Biochemical and electroencephalographic changes in the brain of rats treated with fluphenazine decanoate

Treatment of rats with 0.5 mg/kg fluphenazine decanoate every 2 weeks for 4 doses caused significant increase in the level of whole brain gamma amino butyric acid [GABA], glutathione and glutamic acid decarboxylase [GAD] activity and no significant changes in L- glutamic acid. EEG records showed damping in amplitude without changes in frequency. The data of this study suggested that the effects of antipsychotic drugs on dopaminergic systems could be secondary to the effects on GABA neurons