RESUMO
The reaction of 0-vanillin 1 with phenylenediamine isomers 2-4 in dichloromethane formed three diaminobenzene derivatives: N,N'-bis [2-hydroxy-3-methoxybenzylidene]-1,2-diaminobenzene 5, N,N'-bis [2-hydroxy-3-methoxybenzylid-ene]-l,3-diaminobenzene 6 and N,N'-bis [2-hydroxy-3-methoxybenzylidene]-l,4-di-aminobenzene 7, respectively, All compounds were obtained as single crystals and the structures were determined by X-ray crystallography. All compounds were confirmed by FTIR, HRMS, ID and 2D NMR spectroscopy. The complete assignments of these compounds, using ID and 2D NMR including APT, DEPT-135, COSY, HMQC and HMBC in CDC1[3], will be discussed
Assuntos
Derivados de Benzeno/síntese química , Diaminas/química , Diaminas/síntese química , Análise EspectralRESUMO
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 µg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 µg/mL.