agents on arsenite toxicity

Total phenolic content and versatile biological activity of some selected widely consumed Egyptian vegetables'extract

Ethanolic extract as well as essential oils of parsley [Petroselinum crispum], Coriander [Coriander sativum] and dill [Anethum graveolens L.] were subjected for biological evaluation. Thus, these extracts and vegetables oils were evaluated for their inhibitory effects against different types of microorganisms using the agar diffusion technique. The ethanolic extracts as well as the essential oils were tested against two Gram-positive bacterial strains [Bacillus subtilis and Staphylococcus aureus], two Gram-negative bacterial strains [Pseudomonas aeruginosa and Escherichia coli], one yeast strain [Candida albicans] and three fungal strains [Aspergillus fumigatus, Penicillium italicum and Syncephalastrum racemosum]. Furthermore, the previous extracts and essential oils were evaluated for their antioxidant activity using 1, 1-diphenyl- 2-picrylhydrazyl [DPPH] scavenging techaque

Atividade antimicrobiana do óleo volátil de Coriandrum sativum L. em salame italiano / Antimicrobial activity of volatile oil of Coriandrum sativum L. in Italian salami

O óleo volátil de Coriandrum sativum L. foi usado como aditivo natural em salame Italiano, com objetivo de estudar sua influência sobre a flora microbiológica normalmente desenvolvida pelo produto. O óleo volátil foi utilizado em duas concentrações 0,01 e 0,005 por cento sobre o produto final, apresentando ambas as concentrações efeito significativo na inibição de Staphylococcus aureus e bactérias aeróbias mesófilas frente à amostra controle, aumentando a segurança do produto ao consumidor.