RESUMO
Two cardiac glycosides, namely digitoxin and digoxin when treated with goat blood, were found to alter the lipid constitution as measured by their phosphorus content, fatty acid composition and malonaldehyde content. There was significant increase in the poly-unsaturated fatty acids (PUFA) and malonaldehyde contents in blood treated with these drugs. Possible correlation between the lipophilicity of the drugs and their biological activity is discussed.
Assuntos
Animais , Cardiotônicos/farmacologia , Digitoxina/farmacologia , Digoxina/farmacologia , Ácidos Graxos não Esterificados/sangue , Ácidos Graxos Insaturados/sangue , Cabras , Lipídeos/sangue , Malondialdeído/sangue , Substâncias Reativas com Ácido Tiobarbitúrico/análiseRESUMO
Os autores mostram a relevância da intoxicaçäo digitálica dentre as emergências cardiológicas. Realçam a utilidade dos anticorpos monoclonais na intoxicaçäo suicida e o uso do sulfato de magnésio
Assuntos
Humanos , Masculino , Feminino , Anticorpos Monoclonais/uso terapêutico , Glicosídeos Digitálicos/efeitos adversos , Doenças Cardiovasculares/induzido quimicamente , Sulfato de Magnésio/uso terapêutico , Preparações Farmacêuticas/efeitos adversos , Arritmias Cardíacas/etiologia , Glicosídeos Digitálicos/farmacologia , Digitoxina/farmacologia , Digoxina/farmacologia , Doenças Cardiovasculares/tratamento farmacológico , Infarto do Miocárdio/complicações , Manifestações NeurológicasRESUMO
Nineteen male rabbits were included in the present study and classified into three groups to study the effect of repeated oral daily administration of digitoxin [10 mug/kg body wt.] or digoxin [50 mug/kg body wt.] for four weeks on some liver functions [SGPT, SGOT, total serum bilirubin, total serum proteins, serum alkaline phosphatase and prothrombin activity], ferrokinetic parameters [basal plasma iron, post absorption plasma iron tolerance curve, TIBC, UIBC and percent saturation of transferrin], hematological parameters [red cell count, hemoglobin concentration, hematocrit value and red cell indices] and histochemical parameters [iron contents and peroxidase enzyme activity in both the liver and kidney]. The results showed that digoxin produced significant decrease of basal plasma iron, post absorption curve and percentage of saturation of transferrin with significant increase of UIBC. Digoxin produced also mild reduction of iron contents and peroxidase enzyme activity in both the liver and kidney. Digitoxin produced insignificant changes in all the studied parameters. The findings of the present study may suggest that oral administration of digoxin interferes with some ferrokinetics, mainly the intestinal absorption of iron. The effect of digoxin on ferrokinetics seems to affect the cellular iron containing enzymes. The addition of iron therapy was recommended, whenever possible, to patients receiving digoxin for a long time