1.
Southeast Asian J Trop Med Public Health
;
1988 Sep; 19(3): 493-500
Artigo
em Inglês
| IMSEAR
| ID: sea-36179
RESUMO
Recent analysis of Japanese encephalitis (JE) virus genome RNA, especially its nucleotide sequence, revealed the localization of virion envelope glycoprotein (E) gene on the virus genome. Since the E protein is the major protective antigen related with the virus neutralization, attempts have been made to produce the second generation JE vaccine by expressing the E protein using recombinant DNA technologies. These studies will eventually lead to control JE by mass-vaccination in several Asian countries where JE is one of the major public health problems.