Topical nicotine application in hamster cheek pouch under the influence of nigellone injection

The aim of this study was to investigate the effect of topical nicotine application to hamster cheek pouch under the influence of Nigellone injections. This study included 60 hamsters divided into 4 groups. The results revealed moderate dysplastic changes in group I painted with nicotine only. In group II treated with Nigellone and nicotine simultaneously, moderate to mild dysplasia was observed. In group III injected with Nigellone and stopped then painted with nicotine showed mild dysplasia. While in group IV injected with Nigellone and stopped, then painted with nicotine and Nigellone at the same time revealed almost normal epithelium with few atypical cells. The right cheek pouches of group I were served as control